Bo Li,Yu-Ying He,Zeng-Ming Yang
Bo Li
Primary cilia are solitary, non-motile, microtubule-based organelles that protrude from the surface of most vertebrate cells, functioning as highly specialized sensory and signaling compartments. Architecturally, they comprise the basal bod...
Deciphering the epigenomic regulatory variations reveals function diversity in adipose lineage among different adipose depots of pigs [0.03%]
解析表观基因组调控变异可揭示猪不同脂肪组织谱系的功能多样性
Daoyuan Wang,Renzhuo Kuang,Mingyang Hu et al.
Daoyuan Wang et al.
The distribution of adipose depots in different body parts affects pig production value and human health, governed by complex epigenomic mechanisms. Limited studies on pig adipose depots have hindered the genetic improvement of fat-related ...
KDM6B inhibition enhances chemotherapeutic response in small cell lung cancer via epigenetic regulation of apoptosis and ferroptosis [0.03%]
表观遗传调控凋亡和铁死亡KDM6B抑制增强小细胞肺癌的化疗反应
Zhongliang Wang,Ziyuan Liu,Yufan Yang et al.
Zhongliang Wang et al.
Background: Small cell lung cancer (SCLC) is a highly aggressive malignancy characterized by rapid progression and the frequent emergence of resistance to standard chemotherapeutic agents such as cisplatin (DDP) and etopo...
PRMT1 drives oral squamous cell carcinoma progression by activating STAT3 and suppressing ferroptosis via GPX4 [0.03%]
脯氨酰-tRNA合成酶(PRMT1)通过激活STAT3和抑制GPX4介导的铁死亡驱动口腔鳞状细胞癌进展
Huawei Liu,Chuyan Shi,Bing Liu et al.
Huawei Liu et al.
Background: Oral squamous cell carcinoma (OSCC) exhibits poor prognosis due to aggression, metastasis, and chemoresistance. Protein Arginine Methyltransferase 1 (PRMT1) and Signal Transducer and Activator of Transcription...
Increased pulmonary blood flow leads to alveolar dysplasia during the early postnatal developmental stage [0.03%]
出生后早期增加肺血流量可致肺泡发育异常
He Zhang,Sixie Zheng,Zheng Wang et al.
He Zhang et al.
Background: Increased pulmonary blood flow (IncPBF), one of the most important features of many children with congenital heart diseases, is well-known as a prerequisite for the induction of pulmonary arterial hypertension...
RNA-binding protein PTBP1 mediates HSV-1 attachment and infection through regulation of heparan sulfate 3-O-sulfotransferase gene expression [0.03%]
RNA结合蛋白PTBP1通过调节硫酸肝素皮酰氧基硫酸转移酶基因表达介导HSV-1黏附和感染
Weikang Sun,Mengyu Zhang,Ruilin Wang et al.
Weikang Sun et al.
Background: The RNA-binding protein polypyrimidine tract-binding protein 1 (PTBP1), also known as heterogeneous nuclear ribonucleoprotein I (hnRNP I), mediates gene expression through splicing regulation. Its role in viru...
Multi-omics analysis of the HMGB2+ tumor epithelial cells in lactylation subgroups in colorectal cancer [0.03%]
结直肠癌乳酰化亚群中HMGB2+肿瘤上皮细胞的多组学分析
Shangshang Hu,Jinwei Lou,Muzi Ding et al.
Shangshang Hu et al.
Colorectal cancer (CRC) is a prevalent malignancy, yet the role of lactylation in its progression remains unclear. This study investigates High Mobility Group Box 2 positive tumor epithelial cells (HMGB2+Epi), a lactylation-associated subpo...
From pathogenesis to therapeutic targeting: new insight into TAM receptors in rheumatoid arthritis [0.03%]
从发病机理到治疗作用：炎性关节病中TAM受体的新认识
Mengli Dai,Xuezhi Yang,Feng Yao et al.
Mengli Dai et al.
Rheumatoid arthritis (RA), a systemic autoimmune disorder driven by chronic joint inflammation and progressive tissue damage, is orchestrated by a complex interplay of immune cells and signaling pathways. Among these, the TAM receptor famil...
Neuronal differentiation regulator CEND1 coordinately suppresses tumor growth and energetics via AMPK signaling in brain glioma [0.03%]
神经元分化调节因子CEND1通过AMPK信号协同抑制脑胶质瘤生长和能量代谢
Yuting Shu,Yunbo Yuan,Yuze He et al.
Yuting Shu et al.
The aggressive proliferation and metabolic adaptability of glioma contribute to poor clinical prognosis, necessitating novel targets concurrently reprogram glioma cells toward a neuron-like, less proliferative, and metabolically suppressed ...
Single-cell transcriptome analysis profiles the enlarged subsets of myeloid-biased HSPCs with preleukemic characters in disuse osteoporosis mice [0.03%]
单细胞转录组分析描绘了废用性骨质疏松小鼠中具有白血病前期特征的髓系偏移造血干细胞扩增亚群
Chen Zhang,Yueru Ji,Xiaotong Gao et al.
Chen Zhang et al.
Background: Osteoporosis (OP) could lead to the alteration of bone marrow microenvironment and non-homeostasis of hematopoiesis, which could increase the incidence of hematologic malignancies. However, whether myeloid-bia...