Mucosal-associated invariant T cells and oral microbiome in persistent apical periodontitis [0.03%]
黏膜相关不变T细胞与持续性根尖周炎的口腔微生物组关系研究
Haleh Davanian,Rogier Aäron Gaiser,Mikael Silfverberg et al.
Haleh Davanian et al.
Opportunistic bacteria in apical periodontitis (AP) may pose a risk for systemic dissemination. Mucosal-associated invariant T (MAIT) cells are innate-like T cells with a broad and potent antimicrobial activity important for gut mucosal int...
Dental remineralization via poly(amido amine) and restorative materials containing calcium phosphate nanoparticles [0.03%]
含钙磷酸纳米粒子聚(氨基胺)和修复材料的牙齿再矿化
Kunneng Liang,Suping Wang,Siying Tao et al.
Kunneng Liang et al.
Tooth decay is prevalent, and secondary caries causes restoration failures, both of which are related to demineralization. There is an urgent need to develop new therapeutic materials with remineralization functions. This article represents...
Qianming Chen,Hongxia Dan,Fan Tang et al.
Qianming Chen et al.
With recent developments in photosensitizers and light delivery systems, topical 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) has become the fourth alternative therapeutic approach in the management of oral leucoplakia (OLK...
Overexpression of Dlx2 enhances osteogenic differentiation of BMSCs and MC3T3-E1 cells via direct upregulation of Osteocalcin and Alp [0.03%]
DLX2过表达通过直接上调骨钙素及碱性磷酸酶促进骨髓间充质干细胞和MC3T3-E1细胞成骨分化
Jianfei Zhang,Wenbin Zhang,Jiewen Dai et al.
Jianfei Zhang et al.
Genetic studies have revealed a critical role of Distal-homeobox (Dlx) genes in bone formation, and our previous study showed that Dlx2 overexpressing in neural crest cells leads to profound abnormalities of the craniofacial tissues. The ai...
Transient receptor potential Vanilloid 1-based gene therapy alleviates orthodontic pain in rats [0.03%]
基于瞬时受体电位香草素1的基因治疗可缓解大鼠牙齿矫正疼痛
Rui Guo,Yang Zhou,Hu Long et al.
Rui Guo et al.
Orthodontic pain that is induced by tooth movement is an important sequela of orthodontic treatment and has a significant effect on patient quality of life. Studies have shown that the high expression of transient receptor potential vanillo...
Oral bacteria colonize and compete with gut microbiota in gnotobiotic mice [0.03%]
口腔细菌定植并竞争无菌小鼠肠道微生物群
Bolei Li,Yang Ge,Lei Cheng et al.
Bolei Li et al.
The oral microbiota is associated with oral diseases and digestive systemic diseases. Nevertheless, the causal relationship between them has not been completely elucidated, and colonisation of the gut by oral bacteria is not clear due to th...
Defining a critical period in calvarial development for Hedgehog pathway antagonist-induced frontal bone dysplasia in mice [0.03%]
定义 hedgehog 途径拮抗剂诱导的小鼠额骨发育不全的关键时期
Yuanjing Jiang,Shixian Zhang,Chuanqing Mao et al.
Yuanjing Jiang et al.
The Hedgehog (Hh) signalling pathway is essential for cellular proliferation and differentiation during embryonic development. Gain and loss of function of Hh signalling are known to result in an array of craniofacial malformations. To dete...
Chronic inflammation deteriorates structure and function of collagen fibril in rat temporomandibular joint disc [0.03%]
慢性炎症恶化大鼠颞下颌关节盘胶原纤维结构与功能
Sheng-Jie Cui,Yu Fu,Yan Liu et al.
Sheng-Jie Cui et al.
Collagen is the building component of temporomandibular joint (TMJ) discs and is often affected by inflammation in temporomandibular disorders. The macromechanical properties of collagen are deteriorated by chronic inflammation. However, th...
Caffeic acid phenethyl ester protects against oxidative stress and dampens inflammation via heme oxygenase 1 [0.03%]
咖啡酸苯乙酯通过血红素氧合酶1保护氧化应激并抑制炎症反应
Alexandra Stähli,Ceeneena Ubaidha Maheen,Franz Josef Strauss et al.
Alexandra Stähli et al.
Periodontal disease is associated with chronic oxidative stress and inflammation. Caffeic acid phenethyl ester (CAPE), which is a potent inducer of heme oxygenase 1 (HO1), is a central active component of propolis, and the application of pr...
En Luo,Hanghang Liu,Qiucheng Zhao et al.
En Luo et al.
Rare diseases are usually genetic, chronic and incurable disorders with a relatively low incidence. Developments in the diagnosis and management of rare diseases have been relatively slow due to a lack of sufficient profit motivation and ma...