Epigallocatechin gallate from green tea effectively blocks infection of SARS-CoV-2 and new variants by inhibiting spike binding to ACE2 receptor [0.03%]
绿茶儿茶素表没食子儿茶素没食子酸酯通过抑制刺突与ACE2受体结合有效阻断SARS-CoV-2及新变异株感染
Jinbiao Liu,Brittany H Bodnar,Fengzhen Meng et al.
Jinbiao Liu et al.
Background: As the COVID-19 pandemic rages on, the new SARS-CoV-2 variants have emerged in the different regions of the world. These newly emerged variants have mutations in their spike (S) protein that may confer resista...
A novel mechanism for C1GALT1 in the regulation of gastric cancer progression [0.03%]
C1GALT1在胃癌进展中的新型调控机制研究
Xiaoxia Dong,Chunli Chen,Xinzhou Deng et al.
Xiaoxia Dong et al.
Background: Gastric cancer (GC) is a highly aggressive and lethal disease around the world. High expression of core 1 β 1, 3-galactosyltransferase 1 (C1GALT1), the primary enzyme responsible for protein O-glycosylation, ...
The mechanism of Annexin A1 to modulate TRPV1 and nociception in dorsal root ganglion neurons [0.03%]
annexin a1调节背根神经节神经元中trpv1和伤害性刺激的机制研究
Yufen Zhang,Sehui Ma,Xiao Ke et al.
Yufen Zhang et al.
Background: Annexin A1 (ANXA1) exerts anti-nociceptive effect through ANXA1 receptor formyl peptide receptor 2 (FPR2/ALX (receptor for lipoxin A4), FPR2) at the dorsal root ganglia (DRG) level. However, the mechanisms rem...
Intracellular proteome compartmentalization: a biotin ligase-based proximity labeling approach [0.03%]
基于生物素连接酶的邻近标记方法研究细胞内蛋白质组区室化现象
Olanrewaju Ayodeji Durojaye
Olanrewaju Ayodeji Durojaye
Specialized biological processes occur in different regions and organelles of the cell. Additionally, the function of proteins correlate greatly with their interactions and subcellular localization. Understanding the mechanism underlying th...
An update on novel approaches for diagnosis and treatment of SARS-CoV-2 infection [0.03%]
SARS-CoV-2感染诊断和治疗的新方法的更新报告
Azadeh Safarchi,Shadma Fatima,Zahra Ayati et al.
Azadeh Safarchi et al.
The ongoing pandemic of coronavirus disease 2019 (COVID-19) has made a serious public health and economic crisis worldwide which united global efforts to develop rapid, precise, and cost-efficient diagnostics, vaccines, and therapeutics. Nu...
Genetic composition and evolution of the prevalent Mycobacterium tuberculosis lineages 2 and 4 in the Chinese and Zhejiang Province populations [0.03%]
中国和浙江省人群常见结核分枝杆菌进化枝2号和4号的菌株组成与进化分析
Beibei Wu,Wenlong Zhu,Yue Wang et al.
Beibei Wu et al.
Background: There are seven human-adaptation lineages of Mycobacterium tuberculosis (Mtb). Tuberculosis (TB) dissemination is strongly influenced by human movements and host genetics. The detailed lineage distribution evo...
AKR1B10 promotes breast cancer cell proliferation and migration via the PI3K/AKT/NF-κB signaling pathway [0.03%]
AKR1B10通过PI3K/AKT/NF-κB信号通路促进乳腺癌细胞增殖和迁移
Jiayao Qu,Jia Li,Yaming Zhang et al.
Jiayao Qu et al.
Background: Aberrant expression of Aldo-Keto reductase family 1 member B10 (AKR1B10) was associated with tumor size and metastasis of breast cancer in our published preliminary studies. However, little is known about the ...
JAZF1 heterozygous knockout mice show altered adipose development and metabolism [0.03%]
杂合敲除小鼠Jazf1影响脂肪细胞发育和能量代谢
Jain Jeong,Soyoung Jang,Song Park et al.
Jain Jeong et al.
Background: Juxtaposed with another zinc finger protein 1 (JAZF1) is associated with metabolic disorders, including type 2 diabetes mellitus (T2DM). Several studies showed that JAZF1 and body fat mass are closely related....
Influence of miR-221/222 on cardiomyocyte calcium handling and function [0.03%]
miR-221/222对心肌细胞钙稳态及功能的影响
Maria Knyrim,Sindy Rabe,Claudia Grossmann et al.
Maria Knyrim et al.
Background: Cardiovascular disease is the leading cause of death worldwide. Cardiac electrical remodeling including altered ion channel expression and imbalance of calcium homeostasis can have detrimental effects on cardi...
Xin Zhou,Sui-Ning Xu,Shu-Tong Yuan et al.
Xin Zhou et al.
Background: Vascular calcification is a closely linked to cardiovascular diseases, such as atherosclerosis, chronic kidney disease, diabetes, hypertension and aging. The extent of vascular calcification is closely correla...