Cryptoxanthin as a multitarget neuroprotective agent: mechanistic and in silico perspectives [0.03%]
作为一种多靶点神经保护剂的隐黄素：机制和计算视角
Arjun Sadhukhan,Abhishek Chauhan,Mohit Kumar et al.
Arjun Sadhukhan et al.
Objectives: Neurodegenerative diseases such as Parkinson's disease (PD), Huntington's disease (HD), Alzheimer's disease (AD), and Amyotrophic lateral sclerosis (ALS) are complex disorders driven by multiple pathological p...
Allyl isothiocyanate ameliorates collagen-induced arthritis via mast cells and the pim1 pathway [0.03%]
allyl异硫氰酸盐通过肥大细胞和pim1通路改善胶原诱导的关节炎
Heng Wang,Yiying Wang,Ronghao Zhang et al.
Heng Wang et al.
Objectives: The present study explored whether allyl isothiocyanate from the traditional Chinese medicine mustard seed, ameliorated the arthritis by modulating immune cell responses, particularly by inhibiting mast cell a...
Protective effects and mechanisms of Panax notoginseng saponins against gp120-induced cognitive impairment: a network pharmacology and metabolomics study [0.03%]
三七总皂苷防治gp120致小鼠认知障碍的保护效应及机制研究：网络药理学和代谢组学分析
Mingyu Huang,Yijun Zhou,Shan Li et al.
Mingyu Huang et al.
Objective: This study investigates Panax notoginseng saponins (PNS) as a potential treatment for gp120-induced HIV-associated neurocognitive disorder (HAND), in light of the limited efficacy of current therapies. ...
Delonix regia flower extract protects against diabetic cardiac remodeling via modulating eNOS/NO/cGMP and NF-κB/iNOS/TNF-α trajectories [0.03%]
Delonix regia花提取物通过调节eNOS / NO / cGMP和NF-κB / iNOS / TNF-α轨迹保护糖尿病心脏重塑
Nadia Hassan,Maged Mohamed,Noura A Hassan et al.
Nadia Hassan et al.
Objectives: This study aimed to elucidate potential mechanisms associated with the cardioprotective efficacy of methanolic Delonix regia extract against the pathophysiological diabetic cardiac remodeling. ...
Sex differences in chemotherapy-induced neuropathic pain: mechanisms and pharmacotherapy [0.03%]
化疗引起的神经病理性疼痛的性别差异：机制和药物治疗
Xuewei Wu,Litao Chen,Yushan Chen et al.
Xuewei Wu et al.
Objectives: Chemotherapy-induced peripheral neuropathy (CIPN) is a common and serious side effect of cancer treatment. Studies have shown that there is significant sexual dimorphism in animal models, molecular mechanisms ...
Capilliposide from Lysimachia capillipes Hemsl. shows anti-inflammatory and anti-pyretic effects via the MAPK/iNOS/NF-κB pathway [0.03%]
石龙尾植物中具有抗炎和解热作用的单体化合物研究
Fanwei Xia,Junyu Zhang,Dongbiao Lu et al.
Fanwei Xia et al.
Objectives: To clarify the antipyretic efficacy of Capilliposide (LC) and investigate its antipyretic mechanism. Methods: Dry yeast was...
In silico designing of palbociclib loaded PLGA long-acting intramuscular injection for palliative therapy of HR+/HER2- metastatic breast cancer [0.03%]
用于HR+/HER2-转移性乳腺癌姑息治疗的palbociclib载药PLGA长效肌肉注射制剂的计算机辅助设计
Rutuja Suryawanshi,Anumol Joseph,Rajkumar Malayandi
Rutuja Suryawanshi
Objectives: Palbociclib (PBB) is an oral cyclin-dependent kinase 4/6 (CDK4/6) inhibitor approved for the treatment of HR+/HER2- breast cancer. However, poor adherence and limited tolerability of oral administration often ...
From plant pair to gastroprotection: chemical standardization and in vivo validation of Akebiae Fructus-Hoveniae semen against ethanol-mediated mucosal damage [0.03%]
基于生药对的乌蔹莓果实-合欢子对化学标准化及抗胃黏膜损伤作用研究
Yali Wang,Shuqin Cui,Qi Zhang et al.
Yali Wang et al.
Objectives: The present study sought to elucidate the gastroprotective mechanism of the Akebiae Fructus- Hoveniae Semen combination by integrating chemical fingerprinting, network pharmacology and in vivo validation. ...
Befotertinib restored chemosensitivity to multidrug-resistant cancer cells by inhibiting the drug efflux activity of ABCB1 [0.03%]
贝福替尼通过抑制ABCB1的药物外排活性恢复耐药肿瘤细胞的化学敏感性
Yen-Ching Li,Megumi Murakami,Yang-Hui Huang et al.
Yen-Ching Li et al.
Objectives: Chemotherapy remains central to cancer management, but its effectiveness is often limited by multidrug resistance (MDR), largely mediated by the ATP-binding cassette (ABC) transporter ABCB1 (P-glycoprotein; P-...
From traditional medicine to modern therapeutics: phytochemistry, pharmacology, and innovative sporopollenin-based drug delivery systems of Lycopodium clavatum L [0.03%]
从传统医学到现代治疗学：Lycopodium clavatum L的植物化学、药理及创新孢粉素基药物递送系统
Guohui Shi,Linlin Ni,Xiaoni Kong et al.
Guohui Shi et al.
Objectives: Lycopodium clavatum L. has a long history of use in various traditional medicine systems. This review aims to systematically examine its ethnobotanical applications, phytochemical constituents, and pharmacolog...