The Role and Importance of Procalcitonin (PCT) Testing in Rational Antibiotic Prescribing and Antibiotic Stewardship Programs [0.03%]
促细胞角蛋白测定在合理抗菌药物使用和抗生素管理项目中的作用和重要性
Alireza Abdollahi,Aysan Nozheh,Kimia Mozahheb Yousefi et al.
Alireza Abdollahi et al.
Introduction: Antibiotic resistance is a critical global health issue, primarily driven by inappropriate antibiotic prescribing. Identifying reliable biomarkers to guide antibiotic use is essential to combat this challeng...
Effect of Respiratory Syncytial Virus on the Global Burden of Lower Respiratory Infections: Lessons From the Global Burden of Disease Study 1990-2021 [0.03%]
全球疾病负担研究（1990-2021）对呼吸道合胞病毒造成下呼吸道感染疾病负担的影响分析
Jiafen Zhao,Tao Zhou,Cheng Jiang et al.
Jiafen Zhao et al.
Background: Respiratory syncytial virus (RSV) is a major cause of lower respiratory infections (LRIs), especially in children, the elderly, and immunocompromised individuals. ...
Extracellular Vesicles: A Mailcoach From Mast Cell to Other Cell Species [0.03%]
细胞外囊泡：肥大细胞与其他细胞间交流的信使教练
Bingqi Zhang,Yueshan Sun,Tao Jiang et al.
Bingqi Zhang et al.
Background: Mast cells (MCs) are pivotal immune cells. Beyond soluble mediators, mast cell-derived extracellular vesicles (MC-EVs) are crucial for intercellular communication. MC-EV heterogeneity, influenced by cellular a...
Predictive Role of Serum Inflammatory Markers in Metastatic Luminal A/B Breast Cancers Receiving CDK-4/6 Inhibitors Therapy [0.03%]
循环炎症因子标志物在CDK4/6抑制剂治疗的转移性 luminalA/B型乳腺癌中预后的预测价值
Nilufer Bulut,Tanju Kapagan,Aykut Ozmen et al.
Nilufer Bulut et al.
Background: We conducted this study to evaluate the impact of serum inflammatory markers and histopathological features on prognosis in metastatic hormone receptor positive breast cancer patients treated with first line C...
Linking Mitochondrial Dysfunction to the Immune Microenvironment in HFpEF: An Integrated Bioinformatics and Experimental Approach [0.03%]
心力衰竭射血分数保留与线粒体功能障碍及免疫微环境之间的联系：生物信息学和实验方法的综合应用研究
Yingying Xie,Haoming He,Yike Li et al.
Yingying Xie et al.
Background: The interplay between mitochondrial dysfunction and immune infiltration in heart failure with preserved ejection fraction (HFpEF) remains poorly understood. This study aimed to elucidate this relationship and ...
Vascular Endothelial Growth Factor/Angiopoietin-2 Bispecific Antibody-Induced Vascular Normalization: From Basic Mechanisms to Therapeutic Applications in Breast Cancer [0.03%]
血管内皮生长因子/血小板源性生长因子双特异性抗体诱导的血管正常化：从基础机制到乳腺癌治疗应用
Meng Li,Fengjuan Han,Shuang Ling et al.
Meng Li et al.
Abnormal tumor vasculature is a hallmark of breast cancer, characterized by tortuous, hyperpermeable, and poorly perfused vessels that contribute to hypoxia, therapeutic resistance, and immune exclusion. Vascular endothelial growth factor (...
Vanyo Mitev,Tsanko Mondeshki,Ani Miteva et al.
Vanyo Mitev et al.
Introduction: Despite extensive efforts to identify effective treatments for COVID-19, preventive strategies remain essential. Bromhexine hydrochloride (BRH), an over-the-counter mucolytic with potential TMPRSS2 inhibitio...
Anna Kovchun,Ayse Füsun Kalpaklioglu
Anna Kovchun
Background: Psychological stress is increasingly recognized as an important modifier of asthma severity and control. However, objective clinical data on asthma outcomes during prolonged armed conflict remain limited. This...
Observational Study
Immunity, inflammation and disease. 2026 Apr;14(4):e70447. DOI:10.1002/iid3.70447 2026
ADAMTS2 Modulates Inflammation, Autophagy, and Barrier Integrity Through PI3K/AKT/mTOR Signaling in LPS-Induced Acute Respiratory Distress Syndrome [0.03%]
ADAMTS2通过PI3K/AKT/mTOR信号传导调节内毒素诱导的急性肺损伤中的炎症、自噬和屏障完整性
Song Gao,Ting Lyu,Youhong Quan et al.
Song Gao et al.
Background: Excessive inflammation and alveolar barrier dysfunction are commonly observed in acute respiratory distress syndrome (ARDS). ADAMTS2 is an ECM-remodeling metalloproteinase with emerging immunomodulatory roles ...
Fabiano Pinheiro da Silva,Francisco Garcia Soriano,Ludhmila Abrahão Hajjar
Fabiano Pinheiro da Silva
Introduction: Antimicrobial peptides (AMPs) are essential components of the innate immune system, exhibiting diverse mechanisms of action. Objective: ...