Unraveling CRP/cAMP-mediated metabolic regulation in Escherichia coli persister cells [0.03%]
解开CRP/cAMP介导的幽门螺杆菌休眠细胞代谢调节网络
Han G Ngo,Sayed Golam Mohiuddin,Aina Ananda et al.
Han G Ngo et al.
A substantial gap persists in our comprehension of how bacterial metabolism undergoes rewiring during the transition to a persistent state. Also, it remains unclear which metabolic mechanisms become indispensable for persister cell survival...
Forward genetics in C. elegans reveals genetic adaptations to polyunsaturated fatty acid deficiency [0.03%]
正向遗传学在C. elegans中揭示了多不饱和脂肪酸缺乏的遗传适应性
Delaney Kaper,Uroš Radović,Per-Olof Bergh et al.
Delaney Kaper et al.
Polyunsaturated fatty acids (PUFAs) are essential for mammalian health and function as membrane fluidizers and precursors for signaling lipids, though the primary essential function of PUFAs within organisms has not been established. Unlike...
Rachana W Vaidya,Simon Y Tang
Rachana W Vaidya
Platelet-derived growth factors can restore the proliferative potential of senescent cells taken from the degenerated intervertebral discs of aged humans. ...
Editorial
eLife. 2025 Jul 8:14:e107777. DOI:10.7554/eLife.107777 2025
Function and firing of the Streptomyces coelicolor contractile injection system requires the membrane protein CisA [0.03%]
链霉菌素紫蓝素菌的收缩注射系统的功能和启动需要跨膜蛋白CisA
Bastien Casu,Joseph W Sallmen,Peter E Haas et al.
Bastien Casu et al.
Bacterial contractile injection systems (CIS) are phage tail-like macromolecular complexes that mediate cell-cell interactions by injecting effector proteins into target cells. CIS from Streptomyces coelicolor (CISSc) are localized in the c...
Epithelial cell chirality emerges through the dynamic concentric pattern of actomyosin cytoskeleton [0.03%]
上皮细胞手性通过动态同心排列的肌动蛋白皮层模式产生
Takaki Yamamoto,Tomoki Ishibashi,Yuko Mimori-Kiyosue et al.
Takaki Yamamoto et al.
The chirality of tissues and organs is essential for their proper function and development. Tissue-level chirality derives from the chirality of individual cells that comprise the tissue, and cellular chirality is considered to emerge throu...
Homophilic wiring principles underpin neuronal network topology in vitro [0.03%]
同质性接线原则是离体神经网络拓扑的基础
Danyal Akarca,Alexander W E Dunn,Philipp J Hornauer et al.
Danyal Akarca et al.
Economic efficiency has been a popular explanation for how networks self-organize within the developing nervous system. However, the precise nature of the economic negotiations governing this putative organizational principle remains unclea...
Quantitative intra-Golgi transport and organization data suggest the stable compartment nature of the Golgi [0.03%]
定量的细胞内质网运输和组织数据表明细胞内质网具有稳定 compartments性质
Hieng Chiong Tie,Haiyun Wang,Divyanshu Mahajan et al.
Hieng Chiong Tie et al.
How the intra-Golgi secretory transport works remains a mystery. The cisternal progression and the stable compartment models have been proposed and are under debate. Classic cisternal progression model posits that both the intra-Golgi trans...
β-Glucan reprograms alveolar macrophages via neutrophil/IFNγ axis in a murine model of lung injury [0.03%]
β-葡聚糖通过中性粒细胞/干扰素-γ轴重编程肺泡巨噬细胞以修复小鼠肺损伤模型中的气道屏障功能
Renaud Prevel,Erwan Pernet,Kim A Tran et al.
Renaud Prevel et al.
Alveolar macrophages (AMs) reside in the lower airways and play a crucial role in lung health and response to sterile inflammation and infections. AMs possess remarkable adaptability to different environmental challenges that can persist th...
Duncan S Mearns,Sydney A Hunt,Martin W Schneider et al.
Duncan S Mearns et al.
Animal behavior is adapted to the sensory environment in which it evolved, while also being constrained by physical limits, evolutionary history, and developmental trajectories. The hunting behavior of larval zebrafish (Danio rerio), a cypr...
The C-terminus of the multi-drug efflux pump EmrE prevents proton leak by gating transport [0.03%]
EmrE多药外排泵的C端结构域通过闸门机制防止质子泄漏
Merissa Brousseau,Da Teng,Nathan E Thomas et al.
Merissa Brousseau et al.
The model multi-drug efflux pump from Escherichia coli, EmrE, can perform multiple types of transport leading to different biological outcomes, conferring resistance to some drug substrates and enhancing susceptibility to others. While tran...