Amorphous particles enhance oral exposure-a case study of a poorly soluble compound in preclinical, toxicology and early clinical studies [0.03%]
无定形粒子增强口服暴露-一个难溶性药物的药代动力学研究案例分析
Sara Lindblom,Marie Strimfors,Kalle Sigfridsson
Sara Lindblom
Objectives: The aim of this study was to investigate whether different liquid formulations of a selected candidate drug could be utilized to improve oral absorption and subsequent in vivo exposure. ...
Neuroprotective euglobals from Eucalyptus tereticornis Smith. leaves: quantification, network pharmacology-guided in silico analysis, and experimental validation [0.03%]
基于网络药理学的指导模拟分析和实验验证得到的侧膜瓶状果叶中的神经营养剂吴氏环烃：量化、网络药理学指导下的模拟分析及实验验证
Indu Pathania,Akash Kumar Mourya,Aditya Sharma et al.
Indu Pathania et al.
Objectives: This study aims to investigate the neuroprotective potential of terpene-linked phloroglucinol derivatives from Eucalyptus tereticornis leaves. ...
A review of natural plant polysaccharides: the relationship between extraction methods, physicochemical properties, structures, and biological activity [0.03%]
天然植物多糖的研究进展：提取方法、理化性质、结构与生物活性之间的关系
Shoude Zhang,Hedong Jiang,Qieying Jiang et al.
Shoude Zhang et al.
Objectives: The pharmacological activities of plant polysaccharides are closely associated with their unique and complex chemical structures. Extraction, as the initial and critical step in polysaccharide preparation, lar...
Acute intravenous antihypertensive and in vitro vasorelaxant effect of the hydroalcoholic stem bark extract of Hymenaea rubriflora Ducke in spontaneously hypertensive rats [0.03%]
Hymenaea rubriflora Ducke茎皮的水酒精提取物对 SHR急性降压和体外血管松弛作用
Luciana Tavares Toscano,Milton Rocha Moraes,Robson Cavalcante Veras et al.
Luciana Tavares Toscano et al.
Objectives: The cardioprotective potential of Hymenaea rubriflora Ducke's stem bark hydroalcoholic extract (HR-HAc) has not yet been investigated. This study aimed to quantify HR-HAc's antioxidant capacity and evaluate it...
Shanhuang Jiangzhi tablets mitigate atherosclerosis by modulating macrophage polarization and inhibiting foam cell formation via the ROS/TLR4/NF-κB pathway [0.03%]
山黄吉脂片通过调节ROS/Toll样受体4/nuclear factor κB途径抑制泡沫细胞形成及巨噬细胞极化来缓解动脉粥样硬化
Yingwei Chang,Qing Liu,Qixuan Guo et al.
Yingwei Chang et al.
Objectives: Atherosclerosis significantly contributes to global cardiovascular mortality. Macrophage polarization and foam cell formation via oxidized low-density lipoprotein uptake are key drivers of plaque progression a...
Nanocarrier-based targeting strategies in epilepsy: addressing pathophysiological barriers [0.03%]
基于纳米载体的癫痫治疗策略：应对病理生理障碍
Abhishek Chauhan,Ankush Kumar,Ankit Awasthi et al.
Abhishek Chauhan et al.
Objectives: Epilepsy is a chronic neurological disorder affecting nearly 50 million people worldwide and is characterized by recurrent seizures caused by abnormal neuronal activity. Conventional therapies, including antie...
Yuyang Li,Xiaowei Wang,Xinyu Wang et al.
Yuyang Li et al.
Objectives: Targeted protein degradation (TPD) technology, with a particular emphasis on proteolysis-targeting chimeras (PROTAC), has emerged as a pivotal advancement in the field of drug discovery. However, several chall...
The latest developments in oral insulin: scientific advances and clinical progress [0.03%]
口服胰岛素的最新进展：科研突破与临床实践
Hui-Fang Chang,Tzu-Min Lin,Yu-Ling Sun et al.
Hui-Fang Chang et al.
Objectives: Diabetes mellitus remains a global health challenge, with insulin therapy essential for type 1 diabetes and many advanced type 2 cases. However, reliance on subcutaneous injections limits adherence and quality...
Shikonin attenuates platelet activation and thrombosis: a pharmacological evaluation [0.03%]
红花苷抑制血小板活化和血栓形成：药理学评估
Junfeng Guan,Chaonan He,Siqi She et al.
Junfeng Guan et al.
Objectives: Shikonin, a major bioactive naphthoquinone derived from Lithospermum erythrorhizon, exhibits broad pharmacological properties. However, its effects on platelet activation and arterial thrombosis, as well as th...
A GelMA hydrogel co-loaded with resveratrol, 18-β-glycyrrhetinic acid, and berberine for the combination therapy of infected wounds [0.03%]
一种新型胶原膜用于牙周炎局部联合用药治疗的研究
Wenbo Ji,Yaxu Yang,Xinyi Cao et al.
Wenbo Ji et al.
Objectives: To develop a gelatin methacrylate hydrogel dressing loaded with traditional Chinese medicine active components-resveratrol (RES), 18-β-glycyrrhetinic acid (GA), and berberine (BBR)-for the treatment of infect...