Macrophage PSRC1 attenuates atherosclerosis via extracellular vesicle-mediated MBD2 delivery to induce PCSK9 promoter methylation in hepatocytes [0.03%]
巨噬细胞PSRC1通过分泌微泡介导肝细胞MBD2递送来诱导PCSK9启动子甲基化从而抑制动脉粥样硬化发展
Tongwei Wu,Hui Huang,Xiaoqian Zhang et al.
Tongwei Wu et al.
Background: Atherosclerotic cardiovascular disease (ASCVD) is driven by dysregulated lipid metabolism and chronic inflammation. However, the mechanisms governing immune-liver crosstalk in this context remain poorly define...
RNF214 silencing attenuates prostate cancer progression and modulates mTOR signaling through CAV1 ubiquitination [0.03%]
RNF214沉默通过CAV1泛素化减缓前列腺癌进展并调节mTOR信号通路
Zongqiang Wu,Zhiming Huang,Shangfan Liao
Zongqiang Wu
Background: Although both RNF214 and CAV1 are implicated in tumor progression and signaling regulation, the role of the RNF214-CAV1 axis in prostate cancer (PCa) remains unclear. This study aims to explore how RNF214 modu...
A segregating PTK2B variant in a primary biliary cholangitis (PBC) family induces PBC-like autoimmune features in knock-in mice [0.03%]
一种PTK2B新型突变在原发性胆汁性胆管炎(PBC)家系中诱导敲入小鼠产生类似自身免疫表型
Sainan Bian,Yanlei Yang,Zhilei Chen et al.
Sainan Bian et al.
Background: Primary biliary cholangitis (PBC) is a chronic autoimmune cholestatic liver disease with an incompletely understood genetic basis. This study aimed to identify disease-causing genetic variants in a PBC family ...
Human small non-coding tRNA-derived fragments as key hallmarks of host-virus interaction in viral infections [0.03%]
人类小型非编码tRNA衍生片段在病毒感染中作为宿主-病毒相互作用的关键标志
Mahsa Aghajani Mir,Parisa Sharifi,Fatemeh Gila et al.
Mahsa Aghajani Mir et al.
Viral infections cause deep changes in the host transcriptome, triggering a complex antiviral immune response that involves multiple proteins and molecular and cellular signaling pathways. Traditionally, Transfer RNAs (tRNAs) have been iden...
ELYS promotes hepatocellular carcinoma stemness by activating a FOXO6-NUP205 transcriptional module downstream of PI3K/AKT to drive Hedgehog signaling [0.03%]
ELYLS通过激活FOXO6-NUP205转录模块促进肝癌干细胞特性来驱动Hedgehog信号通路
Xin Chen,Qing Zhang,Fen Xie et al.
Xin Chen et al.
Background: Hepatocellular carcinoma (HCC) is a lethal malignancy driven by cancer stem cells, which drive progression and therapeutic resistance. Nuclear pore protein ELYS is implicated in tumorigenesis, but its role in ...
lncRNA-operated stem cell fate control: RPS3 mediates the in situ Gm16751-Zhx3 interactome to program spermatogonial stem cell differentiation [0.03%]
长非编码RNA操控干细胞分化命运：RPS3介导Gm16751-Zhx3原位蛋白互作簇调控精原干细胞分化编程
Weijun Gao,Bo Xu,Wenzhi Ma et al.
Weijun Gao et al.
Background: Long non-coding RNAs (lncRNAs) play pivotal regulatory roles in mammalian male gametogenesis. Advances in high-throughput technologies have demonstrated that lncRNAs orchestrate robust, flexible, and context-s...
Epineuronal space: an emerging hidden hierarchy bridges neuron and mind space [0.03%]
围绕神经原的空隙：一个新兴的隐性等级制度连接神经元和心灵空间
Yi-Xi Zhang,Qiang-Long You,Xiang-Dong Sun
Yi-Xi Zhang
The emergent nature of life hinders reductionist paradigms of mapping microscale fundamental components with macroscale phenotypes. Such dilemma of mapping problems can be resolved through seeking hidden hierarchies among them. In developme...
Brain-wide spatiotemporal mapping of glutamate/GABA dual-transmitter neurons during postnatal development in mice [0.03%]
小鼠出生后发育期间谷氨酸/γ-氨基丁酸双递质神经元的脑区时空图谱
Cong Zhou,Shihan Cheng,Haofu Zheng et al.
Cong Zhou et al.
Emerging evidence suggests that individual neurons can utilize multiple neurotransmitters, challenging traditional views of neuronal identity. However, as most studies to date have focused on the adult stage, a fundamental question remains:...
Decoding the role of H19 in cholestatic liver injury using snRNA-seq, spatial transcriptomics, and machine learning-based disease prediction [0.03%]
使用snRNA测序、空间转录组学和基于机器学习的疾病预测解码H19在胆汁淤积性肝损伤中的作用
Grayson W Way,Xixian Jiang,Hongkun Lu et al.
Grayson W Way et al.
Background: Despite recent advances, Primary Sclerosing Cholangitis (PSC)-a chronic obstructive biliary disease-still lacks effective therapies to prevent disease progression or the need for liver transplantation. Moreove...
Neddylation is indispensable for early meiotic progression in spermatocytes via destabilizing HORMAD1 by SCF ubiquitin E3 ligase during synapsis [0.03%]
通过SCF泛素E3连接酶在联会过程中降解HORMAD1， Neddylation对精子细胞早期减数分裂进程至关重要
Ningyuan Tang,Qinghua Guo,Wenzhen Zhao et al.
Ningyuan Tang et al.
Background: The organized chromatin configuration in meiosis prophase I is crucial for spermatogenesis and male fertility, involving a series of tightly coordinated events mediated by numerous proteins. Neddylation, a ubi...