Inflammation-related collagen fibril destruction contributes to temporomandibular joint disc displacement via NF-κB activation [0.03%]
NF-κB激活介导的炎性降解胶原纤维参与翼外肌炎性反应致颞下颌关节盘移位的病理过程
Shengjie Cui,Yanning Guo,Yu Fu et al.
Shengjie Cui et al.
Temporomandibular joint (TMJ) disc displacement is one of the most significant subtypes of temporomandibular joint disorders, but its etiology and mechanism are poorly understood. In this study, we elucidated the mechanisms by which destruc...
NUP62 alleviates senescence and promotes the stemness of human dental pulp stem cells via NSD2-dependent epigenetic reprogramming [0.03%]
NUP62通过NSD2依赖的表观遗传重编程缓解人类牙髓干细胞衰老并促进其干细胞特性
Xiping Wang,Li Wang,Linxi Zhou et al.
Xiping Wang et al.
Stem cells play a crucial role in maintaining tissue regenerative capacity and homeostasis. However, mechanisms associated with stem cell senescence require further investigation. In this study, we conducted a proteomic analysis of human de...
Dimethyl fumarate modulates M1/M2 macrophage polarization to ameliorate periodontal destruction by increasing TUFM-mediated mitophagy [0.03%]
富马酸二甲酯通过增加TUFM介导的线粒体自噬来调节M1 / M2巨噬细胞极化以缓解牙周破坏
Liang Chen,Pengxiao Hu,Xinhua Hong et al.
Liang Chen et al.
Periodontitis is a common oral disease characterized by progressive alveolar bone resorption and inflammation of the periodontal tissues. Dimethyl fumarate (DMF) has been used in the treatment of various immune-inflammatory diseases due to ...
Lysine-specific demethylase 1 controls key OSCC preneoplasia inducer STAT3 through CDK7 phosphorylation during oncogenic progression and immunosuppression [0.03%]
组蛋白去甲基化酶KDM1通过CDK7磷酸化调控STAT3在头颈部鳞癌发生发展及免疫抑制中的作用机制研究
Amit Kumar Chakraborty,Rajnikant Dilip Raut,Kisa Iqbal et al.
Amit Kumar Chakraborty et al.
Oral squamous cell carcinoma (OSCC) progresses from preneoplastic precursors via genetic and epigenetic alterations. Previous studies have focused on the treatment of terminally developed OSCC. However, the role of epigenetic regulators as ...
Fibroblast derived C3 promotes the progression of experimental periodontitis through macrophage M1 polarization and osteoclast differentiation [0.03%]
成纤维细胞衍生的补体C3通过促进巨噬细胞M1极化和破骨细胞分化来促进实验性牙周炎的发展
Feilong Ren,Shize Zheng,Huanyu Luo et al.
Feilong Ren et al.
Complement C3 plays a critical role in periodontitis. However, its source, role and underlying mechanisms remain unclear. In our study, by analyzing single-cell sequencing data from mouse model of periodontitis, we identified that C3 is pri...
Programmed death-ligand 1 regulates ameloblastoma growth and recurrence [0.03%]
程序性死亡配体1调节成釉细胞瘤的生长和复发
Linzhou Zhang,Hao Lin,Jiajie Liang et al.
Linzhou Zhang et al.
Tumor cell-intrinsic programmed death-ligand 1 (PD-L1) signals mediate tumor initiation, progression and metastasis, but their effects in ameloblastoma (AM) have not been reported. In this comprehensive study, we observed marked upregulatio...
Expert consensus on orthodontic treatment of patients with periodontal disease [0.03%]
牙周病患者的正畸治疗专家共识
Wenjie Zhong,Chenchen Zhou,Yuanyuan Yin et al.
Wenjie Zhong et al.
Patients with periodontal disease often require combined periodontal-orthodontic interventions to restore periodontal health, function, and aesthetics, ensuring both patient satisfaction and long-term stability. Managing these patients invo...
Exploring the mechanical and biological interplay in the periodontal ligament [0.03%]
探究牙周膜中的机械与生物相互作用
Xinyu Wen,Fang Pei,Ying Jin et al.
Xinyu Wen et al.
The periodontal ligament (PDL) plays a crucial role in transmitting and dispersing occlusal force, acting as mechanoreceptor for muscle activity during chewing, as well as mediating orthodontic tooth movement. It transforms mechanical stimu...
Xin Zhou,Si Chen,Chenchen Zhou et al.
Xin Zhou et al.
The prevalence of Class III malocclusion varies among different countries and regions. The populations from Southeast Asian countries (Chinese and Malaysian) showed the highest prevalence rate of 15.8%, which can seriously affect oral funct...
Expert consensus on imaging diagnosis and analysis of early correction of childhood malocclusion [0.03%]
儿童期错
Zitong Lin,Chenchen Zhou,Ziyang Hu et al.
Zitong Lin et al.
Early correction of childhood malocclusion is timely managing morphological, structural, and functional abnormalities at different dentomaxillofacial developmental stages. The selection of appropriate imaging examination and comprehensive r...