Cadmium impairs heart ventricular formation and disrupts polysialylated-NCAM/FGF receptor signaling in Xenopus tadpoles [0.03%]
镉通过破坏Xenopus蝌蚪中多唾液酸化-NCAM/FGF受体信号干扰心室形成
Pélagie Douchez,Ingrid Fliniaux,Yoshiko Takeda-Uchimura et al.
Pélagie Douchez et al.
Background: Exposure to cadmium, a trace metallic element, is a major health concern. Cadmium is associated with a higher risk and predisposition to cardiovascular disease. Identifying molecular targets involved in such a...
Inhibition of PTEN nuclear translocation by peptide Tat-K13 attenuates p-JUN-SESN2-AMPK-dependent autophagy and enhances neurological recovery after neonatal hypoxic-ischemic brain damage [0.03%]
PTEN核转位抑制肽Tat-K13通过削弱p-JUN-SESN2-AMPK依赖的自噬促进缺氧缺血性脑损伤后的神经功能恢复
Chunfang Dai,Xiaobin Wu,Xiaohuan Li et al.
Chunfang Dai et al.
Neuronal death triggered by hypoxia-ischemia (HI) is a major cause of neonatal mortality and long-term neurological deficits. Excessive autophagy plays a pathogenic role in neonatal hypoxic-ischemic encephalopathy (HIE), and inhibition of p...
Correction: RBX1 regulates PKM alternative splicing to facilitate anaplastic thyroid carcinoma metastasis and aerobic glycolysis by destroying the SMAR1/HDAC6 complex [0.03%]
校正：RBX1通过破坏SMAR1/HDAC6复合物来调节PKM的可变剪接以促进甲状腺未分化癌转移和糖酵解上调
Debin Xu,Jichun Yu,Yuting Yang et al.
Debin Xu et al.
Published Erratum
Cell & bioscience. 2026 Apr 28;16(1):44. DOI:10.1186/s13578-026-01560-9 2026
Poly-GR promotes ferroptosis-associated vulnerability in C9orf72-ALS [0.03%]
Poly-GR促进C9orf72-ALS铁死亡相关易感性
Chun-Yu Lin,Wen-Chi Hsieh,Shao-Ming Wang
Chun-Yu Lin
Ferroptosis, an iron-dependent form of oxidative cell death driven by uncontrolled lipid peroxidation, has been increasingly implicated in neurodegeneration. However, its involvement and the underlying regulatory mechanism in C9orf72-linked...
SIAH2-EPHB6 axis enhances filopodia formation in hepatocellular carcinoma cells by regulating RHOF [0.03%]
SIAH2-EPHB6轴通过调节RHOF增强肝癌细胞的丝状伪足形成
Qinghe Hu,Kai Wu,Zhiyi Liu et al.
Qinghe Hu et al.
Seven in absentia homologue 2 (SIAH2) has been shown to contribute to the progression of various human tumors, including hepatocellular carcinoma (HCC). However, the precise mechanisms by which SIAH2 promotes HCC cell migration remain to be...
Integrator subunit IntS11 orchestrates the temporal dynamics of neural lineage progression in Drosophila [0.03%]
整合子亚基IntS11调控果蝇神经谱系发育的动态过程
Qiao Xiao,Liqiang Ai,Boquan Jia et al.
Qiao Xiao et al.
Background: IntS11, the core catalytic subunit of the Integrator (INT), functions in various stages of transcription. However, its specific function in orchestrating neural lineage progression remains poorly understood. ...
SIRT5-RNF126 coordinated regulation of METTL17 stability controls mitochondrial function and glioma progression [0.03%]
SIRT5-RNF126调控METTL17稳定性控制线粒体功能和胶质瘤进展
Chunyan He,Zixiao Zhang,Xiaoke Wu et al.
Chunyan He et al.
Gliomas are highly invasive brain tumors in which metabolic reprogramming plays a pivotal role in tumor initiation and progression. METTL17, a mitochondria-associated methyltransferase, has been reported to enhance oxidative phosphorylation...
A mouse model of HPV-associated cervicovaginal carcinosarcoma with comparative analysis to human clinical cases [0.03%]
人乳头瘤病毒相关宫颈阴道癌肉瘤的小鼠模型及与人类临床病例的比较分析
Jason Murray,Shiwen Peng,Chien-Fu Hung et al.
Jason Murray et al.
Background: Carcinosarcomas of the gynecologic tract, previously referred to as malignant mixed müllerian/mesodermal tumor, are devastating malignancies that remain poorly studied due to their rarity and the lack of rele...
Lactate metabolic reprogramming and lactylation modification: molecular mechanisms reshaping the tumor immunosuppressive microenvironment [0.03%]
乳酸代谢重构与乳酰化修饰：重塑肿瘤免疫抑制微环境的分子机制
Yuzhang Yuan,Yaping Gao,Jinhui Xue et al.
Yuzhang Yuan et al.
CircRSPRY1 regulates calcium oxalate crystal-induced necrotic apoptosis in renal tubules via miR-21-5p/PTEN [0.03%]
Circular RNA RSPRY1通过miR-21-5p/PTEN轴调节肾小管钙氧化物晶体诱导的坏死性凋亡
Xudong Shen,Xike Mao,Hu Liang et al.
Xudong Shen et al.