Regulation of PD-1PD-L1 Immune Checkpoints by Gut Microbiota Metabolites and Their Clinical Translational Research: A Review [0.03%]
肠道菌群代谢产物调节PD-1/PD-L1免疫检查点及其临床转化研究进展：一篇综述
Xuanyou Fang,Shuai Yuan,Weijian Mai
Xuanyou Fang
Background: Immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 pathway have revolutionized cancer immunotherapy, yet their clinical benefit is constrained by variable response rates and immune-related adverse ev...
Clinical Feasibility and Safety of Nasal Allergen Provocation Testing in Pediatric Allergic Rhinitis [0.03%]
儿童过敏性鼻炎经鼻变应原激发测试的临床可行性及安全性
Mei-Lan Wang,Terese Huiying Low,Zheng-Cai Li et al.
Mei-Lan Wang et al.
Background: Nasal allergen provocation testing (NAPT) has been shown to be a safe and reproducible test in adults; however, pediatric data are limited. This study aims to investigate the clinical applications, feasibility...
Takayasu Arteritis and Giant Cell Arteritis: Results From a Cross-Sectional Study of 96 Italian Patients [0.03%]
意大利96例塔克津动脉炎和巨细胞动脉炎患者的临床特点及治疗反应
Marcella Prete,Nicola Susca,Elvira Favoino et al.
Marcella Prete et al.
Background: Whether Takayasu arteritis (TAK) and giant cell arteritis (GCA), the most common forms of large-vessel vasculitis (LVV), are distinct clinical entities or different manifestations of the same disease is an ong...
Multicenter Study
Immunity, inflammation and disease. 2026 Jul;14(7):e70489. DOI:10.1002/iid3.70489 2026
The Diagnostic Challenge of Crohn's Disease With Initial Duodenal Involvement: Two Cases and Literature Review [0.03%]
初始十二指肠受累克罗恩病的诊断难题：2例报道及文献复习
Chaochao Chen,Yongrong Li,Yiyao Chen et al.
Chaochao Chen et al.
Background: Upper gastrointestinal Crohn's disease (UGI-CD) is rare, with an adult prevalence of 0.5%-4.0%. Its nonspecific symptomatology and the absence of clear diagnostic guidelines pose significant diagnostic challen...
A Case-Control Study of Factor V Leiden G1691A and MTHFR A1298C Polymorphisms and Clinical Outcomes in Patients With COVID-19 [0.03%]
COVID-19患者中因子V莱顿G1691A和MTHFR A1298C基因多态性与临床结局的病例对照研究
Hilal Çıralıoğlu,Yasemin Adalı,Mert Özen et al.
Hilal Çıralıoğlu et al.
Objective: The clinical relevance of inherited thrombophilia-related polymorphisms in COVID-19 remains uncertain. This study investigated the distribution of Factor V Leiden (FVL) G1691A and MTHFR A1298C polymorphisms in ...
Chandipura Virus: An Emerging Neurological Threat Transmitted by Sandflies in India [0.03%]
印度通过沙蝇传播的新兴神经威胁——chandipura病毒
Abrar Ahmad Zargar,Reena Gupta,P Krishnamoorthy
Abrar Ahmad Zargar
Background: Chandipura virus (CHPV), a neurotropic, negative-sense RNA virus belonging to the genus Vesiculovirus (family Rhabdoviridae), has emerged as a significant cause of acute encephalitis syndrome (AES) in India, p...
Association of C-Reactive Protein-Triglyceride Glucose Index and TyG Index With Prehypertension and Hypertension [0.03%]
C-反应蛋白-甘油三酯-血糖指数和TyG指数与临界高血压和高血压的关系
Shijie Yang,Yuqing Zhang,Zhanyang Zhou et al.
Shijie Yang et al.
This study aimed to investigate the associations of the C-reactive protein-triglyceride glucose index (CTI) and the triglyceride-glucose (TyG) index with prehypertension and hypertension in a Chinese population aged 45 years and older. Base...
Mometasone Furoate Alleviates PM2.5-Induced Pyroptosis of Nasal Mucosa Cells via Blocking JAK2/STAT3/AIM2 Inflammasome [0.03%]
莫米松糠酸酯通过阻断JAK2/STAT3/AIM2炎性小体来缓解PM2.5诱导的鼻粘膜细胞焦亡
Bin Shi,Zhiqi Liu,Ge Le
Bin Shi
Objective: Mometasone furoate (MF) is a widely used intranasal corticosteroid for the management of allergic and non-allergic rhinitis. Recent evidence suggests that its therapeutic efficacy may involve mechanisms beyond ...
TRPM2 Deficiency Attenuates Allergic Rhinitis-Like Inflammation With Altered Ca2+-NFAT Signaling, Treg Responses, and sIgE Production [0.03%]
TRPM2缺陷通过改变Ca2+-NFAT信号、Tregs反应和sIgE产生来缓解类似过敏性鼻炎的炎症反应
Zhenke Huang,Jianping Fan,Xinxin Shan et al.
Zhenke Huang et al.
Background: Allergic rhinitis (AR) is a prevalent chronic inflammatory condition characterized by nasal itching, sneezing, and congestion, significantly impairing patients' quality of life. Despite the availability of var...
Protective Effects of Hyperoside on Type 2 Diabetes Through the Regulation of Pancreatic β-cell Function [0.03%]
槲皮素通过调节胰岛β细胞功能防治2型糖尿病的作用研究
Yuanyuan Jia,Yincui Ai,Fei Lin
Yuanyuan Jia
Background: Type 2 diabetes mellitus (T2D) is a prevalent chronic disease characterized by pancreatic β-cell loss induced by hyperglycemia. Effective treatments to repair β-cell damage remain unclear. Hyperoside, a flav...