Xiao-Lan Yu,Si-Jia Guo,Qi-Rui Cai et al.
Xiao-Lan Yu et al.
Significance: Geraniol (GI), an acyclic monoterpene alcohol, exhibits diverse anti-cancer activities. However, its potential effects against gastric cancer remain poorly understood. ...
Integrating crystal engineering with PEG6000 conjugation to formulate advanced solid dispersions of febuxostat for gout management [0.03%]
Doriana T Ungur,Laura Patras,Mihaela M Pop et al.
Doriana T Ungur et al.
Objectives: Febuxostat (FEB) is a poorly soluble xanthine oxidase inhibitor, which limits its in vitro dissolution performance. This study aimed to enhance the aqueous solubility and dissolution behavior of FEB through cr...
Beta-sitosterol-baicalein-guanosine synergistically alleviates Warburg effect in colorectal cancer via EGFR/ERK pathway [0.03%]
Pingsheng Zhou,Qingci Zeng,Qingling Zhang et al.
Pingsheng Zhou et al.
Objectives: This study investigated whether the active ingredients of Pinellia pedatisecta Schott extract (PE) inhibit colorectal cancer (CRC) by targeting the Warburg effect, a common cancer hallmark, and to elucidate th...
Cryptoxanthin as a multitarget neuroprotective agent: mechanistic and in silico perspectives [0.03%]
Arjun Sadhukhan,Abhishek Chauhan,Mohit Kumar et al.
Arjun Sadhukhan et al.
Objectives: Neurodegenerative diseases such as Parkinson's disease (PD), Huntington's disease (HD), Alzheimer's disease (AD), and Amyotrophic lateral sclerosis (ALS) are complex disorders driven by multiple pathological p...
Allyl isothiocyanate ameliorates collagen-induced arthritis via mast cells and the pim1 pathway [0.03%]
Heng Wang,Yiying Wang,Ronghao Zhang et al.
Heng Wang et al.
Objectives: The present study explored whether allyl isothiocyanate from the traditional Chinese medicine mustard seed, ameliorated the arthritis by modulating immune cell responses, particularly by inhibiting mast cell a...
Protective effects and mechanisms of Panax notoginseng saponins against gp120-induced cognitive impairment: a network pharmacology and metabolomics study [0.03%]
Mingyu Huang,Yijun Zhou,Shan Li et al.
Mingyu Huang et al.
Objective: This study investigates Panax notoginseng saponins (PNS) as a potential treatment for gp120-induced HIV-associated neurocognitive disorder (HAND), in light of the limited efficacy of current therapies. ...
Delonix regia flower extract protects against diabetic cardiac remodeling via modulating eNOS/NO/cGMP and NF-κB/iNOS/TNF-α trajectories [0.03%]
Nadia Hassan,Maged Mohamed,Noura A Hassan et al.
Nadia Hassan et al.
Objectives: This study aimed to elucidate potential mechanisms associated with the cardioprotective efficacy of methanolic Delonix regia extract against the pathophysiological diabetic cardiac remodeling. ...
Xuewei Wu,Litao Chen,Yushan Chen et al.
Xuewei Wu et al.
Objectives: Chemotherapy-induced peripheral neuropathy (CIPN) is a common and serious side effect of cancer treatment. Studies have shown that there is significant sexual dimorphism in animal models, molecular mechanisms ...
Capilliposide from Lysimachia capillipes Hemsl. shows anti-inflammatory and anti-pyretic effects via the MAPK/iNOS/NF-κB pathway [0.03%]
Fanwei Xia,Junyu Zhang,Dongbiao Lu et al.
Fanwei Xia et al.
Objectives: To clarify the antipyretic efficacy of Capilliposide (LC) and investigate its antipyretic mechanism. Methods: Dry yeast was...
In silico designing of palbociclib loaded PLGA long-acting intramuscular injection for palliative therapy of HR+/HER2- metastatic breast cancer [0.03%]
Rutuja Suryawanshi,Anumol Joseph,Rajkumar Malayandi
Rutuja Suryawanshi
Objectives: Palbociclib (PBB) is an oral cyclin-dependent kinase 4/6 (CDK4/6) inhibitor approved for the treatment of HR+/HER2- breast cancer. However, poor adherence and limited tolerability of oral administration often ...