Spatiotemporal cellular dynamics and molecular regulation of tooth root ontogeny [0.03%]
牙齿根发育过程中的时空细胞动力学及分子调控机制
Pengcheng Rao,Junjun Jing,Yi Fan et al.
Pengcheng Rao et al.
Tooth root development involves intricate spatiotemporal cellular dynamics and molecular regulation. The initiation of Hertwig's epithelial root sheath (HERS) induces odontoblast differentiation and the subsequent radicular dentin depositio...
Titanium particles in peri-implantitis: distribution, pathogenesis and prospects [0.03%]
种植体周围炎中的钛颗粒：分布、发病机制及前景展望
Long Chen,Zian Tong,Hongke Luo et al.
Long Chen et al.
Peri-implantitis is one of the most important biological complications in the field of oral implantology. Identifying the causative factors of peri-implant inflammation and osteolysis is crucial for the disease's prevention and treatment. T...
MLL1 inhibits the neurogenic potential of SCAPs by interacting with WDR5 and repressing HES1 [0.03%]
MLL1通过与WDR5相互作用并抑制HES1的表达来抑制SCAPs的神经分化潜能
Chen Zhang,Weilong Ye,Mengyao Zhao et al.
Chen Zhang et al.
Mesenchymal stem cell (MSC)-based therapy has emerged as a promising treatment for spinal cord injury (SCI), but improving the neurogenic potential of MSCs remains a challenge. Mixed lineage leukemia 1 (MLL1), an H3K4me3 methyltransferases,...
Sclerostin antibody improves alveolar bone quality in the Hyp mouse model of X-linked hypophosphatemia (XLH) [0.03%]
抗sclerostin抗体可改善Hyp小鼠模型中X连锁低磷血症（XLH）的牙槽骨质量
Kelsey A Carpenter,Delia O Alkhatib,Bryan A Dulion et al.
Kelsey A Carpenter et al.
X-linked hypophosphatemia (XLH) is a rare disease of elevated fibroblast growth factor 23 (FGF23) production that leads to hypophosphatemia and impaired mineralization of bone and teeth. The clinical manifestations of XLH include a high pre...
Double heterozygous pathogenic mutations in KIF3C and ZNF513 cause hereditary gingival fibromatosis [0.03%]
KIF3C和ZNF513的复合杂合致病突变导致遗传性牙龈纤维瘤病
Jianfan Chen,Xueqing Xu,Song Chen et al.
Jianfan Chen et al.
Hereditary gingival fibromatosis (HGF) is a rare inherited condition with fibromatoid hyperplasia of the gingival tissue that exhibits great genetic heterogeneity. Five distinct loci related to non-syndromic HGF have been identified; howeve...
Transcriptional profiling of dental sensory and proprioceptive trigeminal neurons using single-cell RNA sequencing [0.03%]
使用单细胞RNA测序对牙髓感觉和本体感受三叉神经元进行转录组分析
Pa Reum Lee,Jihoon Kim,Heather Lynn Rossi et al.
Pa Reum Lee et al.
Dental primary afferent (DPA) neurons and proprioceptive mesencephalic trigeminal nucleus (MTN) neurons, located in the trigeminal ganglion and the brainstem, respectively, are essential for controlling masticatory functions. Despite extens...
Yunhan Tan,Zhihan Wang,Mengtong Xu et al.
Yunhan Tan et al.
Oral squamous cell carcinoma (OSCC) develops on the mucosal epithelium of the oral cavity. It accounts for approximately 90% of oral malignancies and impairs appearance, pronunciation, swallowing, and flavor perception. In 2020, 377,713 OSC...
Porphyromonas gingivalis, a periodontal pathogen, impairs post-infarcted myocardium by inhibiting autophagosome-lysosome fusion [0.03%]
牙龈卟啉单胞菌通过抑制自噬体-溶酶体融合损伤心肌梗死后的心肌功能
Yuka Shiheido-Watanabe,Yasuhiro Maejima,Shun Nakagama et al.
Yuka Shiheido-Watanabe et al.
While several previous studies have indicated the link between periodontal disease (PD) and myocardial infarction (MI), the underlying mechanisms remain unclear. Autophagy, a cellular quality control process that is activated in several dis...
Experts consensus on the procedure of dental operative microscope in endodontics and operative dentistry [0.03%]
显微镜在牙体牙髓病学操作中的专家共识
Bin Liu,Xuedong Zhou,Lin Yue et al.
Bin Liu et al.
The dental operative microscope has been widely employed in the field of dentistry, particularly in endodontics and operative dentistry, resulting in significant advancements in the effectiveness of root canal therapy, endodontic surgery, a...
Maxillary sinus floor augmentation: a review of current evidence on anatomical factors and a decision tree [0.03%]
上颌窦底提升的研究现状及决策树分析
Mingyue Lyu,Dingyi Xu,Xiaohan Zhang et al.
Mingyue Lyu et al.
Maxillary sinus floor augmentation using lateral window and crestal technique is considered as predictable methods to increase the residual bone height; however, this surgery is commonly complicated by Schneiderian membrane perforation, whi...