Effect of the sonic hedgehog inhibitor GDC-0449 on an in vitro isogenic cellular model simulating odontogenic keratocysts [0.03%]
GDC-0449对体外同基因细胞模型（模拟成釉细胞囊肿）的影响
Jiemei Zhai,Heyu Zhang,Jianyun Zhang et al.
Jiemei Zhai et al.
Odontogenic keratocysts (OKCs) are common cystic lesions of odontogenic epithelial origin that can occur sporadically or in association with naevoid basal cell carcinoma syndrome (NBCCS). OKCs are locally aggressive, cause marked destructio...
Mirali Pandya,Thomas G H Diekwisch
Mirali Pandya
Tooth enamel is a complex mineralized tissue consisting of long and parallel apatite crystals configured into decussating enamel rods. In recent years, multiple approaches have been introduced to generate or regenerate this highly attractiv...
Long-term dexamethasone treatment diminishes store-operated Ca2+ entry in salivary acinar cells [0.03%]
长效地塞米松治疗降低唾液腺泡细胞内钙离子释放操作性进入现象
Yuichiro Kusuda,Yusuke Kondo,Yuta Miyagi et al.
Yuichiro Kusuda et al.
Corticosteroids are used in the treatment of many diseases; however, they also induce various side effects. Dexamethasone is one of the most potent corticosteroids, and it has been reported to induce the side effect of impaired salivary gla...
Author Correction: Single CD271 marker isolates mesenchymal stem cells from human dental pulp [0.03%]
作者更正：单一CD271标记从人牙髓中分离间充质干细胞
Ruth Alvarez,Hye-Lim Lee,Christine Hong et al.
Ruth Alvarez et al.
In the original version of this Article, Figure 1c was inadvertently assembled with a duplicate of Figure 1b. The correct image for Figure 1c, shown below, has been added in the HTML and PDF versions of the Article. This does not affect the...
Published Erratum
International journal of oral science. 2019 Jan 2;11(1):5. DOI:10.1038/s41368-018-0042-x 2019
Yun Feng,Qian Li,Jiao Chen et al.
Yun Feng et al.
Proteases are important molecules that are involved in many physiological and pathological processes of the human body, such as growth, apoptosis and metastasis cancer cells. They are potential targets in cancer diagnosis and biotherapy. In...
Increased virulence of the oral microbiome in oral squamous cell carcinoma revealed by metatranscriptome analyses [0.03%]
口腔鳞状细胞癌中口腔微生物组的致病性增强——来自元转录组分析的证据
Susan Yost,Philip Stashenko,Yoonhee Choi et al.
Susan Yost et al.
Oral squamous cell carcinoma (OSCC) is the most prevalent and most commonly studied oral cancer. However, there is a void regarding the role that the oral microbiome may play in OSCC. Although the relationship between microbial community co...
The functional significance of dentin sialoprotein-phosphophoryn and dentin sialoprotein [0.03%]
关于牙本质糖蛋白和牙本质涎蛋白的功能意义
Helena Ritchie
Helena Ritchie
Phosphophoryn (PP) and dentin sialoprotein (DSP) are the most dominant non-collagenous proteins in dentin. PP is an extremely acidic protein that can function as a mineral nucleator for dentin mineralization. DSP was first identified in 198...
ERK phosphorylation functions in invadopodia formation in tongue cancer cells in a novel silicate fibre-based 3D cell culture system [0.03%]
新的硅酸盐纤维基三维细胞培养系统中ERK磷酸化在舌癌细胞侵袭小体形成中的作用研究
Masaharu Noi,Ken-Ichi Mukaisho,Saori Yoshida et al.
Masaharu Noi et al.
To screen for additional treatment targets against tongue cancer, we evaluated the contributions of extracellular signal-related kinase (ERK), AKT and ezrin in cancer development. Immunohistochemical staining showed that ERK and ezrin expre...
TGF-β2 downregulates osteogenesis under inflammatory conditions in dental follicle stem cells [0.03%]
TGF-β2在炎症条件下通过抑制牙囊干细胞成骨分化的作用
Soyoun Um,Joo-Hee Lee,Byoung-Moo Seo
Soyoun Um
Bone formation is important for the reconstruction of bone-related structures in areas that have been damaged by inflammation. Inflammatory conditions such as those that occur in patients with rheumatoid arthritis, cystic fibrosis, and peri...
Whole exome sequencing identifies an AMBN missense mutation causing severe autosomal-dominant amelogenesis imperfecta and dentin disorders [0.03%]
全外显子组测序鉴定到一个导致严重常染色体显性遗传的牙本质和牙釉质发育不全的AMBN错义突变
Ting Lu,Meiyi Li,Xiangmin Xu et al.
Ting Lu et al.
Tooth development is a complex process that involves precise and time-dependent orchestration of multiple genetic, molecular, and cellular interactions. Ameloblastin (AMBN, also named "amelin" or "sheathlin") is the second most abundant ena...