Tumor-intrinsic metabolic pathways essential for tumorigenesis and resistance to anti-PD1 in oncogenic Kras-driven lung adenocarcinoma [0.03%]
Karthik Vasan,Zachary R Chalmers,Hyewon Kong et al.
Karthik Vasan et al.
A shift in the cellular redox state redirects aspartate for export under glucose deprivation [0.03%]
细胞氧化还原状态的改变在葡萄糖剥夺时将天冬氨酸重新定向用于出口
Barbara Konrad,Gabriele Bluemel,Theresa Haitzmann et al.
Barbara Konrad et al.
Background: Glucose is an important fuel in cancer cells, however, its availability may be limited in solid tumors. Cell-autonomous, metabolic adaptations of cancer cells and non-malignant cells to glucose deprivation are...
Targeting FANCD2 to overcome enzalutamide resistance in prostate cancer [0.03%]
靶向FANCD2以克服前列腺癌中的恩杂鲁胺耐药性
Wenzhen Shi,Juliang Yang,Yue Xu et al.
Wenzhen Shi et al.
Targeting HIF-2α in colorectal cancer reveals a cholesterol biosynthesis-dependent ferroptotic vulnerability [0.03%]
靶向结直肠癌HIF-2α发现胆固醇生物合成依赖性铁死亡弱点
Prarthana J Dalal,Rashi Singhal,Boyan Hu et al.
Prarthana J Dalal et al.
Caspase-1/11 deficiency and cold exposure enhance the anti-tumor activity of brown adipose tissue secretome against breast cancer cells [0.03%]
caspase-1/11 缺失和冷暴露可增强棕色脂肪组织分泌组的抗肿瘤活性以对抗乳腺癌细胞
Luís Henrique Corrêa,Heloisa Antoniella Braz-de-Melo,Igor de Oliveira Santos et al.
Luís Henrique Corrêa et al.
Fos-induced osteosarcoma growth causes a cachexia-like phenotype in mice and correlates with high Fgf21 serum levels [0.03%]
Fos诱导的骨肉瘤生长导致小鼠出现类似恶病质的表型并伴有高水平的血清Fgf21
Julia Luther,Armelle Carreau,Christina Baldauf et al.
Julia Luther et al.
The FGL1-LAG-3 axis attenuates melanoma-induced cachexia in mice [0.03%]
FGL1-LAG-3轴通过减轻小鼠黑色素瘤消耗性缓症来抑制黑色素瘤生长
Weitao Liu,Lining Wang,Shumei Jin et al.
Weitao Liu et al.
The role of deoxycholic acid in macrophage polarization and remodeling of the tumor microenvironment during colorectal adenoma-carcinoma transition [0.03%]
脱氧胆酸在结肠腺瘤-癌转化过程中介导巨噬细胞极化及肿瘤微环境重塑中的作用研究
Yujing Liu,Jie Yin,Lu Lu et al.
Yujing Liu et al.
During the progression from colorectal adenoma to colorectal cancer (CRC), the inflammatory state of the tumor microenvironment (TME) evolves in parallel with the epithelial‒mesenchymal transition (EMT) process. Among the key players, macr...
Sustained reductions in valine and isoleucine mediate anti-cancer pharmacological effects of inhibiting amino acid transporter LAT1 in cancer cells [0.03%]
缬氨酸和异亮氨酸的持续降低介导了抑制癌细胞氨基酸转运蛋白LAT1的抗癌药理作用
Kou Nishikubo,Ryuichi Ohgaki,Hiroki Okanishi et al.
Kou Nishikubo et al.
Background: L-type amino acid transporter 1 (LAT1; SLC7A5), which preferentially transports large neutral amino acids (LNAAs), is highly upregulated in various cancers and represents a promising therapeutic target. The fi...
Cdk5 regulates glutamine metabolism in colorectal cancer via the EZH2-GLS1 axis [0.03%]
CDK5通过EZH2-GLS1轴调控结直肠癌的谷氨酰胺代谢
Qilong Wu,Xiaotong Zhu,Xinxin Wan et al.
Qilong Wu et al.
Colorectal cancer (CRC) is a globally prevalent malignancy that poses a substantial threat to human health. Despite advancements in prevention, diagnosis, and treatment, CRC remains a formidable clinical challenge due to the incomplete eluc...