Female-germline specific protein Sakura interacts with Otu and is crucial for germline stem cell renewal and differentiation and oogenesis [0.03%]
Azali Azlan,Li Zhu,Ryuya Fukunaga
Azali Azlan
During oogenesis, self-renewal and differentiation of germline stem cells (GSCs) must be tightly regulated. The Drosophila female germline serves as an excellent model for studying these regulatory mechanisms. Here, we report that a previou...
Human formin FHOD3-mediated actin elongation is required for sarcomere integrity in cardiomyocytes [0.03%]
Dylan A Valencia,Angela N Koeberlein,Haruko Nakano et al.
Dylan A Valencia et al.
Contractility and cell motility depend on accurately controlled assembly of the actin cytoskeleton. Formins are a large group of actin assembly proteins that nucleate and elongate new actin filaments. Some formins may cap filaments while ot...
Opposing regulation of TNF responses by IFN-γ and a PGE2-cAMP axis that is apparent in rheumatoid and immune checkpoint inhibitor-induced arthritis human IL-1β+ macrophages [0.03%]
Upneet K Sokhi,Ruoxi Yuan,Bikash Mishra et al.
Upneet K Sokhi et al.
IL-1β-expressing macrophages have been described in rheumatoid arthritis (RA), immune checkpoint inhibitor-induced inflammatory arthritis (ICI-arthritis), and pancreatic cancer and proposed to be pathogenic. IL-1β+ macrophages express gen...
Joshua D Garcia,Chenyu Wang,Ryan P D Alexander et al.
Joshua D Garcia et al.
Mature neocortical pyramidal cells functionally express two sodium channel (NaV) isoforms: NaV1.2 and NaV1.6. These isoforms are differentially localized to pyramidal cell compartments, and as such are thought to contribute to different asp...
A mathematical model for ketosis-prone diabetes suggests the existence of multiple pancreatic β-cell inactivation mechanisms [0.03%]
Sean A Ridout,Priyathama Vellanki,Ilya Nemenman
Sean A Ridout
Ketosis-prone diabetes mellitus (KPD) is a subtype of type 2 diabetes, which presents much like type 1 diabetes, with dramatic hyperglycemia and ketoacidosis. Although KPD patients are initially insulin-dependent, after a few months of insu...
Malnutrition drives infection susceptibility and dysregulated myelopoiesis that persists after refeeding intervention [0.03%]
Alisa Sukhina,Clemence Queriault,Saptarshi Roy et al.
Alisa Sukhina et al.
Undernutrition remains a major global health crisis, with nearly 1 billion people experiencing severe food insecurity. Malnourished individuals are especially vulnerable to infectious diseases, which is the leading cause of morbidity and mo...
EPHA4 signaling dysregulation links abnormal locomotion and the development of idiopathic scoliosis [0.03%]
Lianlei Wang,Xinyu Yang,Sen Zhao et al.
Lianlei Wang et al.
Idiopathic scoliosis (IS) is the most common form of spinal deformity with unclear pathogenesis. In this study, we first reanalyzed the loci associated with IS, drawing upon previous studies. Subsequently, we mapped these loci to candidate ...
Benjamin Allen
Benjamin Allen
A theoretical framework for analyzing the evolution of nonlinear cooperative interactions is taking shape. Keywords: ...
Editorial
eLife. 2025 Jul 15:14:e108039. DOI:10.7554/eLife.108039 2025
Elliot Howard-Spink,Tetsuro Matsuzawa,Susana Carvalho et al.
Elliot Howard-Spink et al.
We know vanishingly little about how long-lived apes experience senescence in the wild, particularly with respect to their foraging behaviors. Chimpanzees use tools during foraging, and given the cognitive and physical challenges presented ...
S100a4+ alveolar macrophages accelerate the progression of precancerous atypical adenomatous hyperplasia by promoting the angiogenic function regulated by fatty acid metabolism [0.03%]
Hong Huang,Ying Yang,Qiuju Zhang et al.
Hong Huang et al.
Lung cancer is preceded by premalignant lesions, and what factors drive this transformation and the potential regulatory mode in the context of tumor initiation remain to be elucidated. In the course of precancerous lesions in mice, we foun...