Retrograde signaling is required for Slm35-mediated negative regulation of mitophagy in yeast [0.03%]
Slm35介导的酿酒酵母线粒体自噬负调控需要逆向信号通路
Hilario Ruelas-Ramírez,Ariann E Mendoza-Martínez,P Abril Medina-Flores et al.
Hilario Ruelas-Ramírez et al.
Mitophagy is essential for mitochondrial quality control, selectively removing damaged or superfluous mitochondria to maintain cellular health and metabolic homeostasis. While positive regulators of mitophagy are relatively well characteriz...
Methylation-based signature to distinguish indolent and aggressive prostate cancer [0.03%]
基于甲基化的前列腺癌惰性和侵袭性表型的判别标志物研究
Muheng Liao,Jace Webster,Amy Ly et al.
Muheng Liao et al.
Prostate cancer management faces significant challenges in distinguishing indolent from aggressive disease, particularly since most patients are intermediate-risk and therefore hinders the ability to recommend standardized treatment recomme...
Karima El Mahboubi,Facundo Romani
Karima El Mahboubi
The Genetics Society Non-Seed Plant meeting brought together researchers embracing the diversity of plants and using emerging and established model systems covering hornworts, mosses, liverworts, lycophytes and ferns. This growing community...
The placental effects of trisomy for human chromosome 21 orthologs in four mouse models of Down syndrome [0.03%]
四個唐氏綜合征小鼠模型中人 chromosome 21 同源物三體對胎盤的作用
Taisuke Sato,Laura L Baxter,April D Adams et al.
Taisuke Sato et al.
Down syndrome (DS) is caused by trisomy for human chromosome 21 (Hsa21) and is associated with atypical neurodevelopment that begins prenatally. The developing human fetus receives nutritional support and gas exchange from the placenta, and...
Transcriptomics informed discovery of developmentally essential transcription factors [0.03%]
转录组信息引导发现对发育至关重要的转录因子
Gillian Forbes,Pauline Schaap
Gillian Forbes
Transcription factors (TFs) regulate cell differentiation in multicellular organisms and were mostly identified by forward genetics in model organisms. However, genomes contain several-fold more TFs without known roles. To classify these or...
Dynamic expression and differential requirement of the myocyte fusogen Myomixer during distinct myogenic episodes in the zebrafish [0.03%]
动态表达的肌细胞融合蛋白Myomixer在斑马鱼不同类型的肌肉形成过程中的差异需求性研究
Sunandan Dhar,Serena Thomas,Hui Li Yeo et al.
Sunandan Dhar et al.
Skeletal muscle formation involves the fusion of myocytes into precisely aligned, multinucleated myofibres. These fibres continue to grow through reiterative rounds of myocyte fusion, incorporating new myonuclei and supporting muscle growth...
The short isoform of Tango1 is dispensable for zebrafish survival but is required for skeletal patterning and integrity [0.03%]
短型Tango1蛋白对于斑马鱼存活是不需要的，但其对骨骼构图和完整性有要求
Elizabeth A Lawrence,Maria Esther Prada-Sanchez,Qiao Tong et al.
Elizabeth A Lawrence et al.
Collagen is the most abundant protein in the human body, providing structural stability to connective tissues. It organises and interacts with other proteins to form a complex extracellular matrix (ECM), with loss of collagen in the ECM see...
Sydney Roman,Nathalie Oulhen,Gerardo Reyes et al.
Sydney Roman et al.
The extracellular matrix (ECM) is a critical component of embryonic development, providing both structural support and a dynamic signaling environment for cell migration, adhesion, and tissue organization. Collagen, the most abundant protei...
Fiona M Mensching,Niusha Banoukh,M Kathryn Iovine
Fiona M Mensching
Cohesinopathies and ciliopathies are congenital disorders affecting overlapping body systems. The extent to which these syndromes may be linked remains largely untested. Recently, reduced expression of a cohesin core subunit, Smc3, was foun...
Nuclear enlargement induced by overexpression of nuclear export signal is associated with abnormal nuclear division in Schizosaccharomyces pombe [0.03%]
核输出信号过量表达诱导的核增大与裂殖酵母中的异常核分裂有关
Takahiro Fujimoto,Suzu Watanabe,Yuko Imamura et al.
Takahiro Fujimoto et al.
The size of the nucleus is tightly coordinated with cell size across eukaryotes, yet the physiological significance of maintaining proper nuclear dimensions remains poorly understood. Here, we investigate how nuclear size dysregulation resu...