Combination of GLP-1 receptor agonist and Akkermansia muciniphila Akk11 reduces adiposity and ameliorates MASLD in T2D mice [0.03%]
GLP-1受体激动剂与Akkermansia muciniphila Akk11联合应用可减轻小鼠肥胖并改善T2D小鼠MASLD病理生理学症状
Kaige Gao,Zaifei Yin,Chi Zhang et al.
Kaige Gao et al.
Aims/hypothesis: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a leading cause of chronic liver disease globally and is closely associated with type 2 diabetes (T2D) and obesity. Glucagon-like peptid...
Maternal hyperhomocysteinemia induces fetal growth restriction by suppressing angiogenesis at the maternal-fetal interface [0.03%]
高同型半胱氨酸血症通过抑制母胎界面上的血管生成诱导胎儿生长受限
Sujuan Li,Yichi Wu,Yuan Gao et al.
Sujuan Li et al.
Maternal hyperhomocysteinemia (HHcy) is closely linked to fetal growth restriction (FGR), yet the underlying mechanisms remain incompletely understood. In this study, we established a rat model of HHcy by administering a high-methionine die...
IL-27 signaling mediates skin inflammation in experimental psoriasis and atopic dermatitis [0.03%]
实验性银屑病和特应性皮炎中的皮肤炎症介导_IL-27信号通路
Zeyu Chen,Lian Cui,Zhiyi Lan et al.
Zeyu Chen et al.
Background: Psoriasis and atopic dermatitis (AD) are two prevalent inflammatory skin disorders, each characterized by distinct adaptive immune responses. However, recent evidence suggests that these diseases may share ove...
TGF-β1/SMAD signaling downregulates KLF4 expression via direct transcriptional suppression and FAT10-mediated proteasomal degradation in hepatocellular carcinoma [0.03%]
TGF-β1/SMAD信号通过直接转录抑制和FAT10介导的蛋白酶体降解下调肝癌中KLF4表达
Zeping Chen,Senlin Zhao,Desheng Chen et al.
Zeping Chen et al.
Background: Loss of tumor suppressor Krüpple-like factor 4 (KLF4) expression in hepatocellular carcinoma (HCC) is crucial for aggressive tumor progression and poor patient prognosis. However, the mechanisms underlying KL...
Zinc finger protein ZNF33B facilitates Japanese encephalitis virus replication by regulating m6A modification on Ifih1 and Irf3 transcripts to antagonize antiviral response [0.03%]
锌指蛋白ZNF33B通过调节Ifih1和Irf3转录本上的m6A修饰来促进日本脑炎病毒的复制以对抗抗病毒反应
Jian Du,Chunwei Li,Jinyan Zhang et al.
Jian Du et al.
Japanese encephalitis virus (JEV), a neurotropic flavivirus, poses a significant public health threat, yet the molecular mechanisms underlying its interaction with host immunity remain poorly understood. This study reveals that zinc finger ...
Fusion oncoproteins orchestrate tumorigenesis and sustain malignant progression via a positive feedback mechanism [0.03%]
融合癌蛋白通过正反馈机制协调肿瘤发生并维持恶性进展
Wenwen Ying,Xiaomin Wang,Jiayi Yu et al.
Wenwen Ying et al.
Chromosomal translocations are prevalent genetic events across multiple pediatric cancers, notably in CNS tumors, solid tumors, and leukemias. For decades, Fusion oncoproteins resulting from chromosomal translocations have been proposed as ...
Anti-seizure potential of J4, an equilibrative nucleoside transporter 1 inhibitor, in a mouse model of tuberous sclerosis complex in response to pentylenetetrazol [0.03%]
J4(平衡核苷转运蛋白1抑制剂)在戊四唑反应性结节性硬化小鼠模型中的抗癫痫潜能研究
Christine Chin-Jung Hsieh,Nai-Kuei Huang,Szu-Yu Tung et al.
Christine Chin-Jung Hsieh et al.
Tuberous sclerosis complex (TSC) is a neurodevelopmental disorder with epileptic seizures caused by genetic mutations in either TSC1 or TSC2 gene. Multiple genetic, epigenetic, and environmental factors can affect the phenotypical outcomes ...
Mechanisms, efficacy, and future perspectives of cellular-based therapies for liver fibrosis/cirrhosis: focusing on mesenchymal stromal cells [0.03%]
肝纤维化/肝硬化细胞治疗的机制、疗效及未来前景：侧重于间充质基质细胞
Xuan Pan,Tianyun Gao,Bin Wang
Xuan Pan
Liver fibrosis/cirrhosis, characterized by excessive deposition of extracellular matrix (ECM) and formation of fibrous scars, arises from chronic liver injury and poses a significant global health burden. Although liver transplantation rema...
Recombinant attenuated Salmonella vaccine promotes CD8+ T cell-dependent antitumor immunity via IFN-γ-induced IRF-1-mediated upregulation of IL-7 [0.03%]
干扰素-γ诱导的IRF-1介导的白细胞介素-7上调促进重组减毒沙门氏菌疫苗诱发CD8+T细胞依赖性抗肿瘤免疫作用
Jae-Hyeon Jeong,Dae-Joon Kim,Chae-Won Kim et al.
Jae-Hyeon Jeong et al.
Background: Cancer is a leading cause of mortality worldwide, necessitating the development of novel therapeutic targets and strategies to prevent recurrence and metastasis. In this study, we aimed to evaluate whether a r...
ZMIZ2 interacts with PIN1 to promote lung adenocarcinoma EMT and metastasis via activation of the PI3K/AKT pathway [0.03%]
ZMIZ2通过激活PI3K/AKT信号通路与PIN1相互作用促进肺腺癌EMT和转移
Zhiyue Su,Yuhong Wang,Ersuo Jin et al.
Zhiyue Su et al.
ZMIZ2, a transcription co-activator, is frequently overexpressed in various tumors. However, its functional role and molecular mechanisms in driving non-small cell lung cancer (NSCLC) metastasis remain elusive. Our study reveals that ZMIZ2 ...