Blockade of the Arid5a/IL-6/STAT3 axis underlies the anti-inflammatory effect of Rbpjl in acute pancreatitis [0.03%]
Rbpjl通过阻断Arid5a/IL-6/STAT3轴发挥急性胰腺炎中的抗炎作用
Jiachen Lv,Min Fang,Shijie Sun et al.
Jiachen Lv et al.
Background: The microarray data analysis predicted that Rbpjl is poorly expressed in acute pancreatitis (AP). Activated IL-6/STAT3 signaling is further known to contribute to the progression of AP through immune regulatio...
Macrophages derived from pluripotent stem cells: prospective applications and research gaps [0.03%]
由多能干细胞衍生的巨噬细胞：前景、应用及研究缺口
Irina Lyadova,Andrei Vasiliev
Irina Lyadova
Induced pluripotent stem cells (iPSCs) represent a valuable cell source able to give rise to different cell types of the body. Among the various pathways of iPSC differentiation, the differentiation into macrophages is a recently developed ...
Post-synaptic specialization of the neuromuscular junction: junctional folds formation, function, and disorders [0.03%]
神经肌肉突触后专业化：突触皱褶的形成、功能及疾病
Suqi Zou,Bing-Xing Pan
Suqi Zou
Post-synaptic specialization is critical to the neurotransmitter release and action potential conduction. The neuromuscular junctions (NMJs) are the synapses between the motor neurons and muscle cells and have a more specialized post-synapt...
Genetics of cerebral malaria: pathogenesis, biomarkers and emerging therapeutic interventions [0.03%]
脑疟疾的遗传学：发病机制、生物标志物和新兴的治疗干预措施
Lydia Nkuah Nortey,Alberta Serwah Anning,Gideon Kwesi Nakotey et al.
Lydia Nkuah Nortey et al.
Background: Cerebral malaria (CM) is a preeminent cause of severe disease and premature deaths in Sub-Saharan Africa, where an estimated 90% of cases occur. The key features of CM are a deep, unarousable coma that persist...
IL-1R/C3aR signaling regulates synaptic pruning in the prefrontal cortex of depression [0.03%]
抑郁症前额叶皮层的IL-1R/C3aR信号调节突触修剪现象
Man-Man Zhang,Min-Xia Guo,Qiu-Ping Zhang et al.
Man-Man Zhang et al.
Background: Major depressive disorder is characterized by not only monoamine neurotransmitters deficiencies but also persistent neuroinflammation. The complement system is an attractive therapeutic target for various infl...
Dual function of SF3B2 on chromatin and RNA to regulate transcription in head and neck squamous cell carcinoma [0.03%]
SF3B2在头颈鳞状细胞癌中调控转录的染色质和RNA双重功能
Koji Kitamura,Hidefumi Suzuki,Ryota Abe et al.
Koji Kitamura et al.
RNA is spliced concomitantly with transcription and the process is organized by RNA splicing factors, transcriptional regulators, and chromatin regulators. RNA is spliced in close proximity to transcription machinery. Hence, some RNA splici...
H3K27ac mediated SS18/BAFs relocation regulates JUN induced pluripotent-somatic transition [0.03%]
SS18/BAFs 由 H3K27ac 介导的重定位调控 JUN 诱导多能性-体细胞转变
Runxia Lin,Ziwei Zhai,Junqi Kuang et al.
Runxia Lin et al.
Background: The exit from pluripotency or pluripotent-somatic transition (PST) landmarks an event of early mammalian embryonic development, representing a model for cell fate transition. ...
Both prokaryotes and eukaryotes produce an immune response against plasmids with 5'-GTTTGTT-3' [0.03%]
兼具原核和真核生物的免疫系统可以对含有5'-GTTTGTT-3'序列的质粒产生应答反应
Nan Li,Dongya Jiang,Luqingqing He et al.
Nan Li et al.
In the evolutionary "arms race" from prokaryotes to eukaryotes, some memories of foreign DNA have been conserved for defensive purposes. Shortly after invasion by the plasmid, pEGFP-N1, the conserved the defense gene, isg15, was activated i...
Inclusion of a dual signal sequence enhances the immunogenicity of a novel viral vectored vaccine against the capsular group B meningococcus [0.03%]
双信号序列的纳入增强了针对B群脑膜炎奈瑟菌新型病毒载体疫苗的免疫原性
Dylan Sheerin,Christina Dold,Laura Silva-Reyes et al.
Dylan Sheerin et al.
Background: Disease caused by the capsular group B meningococcus (MenB) is the leading cause of infectious death in UK infants. A novel adenovirus-based vaccine encoding the MenB factor H binding protein (fHbp) with an N-...
Development of a novel human CD147 knock-in NSG mouse model to test SARS-CoV-2 viral infection [0.03%]
开发用于测试新型冠状病毒(SARS-CoV-2)感染的新型人源CD147敲入NSG小鼠模型
Saiaditya Badeti,Qingkui Jiang,Alireza Naghizadeh et al.
Saiaditya Badeti et al.
Background: An animal model that can mimic the SARS-CoV-2 infection in humans is critical to understanding the rapidly evolving SARS-CoV-2 virus and for development of prophylactic and therapeutic strategies to combat eme...