Microtubules in the coenocyte Phytophthora function in nuclear positioning and sustaining tip growth [0.03%]
卵菌类质配体中微管素参与细胞核定位和顶端生长维持
Michiel Kasteel,Kiki Kots,Johan van den Hoogen et al.
Michiel Kasteel et al.
The microtubule cytoskeleton consists of dynamic intracellular filaments and is involved in numerous processes, ranging from nuclear division to intracellular transport. Some of these microtubule-mediated processes are conserved in all euka...
Cooperation, privatization and cheating in microbial exoenzyme synthesis: theoretical analysis in view of biotechnological applications [0.03%]
合作、私有化及欺骗在微生物胞外酶合成中的作用——从生物技术应用角度进行的理论分析
Tanvir Hassan,Shalu Dwivedi,Stefan Schuster et al.
Tanvir Hassan et al.
This study presents a mathematical framework for investigating the dynamics of coexistence and competition among heterotrophic microbes across different time scales. Focusing on metabolic interactions, we examine how three strategies, publi...
Michaela E Cooke,Rachel A Ross
Michaela E Cooke
Feeding behaviour is not solely governed by metabolic need, but emerges from the integration of internal state, sensory input, competing motivational demands and prior experience. In this review, we synthesize current understanding of the n...
Removing the noise: endotoxin-free α-synuclein for accurate in vitro screening of fibrillation modulators [0.03%]
去除噪音：无内毒素α-突触核蛋白的体外聚集聚合物调节剂筛选法
Julia Flor,Daniel Izecksohn,Daniel Grasseschi et al.
Julia Flor et al.
The presence of lipopolysaccharide (LPS) contaminant from the vector expression bacteria Escherichia coli was described as a factor responsible for accelerating the in vitro fibrillation of recombinant α-synuclein (αS), a key protein invo...
Domain innovation and deeply conserved intrinsic disorders in eukaryotic argonaute [0.03%]
真核Argonaute的领域创新和深具保守性的内在无序区域
Diego Forni,Rachele Cagliani,Alessandra Mozzi et al.
Diego Forni et al.
Argonaute (Ago) proteins are distributed across all domains of life and play central roles in the defence against mobile genetic elements. We performed extensive searches of Ago proteins across eukaryotes. We revealed wide variability in th...
Deep learning in tumour genomics: from multi-omics integration to precision oncology [0.03%]
深度学习在肿瘤基因组学中的应用：从多组学整合到精准肿瘤学
Zeya Zhou,Zijin Li,Sinuo Wang et al.
Zeya Zhou et al.
Cancer remains a leading cause of death globally, with nearly 10 million deaths in 2020. Advances in genomic technologies have revolutionized cancer research, shifting focus towards precision medicine based on comprehensive tumour genomic p...
Understanding GnRH: local systems, signalling mechanisms and implications in female health [0.03%]
理解GnRH：局部系统、信号传导机制及其在女性健康中的影响
Lily Tosh,Kirsty Tinto,Margaret Cunningham et al.
Lily Tosh et al.
Gonadotropin-releasing hormone (GnRH) is a peptide hormone forming a central component of the hypothalamic-pituitary-gonadal axis and is critical for controlling reproductive functions. Dysregulated GnRH is implicated in many steroid hormon...
The evolution and functional significance of neuropeptide cocktails: insights from SALMFamides in asteroid echinoderms [0.03%]
神经肽鸡尾酒的演化及功能意义——海星纲棘皮动物SALMFamide的研究启示
Nayeli Escudero Castelán,Maurice R Elphick
Nayeli Escudero Castelán
Neuropeptides derived from larger precursor proteins are neuronal signalling molecules that regulate physiological processes and behaviour. Some precursors, particularly in invertebrates, give rise to 'cocktails' of structurally related neu...
Structural basis of Drosophila insulin receptor activation by DILP2 hormone [0.03%]
DILP2激素激活果蝇胰岛素受体的结构基础
Talha Shafi,Olga V Moroz,Huw T Jenkins et al.
Talha Shafi et al.
Insulin-related hormones regulate key life processes in the animal kingdom, from metabolism to growth, lifespan and ageing, through an evolutionarily conserved insulin and insulin-like hormones signalling axis (IIS). In humans, the IIS axis...
Parental rearing shapes brain functional networks and socio-sexual behaviours in the prairie vole [0.03%]
父母抚育方式塑造草原田鼠的大脑功能网络及社会性行为
M Fernanda López-Gutiérrez,Zeus Gracia-Tabuenca,Juan J Ortiz-Retana et al.
M Fernanda López-Gutiérrez et al.
Animal models with natural variation in family structure, like the prairie vole (Microtus ochrogaster), offer valuable insight into how parental care shapes offspring behaviour. While prior studies have linked early care to long-term behavi...