Harnessing the HDAC-histone deacetylase enzymes, inhibitors and how these can be utilised in tissue engineering [0.03%]
组蛋白去乙酰化酶（HDAC）酶、抑制剂及其在组织工程中的应用潜力
Liam Lawlor,Xuebin B Yang
Liam Lawlor
There are large knowledge gaps regarding how to control stem cells growth and differentiation. The limitations of currently available technologies, such as growth factors and/or gene therapies has led to the search of alternatives. We explo...
Compliant substratum modulates vinculin expression in focal adhesion plaques in skeletal cells [0.03%]
顺应性底物调节骨骼细胞焦粘附斑中的vinculin表达
Chenchen Zhou,Qingxuan Wang,Demao Zhang et al.
Chenchen Zhou et al.
The biophysical properties of the extracellular matrix (ECM) dictate tissue-specific cell behaviour. In the skeleton system, bone shows the potential to adapt its architecture and contexture to environmental rigidity via the bone remodellin...
Human genes influence the interaction between Streptococcus mutans and host caries susceptibility: a genome-wide association study in children with primary dentition [0.03%]
人类基因影响牙菌斑致龋细菌与宿主的相互作用：儿童乳牙期的全基因组关联研究
Ying Meng,Tongtong Wu,Ronald Billings et al.
Ying Meng et al.
Streptococcus mutans is a well-known cause of dental caries, due to its acidogenicity, aciduricity, and ability to synthesize exopolysaccharides in dental plaques. Intriguingly, not all children who carry S. mutans manifest caries, even wit...
Recent advances in cell sheet technology for bone and cartilage regeneration: from preparation to application [0.03%]
细胞片在骨和软骨再生领域的研究进展：从制备到应用
Yuezhi Lu,Wenjie Zhang,Jie Wang et al.
Yuezhi Lu et al.
Bone defects caused by trauma, tumour resection, infection and congenital deformities, together with articular cartilage defects and cartilage-subchondral bone complex defects caused by trauma and degenerative diseases, remain great challen...
Mucosal-associated invariant T cells and oral microbiome in persistent apical periodontitis [0.03%]
黏膜相关不变T细胞与持续性根尖周炎的口腔微生物组关系研究
Haleh Davanian,Rogier Aäron Gaiser,Mikael Silfverberg et al.
Haleh Davanian et al.
Opportunistic bacteria in apical periodontitis (AP) may pose a risk for systemic dissemination. Mucosal-associated invariant T (MAIT) cells are innate-like T cells with a broad and potent antimicrobial activity important for gut mucosal int...
Dental remineralization via poly(amido amine) and restorative materials containing calcium phosphate nanoparticles [0.03%]
含钙磷酸纳米粒子聚(氨基胺)和修复材料的牙齿再矿化
Kunneng Liang,Suping Wang,Siying Tao et al.
Kunneng Liang et al.
Tooth decay is prevalent, and secondary caries causes restoration failures, both of which are related to demineralization. There is an urgent need to develop new therapeutic materials with remineralization functions. This article represents...
Qianming Chen,Hongxia Dan,Fan Tang et al.
Qianming Chen et al.
With recent developments in photosensitizers and light delivery systems, topical 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) has become the fourth alternative therapeutic approach in the management of oral leucoplakia (OLK...
Overexpression of Dlx2 enhances osteogenic differentiation of BMSCs and MC3T3-E1 cells via direct upregulation of Osteocalcin and Alp [0.03%]
DLX2过表达通过直接上调骨钙素及碱性磷酸酶促进骨髓间充质干细胞和MC3T3-E1细胞成骨分化
Jianfei Zhang,Wenbin Zhang,Jiewen Dai et al.
Jianfei Zhang et al.
Genetic studies have revealed a critical role of Distal-homeobox (Dlx) genes in bone formation, and our previous study showed that Dlx2 overexpressing in neural crest cells leads to profound abnormalities of the craniofacial tissues. The ai...
Transient receptor potential Vanilloid 1-based gene therapy alleviates orthodontic pain in rats [0.03%]
基于瞬时受体电位香草素1的基因治疗可缓解大鼠牙齿矫正疼痛
Rui Guo,Yang Zhou,Hu Long et al.
Rui Guo et al.
Orthodontic pain that is induced by tooth movement is an important sequela of orthodontic treatment and has a significant effect on patient quality of life. Studies have shown that the high expression of transient receptor potential vanillo...
Oral bacteria colonize and compete with gut microbiota in gnotobiotic mice [0.03%]
口腔细菌定植并竞争无菌小鼠肠道微生物群
Bolei Li,Yang Ge,Lei Cheng et al.
Bolei Li et al.
The oral microbiota is associated with oral diseases and digestive systemic diseases. Nevertheless, the causal relationship between them has not been completely elucidated, and colonisation of the gut by oral bacteria is not clear due to th...