Cinnamon plays a key role in the anti-obesity action of Hachimijiogan by ameliorating leptin resistance in the hypothalamus [0.03%]
肉桂通过改善下丘脑瘦素抵抗在哈仲秘方抗肥胖作用中起关键作用
Syota Kagawa,Katsuya Tanabe,Kakuyou Ogawa et al.
Syota Kagawa et al.
Objectives: Hachimijiogan (MIX8), a traditional herbal formulation comprising eight crude drugs, is used clinically to alleviate symptoms associated with cold conditions. Although anti-obesity effects have been suggested,...
The flavonoids of Trichosanthis Fructus in improving ALI mice based on AUF-MS-SPR [0.03%]
基于AUF-MS-SPR的葫芦籽黄酮改善急性肺损伤小鼠作用机制研究
Cuicui Xu,Qingyu Yan,Hao Kong et al.
Cuicui Xu et al.
Objectives: To investigate the anti-inflammatory mechanism and potential bioactive compounds of the flavonoids of Trichosanthis Fructus (TF) in LPS-induced acute lung injury (ALI) mice. ...
Scutellarin attenuates intestinal epithelial cells pyroptosis in colitis by suppressing P2RX7/NLRP3 signaling pathway [0.03%]
天仙子宁碱通过抑制P2RX7/NLRP3信号通路削弱肠上皮细胞焦亡对肠道的损伤作用
Jie Lu,Kun Liang,Yi Luo et al.
Jie Lu et al.
Objectives: Intestinal epithelial pyroptosis drives intestinal mucosal injury in colitis. Scutellarin, a natural flavonoid, has been reported to exert anti-colitis activity. However, the mechanism by which scutellarin rev...
The context-dependent duality of MEG3: a pivotal regulator and promising target in inflammation-associated diseases [0.03%]
MEG3的炎症相关疾病调控作用及靶点功能研究
Jie-Quan Wang,Tong-Sheng Zhou,Hua Wu et al.
Jie-Quan Wang et al.
Objectives: Chronic inflammation, governed by epigenetic networks, underlies a broad spectrum of diseases. In this context, the long non-coding RNA maternally expressed gene 3 (MEG3) has emerged as a pivotal molecular nod...
Insulin resistance and asthma: from pathogenic pathways to therapeutic opportunities [0.03%]
胰岛素抵抗和哮喘：从发病机制到治疗机遇
Arwa M Amin,Hamza Mostafa
Arwa M Amin
Background: Asthma is a chronic respiratory disease with a significant global burden. Several risk factors interact to contribute to the development of asthma. Large cross-sectional and longitudinal studies highlight a ro...
Amorphous particles enhance oral exposure-a case study of a poorly soluble compound in preclinical, toxicology and early clinical studies [0.03%]
无定形粒子增强口服暴露-一个难溶性药物的药代动力学研究案例分析
Sara Lindblom,Marie Strimfors,Kalle Sigfridsson
Sara Lindblom
Objectives: The aim of this study was to investigate whether different liquid formulations of a selected candidate drug could be utilized to improve oral absorption and subsequent in vivo exposure. ...
Neuroprotective euglobals from Eucalyptus tereticornis Smith. leaves: quantification, network pharmacology-guided in silico analysis, and experimental validation [0.03%]
基于网络药理学的指导模拟分析和实验验证得到的侧膜瓶状果叶中的神经营养剂吴氏环烃：量化、网络药理学指导下的模拟分析及实验验证
Indu Pathania,Akash Kumar Mourya,Aditya Sharma et al.
Indu Pathania et al.
Objectives: This study aims to investigate the neuroprotective potential of terpene-linked phloroglucinol derivatives from Eucalyptus tereticornis leaves. ...
A review of natural plant polysaccharides: the relationship between extraction methods, physicochemical properties, structures, and biological activity [0.03%]
天然植物多糖的研究进展：提取方法、理化性质、结构与生物活性之间的关系
Shoude Zhang,Hedong Jiang,Qieying Jiang et al.
Shoude Zhang et al.
Objectives: The pharmacological activities of plant polysaccharides are closely associated with their unique and complex chemical structures. Extraction, as the initial and critical step in polysaccharide preparation, lar...
Acute intravenous antihypertensive and in vitro vasorelaxant effect of the hydroalcoholic stem bark extract of Hymenaea rubriflora Ducke in spontaneously hypertensive rats [0.03%]
Hymenaea rubriflora Ducke茎皮的水酒精提取物对 SHR急性降压和体外血管松弛作用
Luciana Tavares Toscano,Milton Rocha Moraes,Robson Cavalcante Veras et al.
Luciana Tavares Toscano et al.
Objectives: The cardioprotective potential of Hymenaea rubriflora Ducke's stem bark hydroalcoholic extract (HR-HAc) has not yet been investigated. This study aimed to quantify HR-HAc's antioxidant capacity and evaluate it...
Shanhuang Jiangzhi tablets mitigate atherosclerosis by modulating macrophage polarization and inhibiting foam cell formation via the ROS/TLR4/NF-κB pathway [0.03%]
山黄吉脂片通过调节ROS/Toll样受体4/nuclear factor κB途径抑制泡沫细胞形成及巨噬细胞极化来缓解动脉粥样硬化
Yingwei Chang,Qing Liu,Qixuan Guo et al.
Yingwei Chang et al.
Objectives: Atherosclerosis significantly contributes to global cardiovascular mortality. Macrophage polarization and foam cell formation via oxidized low-density lipoprotein uptake are key drivers of plaque progression a...