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PIAS1 potentiates the anti-EBV activity of SAMHD1 through SUMOylation

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Background: Sterile alpha motif and HD domain 1 (SAMHD1) is a deoxynucleotide triphosphohydrolase (dNTPase) that restricts the infection of a variety of RNA and DNA viruses, including herpesviruses. The anti-viral function of SAM... ...