Martik Chatterjee,Xin Yi Yu,Noah K Brady et al.
Martik Chatterjee et al.
Insect wings, a key innovation that contributed to the explosive diversification of insects, are recognized for their remarkable variation and many splendid adaptations. Classical morphological work subdivides insect wings into several dist...
Hypothermia protects against ventilator-induced lung injury by limiting IL-1β release and NETs formation [0.03%]
低温通过限制IL-1β释放和NET形成来预防机械通气引起的肺损伤
Nobuyuki Nosaka,Vanessa Borges,Daisy Martinon et al.
Nobuyuki Nosaka et al.
Although mechanical ventilation is a critical intervention for acute respiratory distress syndrome (ARDS), it can trigger an IL-1β-associated complication known as ventilator-induced lung injury. In mice, we found that lipopolysaccharide (...
Enhui Xie,Shuyi Zha,Yiyang Xu et al.
Enhui Xie et al.
Group identification may influence collective behaviors and result in variations in collective performance. However, the evidence for this hypothesis and the neural mechanisms involved remain elusive. To this end, we conducted a study using...
Striatal cholinergic interneuron pause response requires Kv1 channels, is absent in dyskinetic mice, and is restored by dopamine D5 receptor inverse agonism [0.03%]
黑质纹状体多巴胺能神经元的电生理学和遗传小鼠研究：伏隔核胆碱能中间神经元暂停反应需要Kv1通道，在异动症小鼠中缺失，并可通过多巴胺D5受体反向激动剂恢复
Cecilia Tubert,Rodrigo Manuel Paz,Agostina Mónica Stahl et al.
Cecilia Tubert et al.
Striatal cholinergic interneurons (SCINs) exhibit pause responses conveying information about rewarding events, but the mechanisms underlying these pauses remain elusive. Thalamic inputs induce a pause mediated by intrinsic mechanisms and r...
Yan Cui,Evgeny Bondarenko,Carolina Thörn Perez et al.
Yan Cui et al.
We explored neural mechanisms underlying sighing in mice. Photostimulation of parafacial (pF) neuromedin B (NMB) or gastrin-releasing peptide (GRP), or preBötzinger Complex (preBötC) NMBR or GRPR neurons elicited ectopic sighs with latenc...
Nonequilibrium polysome dynamics promote chromosome segregation and its coupling to cell growth in Escherichia coli [0.03%]
非平衡多核糖体动力学促进大肠杆菌染色体分离及其与细胞生长的偶联作用
Alexandros Papagiannakis,Qiwei Yu,Sander K Govers et al.
Alexandros Papagiannakis et al.
Chromosome segregation is essential for cellular proliferation. Unlike eukaryotes, bacteria lack cytoskeleton-based machinery to segregate their chromosomal DNA (nucleoid). The bacterial ParABS system segregates the duplicated chromosomal r...
TRPV4 activation by TGFβ2 enhances cellular contractility and drives ocular hypertension [0.03%]
TGFβ2激活TRPV4促进细胞收缩并诱导眼压升高
Christopher Nass Rudzitis,Monika Lakk,Ayushi Singh et al.
Christopher Nass Rudzitis et al.
The risk for developing primary open-angle glaucoma (POAG) correlates with the magnitude of ocular hypertension (OHT) and the concentration of transforming growth factor-β2 (TGFβ2) in the aqueous humor. Effective treatment of POAG require...
The triad interaction of ULK1, ATG13, and FIP200 is required for ULK complex formation and autophagy [0.03%]
ULK1、ATG13和FIP200的三元相互作用要求ULK复合体形成及自噬发生
Yutaro Hama,Yuko Fujioka,Hayashi Yamamoto et al.
Yutaro Hama et al.
In mammals, autophagosome formation, a central event in autophagy, is initiated by the ULK complex comprising ULK1/2, FIP200, ATG13, and ATG101. However, the structural basis and mechanism underlying the ULK complex assembly have yet to be ...
Neural dynamics of visual working memory representation during sensory distraction [0.03%]
感觉干扰下的视觉工作记忆神经动力学
Jonas Karolis Degutis,Simon Weber,Joram Soch et al.
Jonas Karolis Degutis et al.
Recent studies have provided evidence for the concurrent encoding of sensory percepts and visual working memory (VWM) contents across visual areas; however, it has remained unclear how these two types of representations are concurrently pre...
Swagata Halder,Deepak Velgapuni Raya,Devarajan Sridharan
Swagata Halder
The attentional blink reflects a ubiquitous bottleneck with selecting and processing the second of two targets that occur in close temporal proximity. An extensive literature has examined the attention blink as a unitary phenomenon. As a re...