Caloric restriction enhances radiosensitivity of colorectal tumors through the cGAS-STING pathway activation [0.03%]
卡路里限制通过激活cGAS-STING信号通路增强结直肠肿瘤放射敏感性
Li-Li Zhang,Li-Qiang Qin,Li Ding et al.
Li-Li Zhang et al.
Although radiotherapy is an important clinical option for colorectal cancer, its efficacy is limited by intrinsic tumor radioresistance and radiation-induced toxicity in surrounding normal tissues. This study investigated the radiosensitizi...
VAV2 drives glycolytic reprogramming in esophageal squamous cell carcinoma via EIF3F-mediated MTA1 deubiquitination [0.03%]
VAV2通过EIF3F介导的MTA1去泛素化驱动食管鳞癌糖酵解重构
Weiling Liu,Yangyang Hou,Bo Wang et al.
Weiling Liu et al.
Despite therapeutic advances, esophageal squamous cell carcinoma (ESCC) remains lethal due to metabolic adaptation via aerobic glycolysis. Here we report that VAV2 functions as an oncoprotein promoting this metabolic switch in ESCC. VAV2 ov...
Fasting-mimicking diet counteracts gut microbial dysbiosis in experimental lynch syndrome [0.03%]
模拟禁食的饮食可改善实验性林奇综合征患者的肠道微生物群失调现象
Lorena Garcia-Castillo,Giulio Ferrero,Olga Blaževitš et al.
Lorena Garcia-Castillo et al.
The development of colorectal cancer (CRC) is largely influenced by hereditary factors, with up to one-third of cases linked to genetic predisposition. In parallel, environmental factors such as diet and intestinal microbiota play a signifi...
CRISPR screen identifies autophagy inhibition (GNS561) as a PARP inhibitor (AZD5305) combination strategy in small cell lung cancer [0.03%]
基于CRISPR的筛选发现自噬抑制(GNS561)可作为PARP抑制剂(AZD5305)在小细胞肺癌中联合用药的新策略
Tony Yu,Ranya Barayan,Lifang Song et al.
Tony Yu et al.
Background: Small cell lung cancer (SCLC) is a deadly cancer with few treatment options and poor prognosis, creating a dire need for improving therapies. Poly (ADP-ribose) polymerase inhibitors (PARPi) have been tested as...
Identification of alpha1-oleate as a potent regulator of adipokine-dependent metabolism, in bladder cancer tissue [0.03%]
鉴定α1-油酸作为强力脂肪细胞依赖性代谢调节剂在膀胱癌组织中的作用
Farhan Haq,Siddharth Chinchankar,Ines Ambite et al.
Farhan Haq et al.
Background: Metabolic dysfunctions are associated with increased cancer morbidity and rapid tumor progression. The alpha1-oleate complex has been used successfully to treat bladder cancer in a placebo-controlled Phase II ...
DLL1-mediated ferroptosis resistance via the Notch-Nrf2/GPX4 axis drives cisplatin resistance in ovarian cancer [0.03%]
NOTCH-NRF2/GPX4轴介导的DLL1促进卵巢癌顺铂耐药性通过抑制铁死亡发生
Dan Ye,Gaoting Huang,Xingcheng Yan et al.
Dan Ye et al.
Background: Ovarian cancer (OV) is a leading cause of cancer-related mortality, with cisplatin resistance being a major clinical challenge. This study investigates the role of the Notch ligand DLL1 in mediating ferroptosi...
Fine particulate matter and tobacco product exposure exacerbates metabolic syndrome-related colon cancer via regulating oxidative stress and tumor-associated macrophage interactions [0.03%]
细颗粒物和烟草产品暴露通过调节代谢综合征相关结直肠癌的氧化应激和肿瘤相关巨噬细胞相互作用来加重代谢综合征相关结直肠癌
Shenghua Zhang,Dongfang Meng,Haibo Zhang et al.
Shenghua Zhang et al.
Background: The incidence of colorectal cancer (CRC) is closely associated with prolonged exposure to fine particulate matter (PM 2.5) and tobacco carcinogens, 4-methylnitrosamino-l-3-pyridyl-butanone (NNK). However, due ...
A method utilizing chemical carcinogens and a Western diet to reliably induce advanced hepatocellular carcinoma in male and female mice [0.03%]
一种利用化学致癌物和西方饮食可靠诱导小鼠男女性肝细胞癌的方法
Melina C Mancini,Elise R Adams,David H Burk et al.
Melina C Mancini et al.
Background: A combination of chemical carcinogens and Western diet have been used to induce hepatocellular carcinoma (HCC) in mice, but these models show low incidence of HCC in female mice, while mice that do develop HCC...
CYP8B1 suppressed by Ras/ERK leads to cholesterol accumulation and bile acids reduction and facilitates hepatic tumorigenesis [0.03%]
Ras/ERK抑制的CYP8B1导致胆固醇积累和胆汁酸减少并促进肝细胞瘤发生
Juan Li,Huiling Li,Lili Dong et al.
Juan Li et al.
Background: Cholesterol (CHO)/bile acids (BAs) homeostasis is critically involved in hepatocellular carcinoma (HCC), yet the underlying mechanisms and the specific regulatory role of CYP8B1-a key enzyme maintaining this b...
Gut microbiota-derived indole-3-propionic acid promotes lymph node metastasis in gastric cancer via the aryl-hydrocarbon receptor signaling pathway [0.03%]
胃癌中肠道微生物来源的没食子酸通过芳烃受体信号通路促进淋巴结转移
Mingfei Wang,Yan Wang,Mingshuai Bai et al.
Mingfei Wang et al.
Background: Gut microbiota (GM) regulates the tumor microenvironment through microbial metabolites. Indole 3-propionic acid (3-IPA) is one such metabolite that regulates gastrointestinal barrier function. In this study, w...