A bivalent protein targeting glycans and HR1 domain in spike protein potently inhibited infection of SARS-CoV-2 and other human coronaviruses [0.03%]
一种能够同时靶向刺突蛋白HR1结构域和糖基的双价蛋白高效抑制SARS-CoV-2及其他人类冠状病毒感染
Yanxing Cai,Wei Xu,Jiayi Tang et al.
Yanxing Cai et al.
Background: Our previous studies have shown that combining the antiviral lectin GRFT and the pan-CoV fusion inhibitory peptide EK1 results in highly potent inhibitory activity against SARS-CoV-2 infection. In this study, ...
PIAS1 potentiates the anti-EBV activity of SAMHD1 through SUMOylation [0.03%]
PIAS1通过SUMO化增强SAMHD1的抗EBV活性
Farjana Saiada,Kun Zhang,Renfeng Li
Farjana Saiada
Background: Sterile alpha motif and HD domain 1 (SAMHD1) is a deoxynucleotide triphosphohydrolase (dNTPase) that restricts the infection of a variety of RNA and DNA viruses, including herpesviruses. The anti-viral functio...
Metabolomic and transcriptomic profiling of adult mice and larval zebrafish leptin mutants reveal a common pattern of changes in metabolites and signaling pathways [0.03%]
对成人小鼠和斑马鱼幼虫瘦素突变体的代谢组学和转录组学分析揭示了代谢物和信号通路变化的共同模式
Yi Ding,Mariëlle C Haks,Gabriel Forn-Cuní et al.
Yi Ding et al.
Background: Leptin plays a critical role in the regulation of metabolic homeostasis. However, the molecular mechanism and cross talks between leptin and metabolic pathways leading to metabolic homeostasis across different...
Single-cell transcriptomic analysis of endometriosis provides insights into fibroblast fates and immune cell heterogeneity [0.03%]
单细胞转录组分析揭示子宫内膜异位症成纤维细胞的命运和免疫细胞的异质性
Junyan Ma,Liqi Zhang,Hong Zhan et al.
Junyan Ma et al.
Background: Endometriosis is an oestrogen-dependent disease with an unclear aetiology and pathogenesis affecting 6-10% of the global female population, predominantly those of reproductive age. Herein, we profile the trans...
Apatinib induces endoplasmic reticulum stress-mediated apoptosis and autophagy and potentiates cell sensitivity to paclitaxel via the IRE-1α-AKT-mTOR pathway in esophageal squamous cell carcinoma [0.03%]
阿帕替尼通过IRE-1α-AKT-mTOR信号通路诱导食管鳞状细胞癌内质网应激介导的凋亡和自噬并增敏紫杉醇的作用
Yu-Ming Wang,Xin Xu,Jian Tang et al.
Yu-Ming Wang et al.
Background: Apatinib, a novel vascular endothelial growth factor receptor-2 (VEGFR-2) tyrosine kinase inhibitor, has been approved for the treatment of metastatic gastric cancer and other tumors. Apatinib exerts antiproli...
Elevated NTCP expression by an iPSC-derived human hepatocyte maintenance medium enhances HBV infection in NTCP-reconstituted HepG2 cells [0.03%]
一种iPSC来源的人肝细胞维持培养基通过提高NTCP表达增强HBV在NTCP重建的HepG2细胞中的感染性
Xinlei Li,Zhaohui Xu,Bidisha Mitra et al.
Xinlei Li et al.
Background: The sodium taurocholate cotransporting polypeptide (NTCP) is a functional receptor for hepatitis B virus (HBV). NTCP-reconstituted human hepatoma cells support HBV infection, but the infection is suboptimal an...
Applications and analytical tools of cell communication based on ligand-receptor interactions at single cell level [0.03%]
基于单细胞水平配体-受体相互作用的细胞通讯的应用和分析工具
Fen Ma,Siwei Zhang,Lianhao Song et al.
Fen Ma et al.
Background: Cellular communication is an essential feature of multicellular organisms. Binding of ligands to their homologous receptors, which activate specific cell signaling pathways, is a basic type of cellular communi...
Tumor protein D52 is upregulated in oral squamous carcinoma cells under hypoxia in a hypoxia-inducible-factor-independent manner and is involved in cell death resistance [0.03%]
肿瘤蛋白D52在低氧诱导因子独立的口腔鳞状细胞癌中上调并参与抗细胞死亡
Yuzo Abe,Yoshiki Mukudai,Mai Kurihara et al.
Yuzo Abe et al.
Background: Tumor protein D52 (TPD52) reportedly plays an important role in the proliferation and metastasis of various cancer cells, including oral squamous cell carcinoma (OSCC) cells, and is expressed strongly at the c...
Discovery of chemerin as the new chemoattractant of human mesenchymal stem cells [0.03%]
人源间充质干细胞新趋化因子chemerin的发现
Irene Kim,Hyomin Park,Injoo Hwang et al.
Irene Kim et al.
Background: The homing capacity of human mesenchymal stem cells (hMSCs) to the injured sites enables systemic administration of hMSCs in clinical practice. In reality, only a small proportion of MSCs are detected in the t...
Multiple responses contribute to the enhanced drought tolerance of the autotetraploid Ziziphus jujuba Mill. var. spinosa [0.03%]
多倍体枣对干旱胁迫的耐受性增强是多种机制协同作用的结果
Meng Li,Chenxing Zhang,Lu Hou et al.
Meng Li et al.
Background: Polyploid plants often exhibit enhanced stress tolerance. The underlying physiological and molecular bases of such mechanisms remain elusive. Here, we characterized the drought tolerance of autotetraploid sour...