The methyltransferase activity of Dot1L is essential for Xenopus tropicalis tadpole development and survival
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Epigenetic modifications of histones play key roles in transcriptional regulation by diverse transcription factors. One such modification is the methylation of histone H3 at lysine 79 (H3K79). The methyltransferase DOT1L is the only known, highly conserved enz... ...
