The chromatin reader Dido3 is a regulator of the gene network that controls B cell differentiation [0.03%]
染色质阅读器DIDO3调控B细胞分化基因网络
Fernando Gutiérrez Del Burgo,María Ángeles García-López,Tirso Pons et al.
Fernando Gutiérrez Del Burgo et al.
The development of hematopoietic cell lineages is a highly complex process governed by a delicate interplay of various transcription factors. The expression of these factors is influenced, in part, by epigenetic signatures that define each ...
Zmynd11 is essential for neurogenesis by coordinating H3K36me3 modification of Epha2 and PI3K signaling pathway [0.03%]
Zmynd11通过协调Epha2的H3K36me3修饰和PI3K信号通路对神经发生是必不可少的
Xu Yang,Lan Li,Wenzheng Qu et al.
Xu Yang et al.
10p15.3 deletion syndrome is caused by the deficiency of MYND-type zinc finger domain-containing protein 11 (ZMYND11) and featured by global developmental delay, intellectual disability, behavioral abnormalities, etc. Although the roles of ...
A BioID-based approach uncovers the interactome of hexose-6-phosphate dehydrogenase in breast cancer cells and identifies anterior gradient protein 2 as an interacting partner [0.03%]
基于BioID方法揭示乳腺癌细胞中己酮糖六磷酸脱氢酶的相互作用组并鉴定其互作蛋白.gradient同源蛋白2
Gabriele Sakalauskaite,Michael Weingartner,Sophie Ebert et al.
Gabriele Sakalauskaite et al.
Background: Hexose-6-phosphate dehydrogenase (H6PD) catalyzes the first two steps of the pentose-phosphate-pathway (PPP) within the endoplasmic reticulum, generating NADPH. H6PD modulates essential physiological processes...
Chenchen Wang,Junshi Zhang,Yali Xu et al.
Chenchen Wang et al.
Background: Foamy viruses (FVs), a unique class of retroviruses, establish lifelong latent infections in the host without causing symptoms, contributing to the relatively slow progress in FV research. However, key mutatio...
CRISPR/Cas-mediated mRNA knockdown in the embryos of Xenopus tropicalis [0.03%]
非洲爪蟾胚胎中基于CRISPR / Cas的mRNA干扰技术
Xiao-Lin Lin,Yi-Min Zhou,Ke Meng et al.
Xiao-Lin Lin et al.
The Xenopus tropicalis (Western clawed frog) is an important amphibian model for genetics, developmental and regenerative biology, due to its diploid genetic background and short generation time. CRISPR-Cas13 and CRISPR interference (CRISPR...
Huddling behavior regulate adaptive thermogenesis in Brandt's voles (Lasiopodomys brandtii) [0.03%]
集群行为调节布兰特黄鼠适应性产热的行为及机制研究
Min Liu,De-Sheng Zou,Xue-Ying Zhang et al.
Min Liu et al.
Background: Brown adipose tissue (BAT) is the main site of non-shivering thermogenesis (NST) in small mammals, playing an important role in maintaining body temperature and energy balance. Huddling is a behavioral strateg...
Peptides targeting RAB11A-FIP2 complex inhibit HPIV3, RSV, and IAV replication as broad-spectrum antivirals [0.03%]
靶向RAB11A-FIP2复合体的多肽可抑制HPIV3、RSV和IAV复制并广谱抗病毒
Yanliang Jiang,Yongliang Zhao,Jie Deng et al.
Yanliang Jiang et al.
Background: The cytoskeletal framework plays a critical role in the early stages of human parainfluenza virus type 3 (HPIV3) replication, including viral mRNA synthesis and translation. However, its contribution to later ...
Molecular mechanisms of endothelial-mesenchymal transition and its pathophysiological feature in cerebrovascular disease [0.03%]
内皮-间充质转化在脑血管病中的分子机制及其病理生理特征
Huimin Jiang,Yifan Zhou,Weiyue Zhang et al.
Huimin Jiang et al.
The phenomenon of endothelial-mesenchymal transition (EndMT), a distinct subtype of epithelial-mesenchymal transition (EMT), has garnered significant attention from scholars. EndMT refers to the process whereby endothelial cells (ECs) trans...
Nicotinamide mononucleotide promotes female germline stem cell proliferation by activating the H4K16ac-Hmgb1-Fyn-PLD signaling pathway through epigenetic remodeling [0.03%]
烟酸单核苷酸通过表观遗传重编程激活组蛋白乙酰化H4K16ac-Hmgb1-Fyn-PLD信号促进雌性生殖干细胞增殖
Hong Zhou,Yujie Liu,Geng G Tian et al.
Hong Zhou et al.
Background: Nicotinamide mononucleotide (NMN), an endogenous nucleotide essential for various physiological processes, has an unclear role and regulatory mechanisms in female germline stem cell (FGSC) development. ...
Distribution of gut microbiota across intestinal segments and their impact on human physiological and pathological processes [0.03%]
肠道微生物区系的肠段分布及其对人体生理性、病理性过程的影响
Ke Yang,Guangqin Li,Qihong Li et al.
Ke Yang et al.
In recent years, advancements in metagenomics, metabolomics, and single-cell sequencing have enhanced our understanding of the intricate relationships between gut microbiota and their hosts. Gut microbiota colonize humans from birth, with t...