METTL7A-mediated m6A modification of corin reverses bisphosphonates-impaired osteogenic differentiation of orofacial BMSCs [0.03%]
METTL7A介导的corinm6A甲基化逆转双磷酸盐对头面部BMSCs成骨分化的抑制作用
Yizhou Jin,Xiao Han,Yuejun Wang et al.
Yizhou Jin et al.
Bisphosphonate-related osteonecrosis of jaw (BRONJ) is characterized by impaired osteogenic differentiation of orofacial bone marrow stromal cells (BMSCs). Corin has recently been demonstrated to act as a key regulator in bone development a...
Multiomics profiling reveals VDR as a central regulator of mesenchymal stem cell senescence with a known association with osteoporosis after high-fat diet exposure [0.03%]
多组学谱分析揭示了VDR是高脂肪饮食暴露后与骨质疏松症有关的间充质干细胞衰老的中心调节因子
Jiayao Chen,Shuhong Kuang,Jietao Cen et al.
Jiayao Chen et al.
The consumption of a high-fat diet (HFD) has been linked to osteoporosis and an increased risk of fragility fractures. However, the specific mechanisms of HFD-induced osteoporosis are not fully understood. Our study shows that exposure to a...
Human dental pulp stem cells mitigate the neuropathology and cognitive decline via AKT-GSK3β-Nrf2 pathways in Alzheimer's disease [0.03%]
人源牙髓间充质干细胞通过AKT-GSK3β-Nrf2信号通路改善阿尔茨海默病的神经病理和认知障碍反应
Wei Xiong,Ye Liu,Heng Zhou et al.
Wei Xiong et al.
Oxidative stress is increasingly recognized as a major contributor to the pathophysiology of Alzheimer's disease (AD), particularly in the early stages of the disease. The multiplicity advantages of stem cell transplantation make it fascina...
Unveiling the oral-gut connection: chronic apical periodontitis accelerates atherosclerosis via gut microbiota dysbiosis and altered metabolites in apoE-/- Mice on a high-fat diet [0.03%]
揭示口腔-肠道联系：慢性根尖周炎通过肠道菌群失调和改变的代谢物加速高脂饮食Apoe基因敲除小鼠动脉粥样硬化的发展
Guowu Gan,Shihan Lin,Yufang Luo et al.
Guowu Gan et al.
The aim of this study was to explore the impact of chronic apical periodontitis (CAP) on atherosclerosis in apoE-/- mice fed high-fat diet (HFD). This investigation focused on the gut microbiota, metabolites, and intestinal barrier function...
Sinensetin protects against periodontitis through binding to Bach1 enhancing its ubiquitination degradation and improving oxidative stress [0.03%]
.Sinensetin通过与Bach1结合促进其泛素化降解来保护牙周病并改善氧化应激
Zhiyao Yuan,Junjie Li,Fuyu Xiao et al.
Zhiyao Yuan et al.
Periodontitis is a chronic inflammatory and immune reactive disease induced by the subgingival biofilm. The therapeutic effect for susceptible patients is often unsatisfactory due to excessive inflammatory response and oxidative stress. Sin...
A 3D In-vitro model of the human dentine interface shows long-range osteoinduction from the dentine surface [0.03%]
一种人类牙本质界面的三维体外模型显示牙本质表面具有远程成骨诱导性
William Macalester,Asme Boussahel,Rafael O Moreno-Tortolero et al.
William Macalester et al.
Emerging regenerative cell therapies for alveolar bone loss have begun to explore the use of cell laden hydrogels for minimally invasive surgery to treat small and spatially complex maxilla-oral defects. However, the oral cavity presents a ...
m1A inhibition fuels oncolytic virus-elicited antitumor immunity via downregulating MYC/PD-L1 signaling [0.03%]
抑制m1A可促进溶瘤病毒诱发的抗肿瘤免疫应答并下调MYC/PD-L1信号通路
Shujin Li,Tian Feng,Yuantong Liu et al.
Shujin Li et al.
N1-methyladenosine (m1A) RNA methylation is critical for regulating mRNA translation; however, its role in the development, progression, and immunotherapy response of head and neck squamous cell carcinoma (HNSCC) remains largely unknown. Us...
Phenformin activates ER stress to promote autophagic cell death via NIBAN1 and DDIT4 in oral squamous cell carcinoma independent of AMPK [0.03%]
苯乙双胍通过NIBAN1和DDIT4在AMPK非依赖方式中激活内质网应激促进口腔鳞状细胞癌的自噬性细胞死亡
Dexuan Zhuang,Shuangshuang Wang,Huiting Deng et al.
Dexuan Zhuang et al.
The efficient clinical treatment of oral squamous cell carcinoma (OSCC) is still a challenge that demands the development of effective new drugs. Phenformin has been shown to produce more potent anti-tumor activities than metformin on diffe...
Fully automatic AI segmentation of oral surgery-related tissues based on cone beam computed tomography images [0.03%]
基于锥形束CT图像的全自动AI口腔手术相关组织分割方法
Yu Liu,Rui Xie,Lifeng Wang et al.
Yu Liu et al.
Accurate segmentation of oral surgery-related tissues from cone beam computed tomography (CBCT) images can significantly accelerate treatment planning and improve surgical accuracy. In this paper, we propose a fully automated tissue segment...
Transcriptomic and cellular decoding of scaffolds-induced suture mesenchyme regeneration [0.03%]
解码支架诱导颅缝间充质组织再生的转录组和细胞机制
Jiayi Wu,Feifei Li,Peng Yu et al.
Jiayi Wu et al.
Precise orchestration of cell fate determination underlies the success of scaffold-based skeletal regeneration. Despite extensive studies on mineralized parenchymal tissue rebuilding, regenerating and maintaining undifferentiated mesenchyme...