BCAT1 inhibits glutamine-dependent Akt/mTOR signaling and nucleotide synthesis by initiating BTRC-mediated degradation of SLC3A2 in pancreatic adenocarcinoma [0.03%]
Huimin Huang,Xinheng Liu,Xi Chen et al.
Huimin Huang et al.
Purpose: Pancreatic adenocarcinoma (PAAD) is characterized by profound metabolic reprogramming, including altered branched-chain amino acid (BCAA) metabolism. While the tumor-promoting role of branched-chain aminotransfer...
Oncometabolite fumarate impairs ATR-CHK1 signaling by succinating RPA1 in fumarate hydratase-deficient renal cell carcinoma cells [0.03%]
富马酸盐通过使RPA1天冬氨酸琥珀化损伤ATR-CHK1信号通路，在FH缺陷型肾癌细胞中发挥致癌代谢物的作用
Nian Liu,Changxian Shen,Tingting Zhou et al.
Nian Liu et al.
SENP1 drives de novo cholesterogenesis via disrupting SUMOylation-mediated SREBP2-FBXW7 interaction [0.03%]
SENP1通过干扰SUMO化介导的SREBP2-FBXW7相互作用来驱动胆固醇从头合成
Chun Yang,Qingbo Wang,Bangmin Han et al.
Chun Yang et al.
In vivo characterization of the redox balance in IDH-wildtype glioblastomas: a J-difference edited MEGA-sLASER MRS study at 3T [0.03%]
IDH野生型胶质母细胞瘤体内红氧平衡特征的J差异编辑MEGA-sLASER MRS研究（3T）
Seyma Alcicek,Andrei Manzhurtsev,Dennis C Thomas et al.
Seyma Alcicek et al.
Background: Isocitrate dehydrogenase-wildtype glioblastoma (IDHwtGB) is the most common primary malignant brain tumor in adults, with a universally poor prognosis. For survival and growth under conditions of the tumor mic...
PFKFB4 promotes M2 polarization of tumor-associated macrophages through aerobic glycolysis-mediated modification of histone H3K18 lactylation in hepatocellular carcinoma [0.03%]
PFKFB4通过有氧糖酵解介导的组蛋白H3K18乳酸化修饰促进肝细胞癌相关巨噬细胞M2极化
Chao Gan,Dan Wu,Yue Yuan et al.
Chao Gan et al.
Combining ferroptosis inducers with gemcitabine to enhance treatment efficacy in pancreatic cancer [0.03%]
联合使用促铁死亡诱导剂和吉西他滨以增强对胰腺癌的治疗效果
Hanyun Zhang,Wenjie Lu
Hanyun Zhang
Background: Gemcitabine (GEM) is a standard chemotherapy for pancreatic cancer, but resistance limits its clinical benefit. The role of SRRM1, a splicing regulator, in GEM resistance remains unclear. ...
POU2F1 drives cholesterol biosynthesis and lipid remodeling through the DHCR24/ELOVL2 axis in endometrial cancer [0.03%]
POU2F1通过DHCR24/ELOVL2轴驱动胆固醇生物合成和脂质重塑在子宫内膜癌中的作用
Zi-Hui Zhang,Fei-Fei Yuan,Lian Yang et al.
Zi-Hui Zhang et al.
Tumor cell death by ferroptosis contributes to an immunosuppressive tumor microenvironment in syngeneic murine models of cancer [0.03%]
肿瘤细胞通过铁死亡在同基因小鼠癌症模型中产生免疫抑制性肿瘤微环境
Nneka E Mbah,Damien Sutton,Hanna S Hong et al.
Nneka E Mbah et al.
Pancreatic ductal adenocarcinoma (PDAC) is characterized by profound metabolic rewiring and a strongly immunosuppressive tumor microenvironment, both of which contribute to poor therapeutic responses. Immunogenic cell death (ICD) represents...
Measurement of mitochondria amount and clearance using flow cytometry: effect of mitophagy inhibitors in leukemia cells [0.03%]
流式细胞术测定线粒体含量和清除量：线粒体自噬抑制剂对白血病细胞的影响
Tereza Kořánová,Dana Grebeňová,Kateřina Kuželová
Tereza Kořánová
PER2 knockdown drives immunotherapy resistance in gastric cancer via metabolic reprogramming of myeloid-derived suppressor cells [0.03%]
PER2敲低通过重新编程胃癌中髓系衍生抑制细胞的代谢驱动免疫治疗抵抗性
Shenggang Zhan,Shixi Lu,Feng Xiong et al.
Shenggang Zhan et al.