Drug-drug interaction between ticagrelor and fazamorexant: pharmacokinetic alterations in healthy subjects from a phase I, open-label, fixed-sequence study [0.03%]
替卡格雷与法扎莫克斯的药物相互作用：健康受试者I期、开放标签、固定序列研究中的药动学变化
Xingxing Huang,Yuzhu Chen,Lu Jin et al.
Xingxing Huang et al.
Purpose: Fazamorexant, a dual orexin receptor antagonist (DORA) targeting insomnia, demonstrated in vitro metabolism via CYP3A4. Thus, the effects of CYP3A4 inhibitors on the pharmacokinetics, safety, and tolerability of ...
Elucidating metabolic dysfunction induced by titanium dioxide in intestinal epithelial cells using an integrative approach of metabolomics and transcriptomics [0.03%]
整合代谢组学和转录组学方法阐明二氧化钛引起的肠上皮细胞代谢功能障碍
Xinchen Wang,Shilong Jiang,Zhengyu Gu
Xinchen Wang
Background: Titanium dioxide (TiO2) is widely present in a variety of food and personal care products, leading to frequent human exposure primarily via oral ingestion. Although the oral bioavailability of TiO2 nanoparticl...
Cardiac effects of prolonged recombinant human interleukin-11 treatment in severe thrombocytopenia: a retrospective cohort study [0.03%]
重组人白细胞介素-11长期治疗严重血小板减少症对心脏的影响：回顾性队列研究
Xian-Fa Li,Yue Sun,Wen-Rong Wang et al.
Xian-Fa Li et al.
Background: Recombinant human interleukin-11 (rhIL-11) is commonly used to treat thrombocytopenia induced by cancer chemotherapy. However, concerns about its potential cardiac side effects, especially with prolonged use, ...
In vitro toxicity of piperazine derivatives involves mitochondrial dysfunction and microtubule-related changes in neuronal cell models [0.03%]
哌嗪衍生物的体外毒性涉及神经细胞模型中的线粒体功能障碍和微管相关变化
Dina Rönnberg,Stig O P Jacobsson
Dina Rönnberg
Background: Piperazine derivatives such as BZP and TFMPP have been used as "party pill" substitutes for MDMA and are associated with neurological and cardiovascular toxicity. While their psychoactive effects are largely a...
Pycnogenol attenuates thioacetamide-induced neurobehavioral impairment and hepatotoxicity via multi-target molecular modulation [0.03%]
法国松树皮提取物通过多靶点分子调节缓解噻乙胺诱导的神经行为障碍和肝毒性
Selçuk Senyayla,Ahmet Hacimuftuoglu,Cemil Bayram et al.
Selçuk Senyayla et al.
Background: Hepatic encephalopathy (HE) is a neuropsychiatric syndrome associated with liver dysfunction and remains a major cause of mortality among patients with advanced liver disease. This study aimed to evaluate the ...
Short-term repeated-dose oral toxicity and mutagenicity studies on rice-derived glucosylceramides [0.03%]
短链稻米神经酰胺糖苷的急性口服毒性试验及致突变性试验
Hiroshi Shimoda,Norityuki Yamazaki,Terry Maniatis et al.
Hiroshi Shimoda et al.
Background: Food-derived glucosylceramides (GlcCer) have been used for functional foods; however, limited information is currently available on their safety. Therefore, we examined the toxicity of repeated oral dose and m...
Optimizing imatinib sampling strategies through a population approach: a crucial step to model-informed precision dosing validation for point-of-care therapeutic drug monitoring [0.03%]
通过群体药理学方法优化伊马替尼采样策略以实现精准给药指导床旁治疗药物监测的重要步骤
Yuan J Pétermann,Junrui Chen,Lavinia Alberi et al.
Yuan J Pétermann et al.
Background: Imatinib therapeutic drug monitoring (TDM) contributes at optimizing exposure, yet its implementation is limited by logistical constraints, including strict sampling time requirements. Model-Informed Precision...
Prioritization of molecular signatures between BDE-209-relevant targets and ulcerative colitis: a network toxicology and bioinformatics analysis [0.03%]
基于网络毒理学和生物信息学的BDE-209相关靶点与溃疡性结肠炎分子标志物优先级分析
Yue Zhang,Hai Zhang,Danli Hu et al.
Yue Zhang et al.
Background: Decabromodiphenyl ether (BDE-209) is a widely used flame retardant and persistent environmental contaminant. However, the overlap between predicted BDE-209-related targets and ulcerative colitis (UC)-associate...
Parabens exposure in systemic lupus erythematosus: insights from network toxicology and molecular docking [0.03%]
网络毒理学和分子对接在系统性红斑狼疮中暴露的对羟基苯甲酸酯研究
Hui Li,Qin Guo,Tiantian Zhang et al.
Hui Li et al.
Background: Systemic lupus erythematosus (SLE) is an autoimmune disease driven by immune dysregulation. Parabens, commonly used preservatives, are potential environmental factors that may influence immune function and con...
Coenzyme Q10 as an adjunctive strategy to reduce paclitaxel-induced toxicities in breast cancer: a randomized controlled trial [0.03%]
辅酶Q10作为减少乳腺癌患者紫杉醇诱导毒性的辅助策略：一项随机对照试验
Gehad Hassoub,Noha A El-Bassiouny,Yasser Abdelkader et al.
Gehad Hassoub et al.
Background: Paclitaxel is an effective chemotherapeutic agent for breast cancer, but its use is often limited by cumulative toxicities linked to mitochondrial dysfunction and oxidative stress. This study investigated whet...