Dental impact of anti-fibroblast growth factor 23 therapy in X-linked hypophosphatemia [0.03%]
X连锁低磷血症患者抗成纤维细胞生长因子23治疗的牙科影响研究
Elis J Lira Dos Santos,Kenta Nakajima,Julien Po et al.
Elis J Lira Dos Santos et al.
Elevated fibroblast growth factor 23 (FGF23) in X-linked hypophosphatemia (XLH) results in rickets and phosphate wasting, manifesting by severe bone and dental abnormalities. Burosumab, a FGF23-neutralizing antibody, an alternative to conve...
Xiaoyu Li,Ou Jiang,Songlin Wang
Xiaoyu Li
Many tissues and organ systems have intrinsic regeneration capabilities that are largely driven and maintained by tissue-resident stem cell populations. In recent years, growing evidence has demonstrated that cellular metabolic homeostasis ...
Mesenchymal stem cell-derived apoptotic bodies alleviate alveolar bone destruction by regulating osteoclast differentiation and function [0.03%]
间充质干细胞凋亡体通过调节破骨细胞分化和功能缓解牙槽骨破坏
Xiaoyan Li,Yiyang Jiang,Xu Liu et al.
Xiaoyan Li et al.
Periodontitis is caused by overactive osteoclast activity that results in the loss of periodontal supporting tissue and mesenchymal stem cells (MSCs) are essential for periodontal regeneration. However, the hypoxic periodontal microenvironm...
Spatiotemporal cellular dynamics and molecular regulation of tooth root ontogeny [0.03%]
牙齿根发育过程中的时空细胞动力学及分子调控机制
Pengcheng Rao,Junjun Jing,Yi Fan et al.
Pengcheng Rao et al.
Tooth root development involves intricate spatiotemporal cellular dynamics and molecular regulation. The initiation of Hertwig's epithelial root sheath (HERS) induces odontoblast differentiation and the subsequent radicular dentin depositio...
Titanium particles in peri-implantitis: distribution, pathogenesis and prospects [0.03%]
种植体周围炎中的钛颗粒：分布、发病机制及前景展望
Long Chen,Zian Tong,Hongke Luo et al.
Long Chen et al.
Peri-implantitis is one of the most important biological complications in the field of oral implantology. Identifying the causative factors of peri-implant inflammation and osteolysis is crucial for the disease's prevention and treatment. T...
MLL1 inhibits the neurogenic potential of SCAPs by interacting with WDR5 and repressing HES1 [0.03%]
MLL1通过与WDR5相互作用并抑制HES1的表达来抑制SCAPs的神经分化潜能
Chen Zhang,Weilong Ye,Mengyao Zhao et al.
Chen Zhang et al.
Mesenchymal stem cell (MSC)-based therapy has emerged as a promising treatment for spinal cord injury (SCI), but improving the neurogenic potential of MSCs remains a challenge. Mixed lineage leukemia 1 (MLL1), an H3K4me3 methyltransferases,...
Sclerostin antibody improves alveolar bone quality in the Hyp mouse model of X-linked hypophosphatemia (XLH) [0.03%]
抗sclerostin抗体可改善Hyp小鼠模型中X连锁低磷血症（XLH）的牙槽骨质量
Kelsey A Carpenter,Delia O Alkhatib,Bryan A Dulion et al.
Kelsey A Carpenter et al.
X-linked hypophosphatemia (XLH) is a rare disease of elevated fibroblast growth factor 23 (FGF23) production that leads to hypophosphatemia and impaired mineralization of bone and teeth. The clinical manifestations of XLH include a high pre...
Double heterozygous pathogenic mutations in KIF3C and ZNF513 cause hereditary gingival fibromatosis [0.03%]
KIF3C和ZNF513的复合杂合致病突变导致遗传性牙龈纤维瘤病
Jianfan Chen,Xueqing Xu,Song Chen et al.
Jianfan Chen et al.
Hereditary gingival fibromatosis (HGF) is a rare inherited condition with fibromatoid hyperplasia of the gingival tissue that exhibits great genetic heterogeneity. Five distinct loci related to non-syndromic HGF have been identified; howeve...
Transcriptional profiling of dental sensory and proprioceptive trigeminal neurons using single-cell RNA sequencing [0.03%]
使用单细胞RNA测序对牙髓感觉和本体感受三叉神经元进行转录组分析
Pa Reum Lee,Jihoon Kim,Heather Lynn Rossi et al.
Pa Reum Lee et al.
Dental primary afferent (DPA) neurons and proprioceptive mesencephalic trigeminal nucleus (MTN) neurons, located in the trigeminal ganglion and the brainstem, respectively, are essential for controlling masticatory functions. Despite extens...
Yunhan Tan,Zhihan Wang,Mengtong Xu et al.
Yunhan Tan et al.
Oral squamous cell carcinoma (OSCC) develops on the mucosal epithelium of the oral cavity. It accounts for approximately 90% of oral malignancies and impairs appearance, pronunciation, swallowing, and flavor perception. In 2020, 377,713 OSC...