PKD3 promotes metastasis and growth of oral squamous cell carcinoma through positive feedback regulation with PD-L1 and activation of ERK-STAT1/3-EMT signalling [0.03%]
PKD3通过与PD-L1正反馈调节和激活ERK-STAT1 / 3-EMT信号传导来促进口腔鳞状细胞癌的转移和生长
Bomiao Cui,Jiao Chen,Min Luo et al.
Bomiao Cui et al.
Oral squamous cell carcinoma (OSCC) has a high incidence of metastasis. Tumour immunotherapy targeting PD-L1 or PD-1 has been revolutionary; however, only a few patients with OSCC respond to this treatment. Therefore, it is essential to gai...
Shuang Jiang,Rui Sheng,Xingying Qi et al.
Shuang Jiang et al.
Tooth root morphogenesis involves two biological processes, root elongation and dentinogenesis, which are guaranteed by downgrowth of Hertwig's epithelial root sheath (HERS) and normal odontoblast differentiation. Ubiquitin-dependent protei...
FGF8 induces epithelial-mesenchymal transition and promotes metastasis in oral squamous cell carcinoma [0.03%]
FGF8诱导口腔鳞状细胞癌上皮间质转化并促进其转移
Yilong Hao,Yanxuan Xiao,Xiaoyu Liao et al.
Yilong Hao et al.
Oral squamous cell carcinoma (OSCC) is one of the most common cancers worldwide, and with 354 864 new cases each year. Cancer metastasis, recurrence, and drug resistance are the main causes to cripples and deaths of OSCC patients. As potent...
Removal of nonimpacted third molars alters the periodontal condition of their neighbors clinically, immunologically, and microbiologically [0.03%]
拔除未萌第三磨牙可使邻牙的临床、免疫及微生物状况发生改变
Yi Tian,Lijuan Sun,Honglei Qu et al.
Yi Tian et al.
Considering the adverse effects of nonimpacted third molars (N-M3s) on the periodontal health of adjacent second molars (M2s), the removal of N-M3s may be beneficial to the periodontal health of their neighbors. This study aimed to investig...
FACEts of mechanical regulation in the morphogenesis of craniofacial structures [0.03%]
颅面结构形态发生的机械调节机制
Wei Du,Arshia Bhojwani,Jimmy K Hu
Wei Du
During embryonic development, organs undergo distinct and programmed morphological changes as they develop into their functional forms. While genetics and biochemical signals are well recognized regulators of morphogenesis, mechanical force...
SOX2-dependent expression of dihydroorotate dehydrogenase regulates oral squamous cell carcinoma cell proliferation [0.03%]
SOX2依赖的二氢乳清酸脱氢酶表达调节口腔鳞状细胞癌增殖
Xuemei Qiu,Sheng Jiang,Yanxuan Xiao et al.
Xuemei Qiu et al.
Oral squamous cell carcinoma (OSCC) become a heavy burden of public health, with approximately 300 000 newly diagnosed cases and 145 000 deaths worldwide per year. Nucleotide metabolism fuel DNA replication and RNA synthesis, which is indis...
Novel MSX1 variants identified in families with nonsyndromic oligodontia [0.03%]
非综合征性多牙缺失家系中新的MSX1基因变异位点的鉴定
Jinglei Zheng,Miao Yu,Haochen Liu et al.
Jinglei Zheng et al.
The goal of this study was to identify MSX1 gene variants in multiple Chinese families with nonsyndromic oligodontia and analyse the functional influence of these variants. Whole-exome sequencing (WES) and Sanger sequencing were performed t...
Role of connexin 43 in odontoblastic differentiation and structural maintenance in pulp damage repair [0.03%]
缝隙蛋白43在牙髓损伤修复中的成odontoblast分化和结构维持中的作用研究
Jiaxin Yin,Jue Xu,Ran Cheng et al.
Jiaxin Yin et al.
Dental pulp can initiate its damage repair after an injury of the pulp-dentin complex by rearrangement of odontoblasts and formation of newly differentiated odontoblast-like cells. Connexin 43 (Cx43) is one of the gap junction proteins that...
Biological efficacy of perpendicular type-I collagen protruded from TiO2-nanotubes [0.03%]
垂直型I型胶原蛋白从TiO2纳米管中伸出的生物学效应
Chia-Yu Chen,David M Kim,Cliff Lee et al.
Chia-Yu Chen et al.
The aim of this study was to evaluate the biological efficacy of a unique perpendicular protrusion of type-I collagen (Col-I) from TiO2 nanotubes (NT-EPF surface). We hypothesized that the NT-EPF surface would play bifunctional roles in sti...
Parathyroid hormone increases alveolar bone homoeostasis during orthodontic tooth movement in rats with periodontitis via crosstalk between STAT3 and β-catenin [0.03%]
甲状旁腺激素通过STAT3和β-连环蛋白的相互作用增加牙周炎大鼠正畸牙齿移动期间的肺泡骨稳态
Cheng Zhang,Tiancheng Li,Chenchen Zhou et al.
Cheng Zhang et al.
Periodontitis patients are at risk of alveolar bone loss during orthodontic treatment. The aim of this study was to investigate whether intermittent parathyroid hormone (1-34) treatment (iPTH) could reduce alveolar bone loss during orthodon...