Rosavin and salidroside attenuate microglia injury via nuclear factor κ-B signaling pathway [0.03%]
玫瑰石竹提取物 rosavin 和 salidroside 通过调节核转录因子 κ-B 调节微胶质细胞损伤作用研究
Hang Liu,Yandong Ma,Qian Chen et al.
Hang Liu et al.
Objectives: Inflammation, oxidative harm, and degradation of mitochondria ultimately contribute to the initiation neurodegenerative changes. This study investigated the inhibitory effects of rosavin and salidroside on neu...
Key signalling pathways in head and neck squamous cell carcinoma: mechanisms and therapeutic targets [0.03%]
头颈鳞癌关键信号转导通路：机制和治疗靶点
Enas Bani-Ahmad,Joshua Dass,Crispin R Dass
Enas Bani-Ahmad
Objectives: This review examines the signalling pathways involved in head and neck cancer cell survival and apoptosis. Methods: Article...
Challenges and innovations in long-acting injectable formulations: can formulation design space be rationalized? [0.03%]
长效注射剂的挑战与创新：制剂设计空间可以理性化吗？
Andrew Otte,Kinam Park,Tonglei Li
Andrew Otte
Objectives: To date, ~70 long-acting injectable (LAI) formulations have been developed. More than half of these formulations consist of oily solutions and suspensions containing poorly water-soluble drugs. However, numero...
Oleanolic acid attenuates cardiac hypertrophy by improving endothelial mitochondrial function and inhibiting pyroptosis [0.03%]
五味子醇通过改善内皮细胞线粒体功能和抑制焦亡来缓解心脏肥大
Xiaolei Li,Jing Wu,Bo Lin et al.
Xiaolei Li et al.
Purpose: Cardiac microvascular impairment serves a function in cardiac hypertrophy (CH). Oleanolic acid (OA), a bioactive pentacyclic triterpenoid substance, has been extensively investigated for its anti-inflammatory and...
Additive cardioprotection by dapagliflozin and pioglitazone co-therapy in streptozotocin-induced diabetic rats [0.03%]
在链脲佐菌素致糖尿病大鼠中达格列净和吡格列酮联用的附加心脏保护作用
Eva Kralova,Aneta Cinakova,Jan Klimas et al.
Eva Kralova et al.
Objectives: In diabetes mellitus, inflammation and apoptosis contribute to cardiovascular injury and oxidative damage. Dapagliflozin and Pio, beyond their hypoglycemic effects, mitigate organ damage. This study explored w...
Yinxu Wang,Qian Wen,Anli Hu et al.
Yinxu Wang et al.
Objectives: The primary objective of this review is to summarize research cases and recent advances in ultrasound technology for overcoming the blood-brain barrier (BBB) and facilitating drug delivery to the brain, thereb...
Screening adsorbents for the prevention of drug-induced intestinal dysbiosis at pre-formulation stage: case example activated charcoal [0.03%]
一种药物诱导的肠道菌群紊乱筛选吸附剂的方法：活性炭案例分析
Lea Gnatzy,Dimitrios-Marios Katsikis,Konstantinos Papandreou et al.
Lea Gnatzy et al.
Objectives: Develop a biorelevant in vitro methodology to screen adsorbents for their safety and for their efficacy to remove unabsorbed drugs from the colonic lumen using activated charcoal (AC) as a model adsorbent; Eva...
Cyclodextrin-based formulations for pediatric patients: pharmaceutical prospectives and toxicological evaluation [0.03%]
基于环糊精的儿童患者给药体系：药学前景和毒理学评价
Theingi Tun,Hay Marn Hnin,Vu Minh Triet et al.
Theingi Tun et al.
Pediatric drug development faces significant challenges due to age-specific physiological differences, with limited approved formulations often resulting in off-label or extemporaneous uses. Oral administration remains the most common route...
Design and optimization of carvedilol-loaded transbilosomes for the control of diabetic high-fat diet-induced atherosclerosis in rats [0.03%]
一种用于控制糖尿病高脂饮食诱导的实验性大鼠动脉粥样硬化的卡维地洛载药转胞膜囊泡的设计及优化研究
Marwa M Nagib,Ala Hussain Haider,Amr Gamal Fouad et al.
Marwa M Nagib et al.
Objectives: Carvedilol (CDL) is an oral beta-adrenergic blocker known for enhancing arterial blood flow and reducing hyperglycemia due to its antioxidant properties. However, CDL's short half-life leads to its low efficac...
Chanjuan Zhao,Xingan Yan,Dongguo Zhu et al.
Chanjuan Zhao et al.
Respiratory infectious diseases caused by viruses pose a serious threat to human and animal health. In the search for effective antiviral agents, natural polysaccharides have emerged as promising candidates with significant potential. As na...