In silico designing of palbociclib loaded PLGA long-acting intramuscular injection for palliative therapy of HR+/HER2- metastatic breast cancer
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Objectives: Palbociclib (PBB) is an oral cyclin-dependent kinase 4/6 (CDK4/6) inhibitor approved for the treatment of HR+/HER2- breast cancer. However, poor adherence and limited tolerability of oral administration often compromi... ...
