Single-cell RNA sequencing reveals immune-peritubular myoid cell crosstalk driving testicular interstitial fibrosis in idiopathic non-obstructive azoospermia [0.03%]
单细胞RNA测序揭示免疫-直精小管肌样细胞相互作用驱动特发性非梗阻性无精子症的睾丸间质纤维化
Xiaofeng Tan,Junlong Zhang,Qiyun Yang et al.
Xiaofeng Tan et al.
Infertility is a major global health challenge, and non-obstructive azoospermia (NOA) represents the most severe form of male infertility. While a small proportion of NOA cases are caused by congenital factors, the majority arise from unkno...
Ashaq Hussain,Marc Tatar,Rujun Gong
Ashaq Hussain
Senescence is an adaptive cellular mechanism initiated in response to diversified intrinsic and extrinsic stress stimuli, that lead to altered cellular and pathophysiological state. In this article we will review the comprehensive role of v...
CRISPR diagnostics: from trans-nuclease activity to cancer diagnosis [0.03%]
基于CRISPR的诊断技术：从转录酶活性到癌症诊断
Lei Chang,Wenjue Xu,Xiaoyan Wang et al.
Lei Chang et al.
The field of nucleic acid-based testing experienced a decade-long stagnation since the development of quantitative polymerase chain reaction (qPCR) in 1992 and isothermal amplification methods in the early 2000s. However, in 2016, the disco...
ERO1L induces macrophage infiltration to potentiate KrasG12D and inflammation-induced pancreatic tumorigenesis via oxidative protein folding of CCL2 [0.03%]
ERO1L通过氧化型蛋白质折叠CCL2诱导巨噬细胞浸润以促进KrasG12D和炎症诱导的胰腺肿瘤发生
Junfeng Zhang,Chengyu Hu,Yannan Xu et al.
Junfeng Zhang et al.
Pancreatitis is a significant risk factor for pancreatic cancer, with Kras mutations being the most common in this malignancy. Inflammation accelerates tumorigenesis driven by Kras mutations. However, the interactions between inflammation a...
5'-end uridine-derived base modification for siRNAs potency reinforcement [0.03%]
用于增强siRNA活性的5'-端尿嘧啶来源的碱基修饰
Yuqi Yao,Xinming Qi,Ruimin Huang et al.
Yuqi Yao et al.
Small interfering RNAs (siRNAs), bound by Argonaute, efficiently cleave target mRNAs through full complementary base pairing, achieving potent gene silencing. While chemical modifications are widely employed to improve siRNA stability and b...
Multi-omic analysis reveals Wharton's jelly mesenchymal stem cells shift the pro-inflammatory phenotype of fibroblast subpopulation to induce skin rejuvenation [0.03%]
多组学分析揭示沃顿胶间充质干细胞通过改变成纤维细胞亚群的促炎表型来诱导皮肤年轻化
Penghong Chen,Yiqun Qiu,Jiyao Li et al.
Penghong Chen et al.
Background: Skin aging is an increasingly serious clinical problem with limited treatment options. Wharton's jelly mesenchymal stem cells (WJMSCs) represent a promising regenerative strategy. However, their mechanisms of ...
Macrophage PSRC1 attenuates atherosclerosis via extracellular vesicle-mediated MBD2 delivery to induce PCSK9 promoter methylation in hepatocytes [0.03%]
巨噬细胞PSRC1通过分泌微泡介导肝细胞MBD2递送来诱导PCSK9启动子甲基化从而抑制动脉粥样硬化发展
Tongwei Wu,Hui Huang,Xiaoqian Zhang et al.
Tongwei Wu et al.
Background: Atherosclerotic cardiovascular disease (ASCVD) is driven by dysregulated lipid metabolism and chronic inflammation. However, the mechanisms governing immune-liver crosstalk in this context remain poorly define...
RNF214 silencing attenuates prostate cancer progression and modulates mTOR signaling through CAV1 ubiquitination [0.03%]
RNF214沉默通过CAV1泛素化减缓前列腺癌进展并调节mTOR信号通路
Zongqiang Wu,Zhiming Huang,Shangfan Liao
Zongqiang Wu
Background: Although both RNF214 and CAV1 are implicated in tumor progression and signaling regulation, the role of the RNF214-CAV1 axis in prostate cancer (PCa) remains unclear. This study aims to explore how RNF214 modu...
A segregating PTK2B variant in a primary biliary cholangitis (PBC) family induces PBC-like autoimmune features in knock-in mice [0.03%]
一种PTK2B新型突变在原发性胆汁性胆管炎(PBC)家系中诱导敲入小鼠产生类似自身免疫表型
Sainan Bian,Yanlei Yang,Zhilei Chen et al.
Sainan Bian et al.
Background: Primary biliary cholangitis (PBC) is a chronic autoimmune cholestatic liver disease with an incompletely understood genetic basis. This study aimed to identify disease-causing genetic variants in a PBC family ...
Human small non-coding tRNA-derived fragments as key hallmarks of host-virus interaction in viral infections [0.03%]
人类小型非编码tRNA衍生片段在病毒感染中作为宿主-病毒相互作用的关键标志
Mahsa Aghajani Mir,Parisa Sharifi,Fatemeh Gila et al.
Mahsa Aghajani Mir et al.
Viral infections cause deep changes in the host transcriptome, triggering a complex antiviral immune response that involves multiple proteins and molecular and cellular signaling pathways. Traditionally, Transfer RNAs (tRNAs) have been iden...