ROCK2 inhibition suppresses cytotoxic T lymphocyte-mediated platelet destruction in primary immune thrombocytopenia [0.03%]
ROCK2抑制可减弱原发性免疫性血小板减少症中细胞毒性T淋巴细胞介导的血小板破坏作用
Juanjuan Song,Bingjie Ding,Qian Liu et al.
Juanjuan Song et al.
Cytotoxic T lymphocyte (CTL)-mediated platelet destruction represents an important pathogenic mechanism in primary immune thrombocytopenia (ITP) patients. Rho-associated coiled-coil kinase 2 (ROCK2) is an emerging regulator of immune balanc...
Finding functional gaps: integrative analysis of VPAC1- and VPAC2-mediated signalling pathways in human lymphocytes [0.03%]
寻找功能空隙：人淋巴细胞中VPAC1和VPAC2介导的信号转导通路的整合分析
Alicia Cabrera-Martín,Paula Arribas-Castaño,David Castro-Vázquez et al.
Alicia Cabrera-Martín et al.
Background: Vasoactive Intestinal Peptide (VIP) is a pleiotropic neuropeptide regulating diverse cellular and physiological processes. Its functions are primarily mediated through two G protein-coupled receptors, VPAC1 an...
Correction: Regulation of oncogenic C-terminal truncated p53β protein isoform expression by SRSF3-UPF1 splicing and surveillance axis [0.03%]
correction: SRSF3-upf1拼接和监视轴调控致癌型p53β蛋白剪接异构体表达
Jiwon Jeong,Dawon Hong,Tae Young Park et al.
Jiwon Jeong et al.
Published Erratum
Cell & bioscience. 2026 Jul 13;16(1):77. DOI:10.1186/s13578-026-01604-0 2026
Macrophage Notch1 drives hepatocyte ferroptosis via the exosomal miR-142a-3p/TIPE2 axis to promote MASH progression [0.03%]
巨噬细胞Notch1通过外泌体miR-142a-3p/TIPE2轴诱导肝细胞铁死亡促进MASH进展
Xiaoyu Dong,Mengya Zhang,Xiaoxing Huang et al.
Xiaoyu Dong et al.
Metabolic dysfunction-associated steatohepatitis (MASH) is a serious chronic liver disease, in which ferroptosis has been identified as a crucial triggering event. However, the precise mechanisms of ferroptosis activation in MASH have not b...
The diversity of STING in regulating immune cell function and its role in liver diseases: from bench to bedside [0.03%]
STING在调控免疫细胞功能及肝脏疾病中的多样性作用：从实验台到病床
Jing Lin,Yongle Liu,Yu Chen et al.
Jing Lin et al.
Background: The cyclic guanosine monophosphate-adenylate synthase (cGAS)-stimulator of interferon genes (STING) pathway is a critical innate immune signaling pathway that recognizes and transmits cytoplasmic DNA signals, ...
Genome-wide association and polygenic risk score analyses of MASLD-related hepatic steatosis severity in a Taiwanese Han population [0.03%]
台湾汉族人群MASLD相关肝脂肪变程度的全基因组关联和多基因风险评分分析
Ting-Yuan Liu,Jai-Sing Yang,Yu-Chia Chen et al.
Ting-Yuan Liu et al.
Background: Hepatic steatosis is a highly prevalent metabolic condition and a major contributor to chronic liver disease, particularly in Asian populations. This study was conducted to identify genetic variants associated...
Core binding factor β preserves early chondrogenic identity and prevents hypertrophic transition in cartilage organoids formation [0.03%]
核心结合因子β保留早期软骨细胞身份并防止软骨器官形成过程中的肥大转化
Xiangguo Che,Xian Jin,Dong-Kyo Lee et al.
Xiangguo Che et al.
Human-induced pluripotent stem cells (hiPSCs) represent a promising cell source for cartilage regeneration because of their self-renewal capacity and chondrogenic potential. However, the propensity of hiPSC-derived chondrocytes to undergo h...
α-Synuclein triggers intercellular nanotubes formation to prevent apoptosis in astroglia by promoting stemness [0.03%]
α-突触核蛋白通过促进干细胞特性触发星形胶质细胞间纳米管形成以防止其凋亡
Rachana Kashyap,B K Anirudh Sreenivas,M R Varshith et al.
Rachana Kashyap et al.
Astrocytes play a significant role in neuroprotection by internalizing neurodegenerative aggregates and facilitating their degradation. Recent studies indicate that α-Synuclein (α-SYN) protofibrils promote the transfer of pathogenic aggre...
Dual repression modes triggered by constitutively stabilized beta-catenin in the dorsal neural tube underlie cell fate alterations of the roof plate, neural crest, and dorsal interneurons [0.03%]
背侧神经管中组成性稳定β-连环蛋白引发的双重抑制模式决定了顶板、神经嵴和背侧间充质细胞命运的改变
Subbroto Kumar Saha,Tianyu Zhao,Kurt Reynolds et al.
Subbroto Kumar Saha et al.
The roof plate that covers the dorsal neural tube is a key organizer or signaling center that generates morphogenetic signaling proteins to regulate neural crest cell production and dorsal CNS patterning. However, knowledge remains limited ...
The ubiquitin E3 ligase TRIM59 in myeloid cell regulates complement C3 through degrading CCAAT/enhancer binding protein β to promote neuron survival after ischemic stroke [0.03%]
髓系细胞中的泛素E3连接酶TRIM59通过降解CCAAT/增强子结合蛋白β调节补体C3促进缺血性脑卒中后神经元的存活
Xiang Li,Xinjuan Tian,Jingjing Zhang et al.
Xiang Li et al.
Background: Ischemic stroke is a cerebrovascular disease that activates the complement system, leading to inflammation and neuronal injury. TRIM59, an E3 ubiquitin ligase, has been extensively studied in cancer, sepsis, a...