The Bufei Nashen Pill Alleviates COPD by Targeting Endoplasmic Reticulum Stress Through the PERK/eIF2α Signaling Pathway [0.03%]
Tengfei He,Anni Zhang,Changxi Zhang
Tengfei He
Background: Evidence supporting the therapeutic efficacy of Bufei Nashen pill (BFNSP) for chronic obstructive pulmonary disease (COPD) is currently limited. We evaluated BFNSP's effects on COPD progression and elucidated ...
Exosomal miR-1246 in Syphilis Serofast State: Diagnostic Value and NLRP3 Inflammasome Suppression [0.03%]
Yue Mou,Caifeng He,Fanxiang Wang et al.
Yue Mou et al.
Background: Serofast state (SF), defined as persistent low-titer antibodies after treatment, poses a diagnostic challenge because of the overlap with serologic features of active infection. Exosomal miRNAs are stable in b...
Relationship Between IL6/IL10 Serum Concentrations and Organ Function in Critically Ill Patients Based on Sepsis: A Prospective Study [0.03%]
Guang-Jian Wang,Hui Lian,Hong-Min Zhang et al.
Guang-Jian Wang et al.
Background: Critical illnesses, particularly sepsis with accompanying organ dysfunction, significantly increase patient mortality. The imbalance between pro-inflammatory and anti-inflammatory responses is closely linked t...
A Nomogram Based on the Castelli Risk Index for Predicting Prognosis in Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention: A Cohort Study [0.03%]
Yan Liu,Ge Song,Ying Zhang et al.
Yan Liu et al.
Background and aims: Composite lipid indices are closely related to the risk and poor prognosis of diseases. However, there are no studies on the prognostic value of Castelli's risk indices-I and II (CRI-I, CRI-II) in pat...
Identification of Prognostic Values of Neutrophil Extracellular Traps-Related Genes in Glioma Based on Bioinformatics [0.03%]
Xiaobing Guo,Xiaowen Li,Hengxi Li et al.
Xiaobing Guo et al.
Background: Glioma is a highly invasive and drug-resistant malignant primary tumor. Increasing research is focusing on the function of neutrophil extracellular traps (NETs) in glioma progress. We aimed to explore the mech...
Post-COVID-19 Area Postrema Syndrome With SARS-CoV-2 in CSF: A Dual-Case Report and Review of the Literature [0.03%]
Wan Zhu,Jing Qian,Min Peng et al.
Wan Zhu et al.
Background: Neuromyelitis optica spectrum disorder (NMOSD) is a rare autoimmune astrocytopathy characterized by inflammatory demyelinating lesions in the central nervous system. Area postrema syndrome (APS), marked by int...
Hyperoside Modulates the Estrogen-PI3K/VEGF Axis to Ameliorate Oxidative Damage-Induced Inhibition of Bone Formation in MC3T3-E1 Cells [0.03%]
Shuo Wang,Wei Feng,Xueqin Feng et al.
Shuo Wang et al.
Objective: This study aims to investigate how hyperoside (HYP) alleviates oxidative stress-induced osteoporosis, its molecular mechanisms, and its impact on osteoblast differentiation, oxidative damage, and the estrogen-P...
Clinical Value the Neutrophil CD64 Index in Predicting the Severity of Hemorrhagic Fever With Renal Syndrome [0.03%]
Chuantao Ye,Rongrong Zhang,Shasha Wu et al.
Chuantao Ye et al.
Objective: The hemorrhagic fever with renal syndrome (HFRS) is an acute viral infectious disease characterized by multi-system damage involving complex mechanisms. Effective identification of critically ill patients is es...
Polydatin Relieves Airway Remodeling by Inhibiting P2X7R-NLRP3-Mediated Excessive Autophagy in Asthma [0.03%]
Guangxing Li,Liangchang Li,Zhiguang Wang et al.
Guangxing Li et al.
Background: Asthma is characterized by chronic airway inflammation and remodeling. Polydatin (PD), a natural compound, has shown anti-inflammatory potential, but its role in asthma-related airway remodeling and the underl...
Ginkgolide B Alleviates Airway Inflammation in Hyperoxia Lung Injury [0.03%]
银杏内酯B缓解 hyperoxia诱导的肺损伤中小鼠气道炎症反应的作用及机制研究
Xuesong Wang,Mingwu Chen,Yong Lv et al.
Xuesong Wang et al.
Background: Bronchopulmonary dysplasia (BPD) is a chronic lung disease characterized by inflammation, often caused by prolonged hyperoxia exposure in preterm infants. Platelet-activating factor (PAF) is a potent inflammat...