Autophagic flux blockade under hypocapnia reveals CO₂-sensitive regulation of autophagy-lysosome homeostasis [0.03%]
低二氧化碳条件下自噬溶酶体稳态的自噬流阻断及二氧化碳敏感性调节机制研究
Naghmana Ashraf,Zhen Sun,Jeanine L Van Nostrand
Naghmana Ashraf
Hypocapnia, a reduction in partial pressure of carbon dioxide (CO₂), commonly occurs in clinical contexts such as mechanical ventilation, panic disorder, and brain injury, yet its impact on cellular homeostasis remains poorly understood. G...
SPSP-1 is a sperm protein required for C. elegans hermaphrodite sperm production and embryogenesis [0.03%]
SPSP-1是C-elegans雌雄同体精子生成和胚胎发育所需的一种精子蛋白
Darline Murat,Margaret Nagorski,Ji Kent Kwah et al.
Darline Murat et al.
Development requires the fusion of gametes each with a haploid complement of DNA and the necessary components (RNA, proteins, organelles) needed for early cellular processes and divisions. The C. elegans paternal-effect embryonic lethal gen...
Retention and tissue-specific expression of uncoupling protein homoeologs in Xenopus laevis [0.03%]
非洲爪蟾解偶联蛋白同位基因的保留及其组织特异性表达
Erik Rollwitz,Martin Jastroch
Erik Rollwitz
Mitochondrial uncoupling proteins (UCPs) play central roles in vertebrate energy metabolism, with UCP1 specializing as a thermogenic effector in placental mammals. Comparative genomics demonstrated that UCP1, UCP2, and UCP3 originated prior...
Activation-induced cytidine deaminase promotes DNA demethylation and expression of the Ninjurin-2 gene [0.03%]
激活诱导胞苷脱氨酶促进Ninjurin-2基因的去甲基化和表达
Toshiyuki Okada,Yusuke Toyoda,Shigeaki Saitoh
Toshiyuki Okada
Activation-induced cytidine deaminase (AID) is expressed in germinal center B cells and contributes to somatic hypermutation and isotype switching of immunoglobulins. AID is also reportedly expressed in colonic epithelial cells (CECs) durin...
Investigating the impact of poly(beta amino) ester-mediated FOXJ1 mRNA delivery on differentiation of primary human bronchial epithelial cells [0.03%]
聚(β-氨基酯)介导FOXJ1 mRNA递送对原代人支气管上皮细胞分化的影响研究
Rafaela Konstantinidi,Mira Subramanian,Laura Yates et al.
Rafaela Konstantinidi et al.
Primary human basal bronchial epithelial cells (HBECs) are an important population of progenitor cells capable of self-renewal and differentiation to maintain airway homeostasis. In air-liquid interface (ALI) culture, HBECs undergo mucocili...
The Zinc contraceptive effect: Targets, timing, and quantitative thresholds [0.03%]
锌的避孕作用：目标、时机和定量阈值
Kirsten Shankie-Williams,Margot Day,Samson Dowland
Kirsten Shankie-Williams
There is a critical need for novel non-hormonal contraceptives. Zinc-based intrauterine devices (IUDs) demonstrate 100% efficacy in rats, yet the mechanism remains unclear. We investigated whether zinc targets sperm, embryos, or the endomet...
Histone and non-histone protein acetylation in a tail regeneration model (Ambystoma mexicanum) [0.03%]
墨西哥钝头螈尾部再生模型中的组蛋白和非组蛋白蛋白质乙酰化作用研究
Nataliya Timoshevskaya,Raissa F Cecil,James Schwartz et al.
Nataliya Timoshevskaya et al.
Histone deacetylase inhibitors (HDACi) potently inhibit appendage regeneration, but how HDACi alter protein acetylation is relatively unexplored. Using genomic, transcriptomic, and proteomic approaches, we report HDACi-mediated changes in g...
Perspectives from the 2024 School on Neuropharmacology Research and Drug Development in Harare, Zimbabwe: insights from participants [0.03%]
2024年津巴布韦哈拉雷神经药理学研究与药物开发学校观点：参与者见解
John Senanu,Bertrand Yuwong Wanyu,Jessica Burns et al.
John Senanu et al.
Sub-Saharan Africa is experiencing a rising burden of neurological and mental disorders. The International Brain Research Organization (IBRO)-funded 2nd School on Neuropharmacology Research and Drug Development (NRDD) was held in Harare, Zi...
Differential response variability of black-capped chickadees to wingbeat sounds and vocalizations [0.03%]
黑顶 Chickadee 对翅膀拍打声和鸣叫声的反应差异性分析
Prateek K Sahu,Kailyn Nottebrock,Julian Ratch et al.
Prateek K Sahu et al.
Prey species use various cues (visual, acoustic, olfactory) to detect approaching predators. Among these, visual cues are generally considered reliable, providing immediate and accurate information about potential dangers. While acoustic cu...
Post-ejaculatory thermal sensitivity of sperm performance in the high-altitude lizard Phymaturus extrilidus [0.03%]
高海拔蜥蜴Phymaturus extrilidus精子性能的排精后热敏性
Rodrigo Gómez Alés,Guadalupe López Juri,Franco Valdez Ovallez et al.
Rodrigo Gómez Alés et al.
Rising environmental temperatures may differentially affect physiological processes in ectotherms, with sperm function representing a potentially critical but understudied vulnerability. We experimentally evaluated post-ejaculatory thermal ...