Neutrophil/lymphocyte ratio and lymphocyte/monocyte ratio in ulcerative colitis as non-invasive biomarkers of disease activity and severity [0.03%]
中性粒细胞/淋巴细胞比值和淋巴细胞/单核细胞比值作为溃疡性结肠炎的非侵入性疾病活动性和严重程度生物标志物的能力
Ashraf M Okba,Mariam M Amin,Ahmed S Abdelmoaty et al.
Ashraf M Okba et al.
Background: Apart from endoscopic interventions, readily attainable cost-effective biomarkers for ulcerative colitis (UC) assessment are required. For this purpose, we evaluated differential leucocytic ratio, mainly neutr...
Anti-β2-glycoprotein I and anti-phosphatidylserine/prothrombin antibodies exert similar pro-thrombotic effects in peripheral blood monocytes and endothelial cells [0.03%]
抗β2糖蛋白I和抗磷脂/凝血酶原抗体在周边单核白血球与血管内皮细胞中产生类似的促栓作用
A Cifù,R Domenis,C Pistis et al.
A Cifù et al.
Purpose: The introduction of the anti-phosphatidylserine/prothrombin (aPS/PT) antibodies among the routinely investigated anti-phospholipid (aPL) antibodies led to an improvement in anti-phospholipid syndrome (APS) labora...
The search for the Holy Grail: autoantigenic targets in primary sclerosing cholangitis associated with disease phenotype and neoplasia [0.03%]
寻找圣杯：与原发性硬化性胆管炎疾病表型和肿瘤相关自身抗原抗体靶点的探索
Steffi Lopens,Marcin Krawczyk,Maria Papp et al.
Steffi Lopens et al.
Unlike in other autoimmune liver diseases such as autoimmune hepatitis and primary biliary cholangitis, the role and nature of autoantigenic targets in primary sclerosing cholangitis (PSC), a progressive, chronic, immune-mediated, life thre...
Renato Tozzoli
Renato Tozzoli
Receptor autoimmunity is one of the ways in which autoimmune diseases appear in humans. Graves' disease, myasthenia gravis, idiopathic membranous nephropathy, and autoimmune acute encephalitis are the major autoimmune diseases belonging to ...
Anti-domain 1 β2 glycoprotein antibodies increase expression of tissue factor on monocytes and activate NK Cells and CD8+ cells in vitro [0.03%]
抗域1β2糖蛋白抗体增加单核细胞中组织因子的表达并激活体外NK细胞和CD8+细胞
Gayane Manukyan,Anush Martirosyan,Ludek Slavik et al.
Gayane Manukyan et al.
Background: β2-Glycoprotein I (β2GPI) represents the major antigenic target for antiphospholipid antibodies (aPL), with domain 1 (D1) being identified as a risk factor for thrombosis and pregnancy complications in APS. ...
Associations between HLA and autoimmune neurological diseases with autoantibodies [0.03%]
自身免疫性脑炎的HLA相关性研究进展
Sergio Muñiz-Castrillo,Alberto Vogrig,Jérôme Honnorat
Sergio Muñiz-Castrillo
Recently, several autoimmune neurological diseases have been defined by the presence of autoantibodies against different antigens of the nervous system. These autoantibodies have been demonstrated to be specific and useful biomarkers, and m...
Twenty years of research on the DFS70/LEDGF autoantibody-autoantigen system: many lessons learned but still many questions [0.03%]
关于DFS70/LEDGF自身抗体-抗原系统研究的二十年进展：已收获颇多，但仍有许多亟待解决的问题
Greisha L Ortiz-Hernandez,Evelyn S Sanchez-Hernandez,Carlos A Casiano
Greisha L Ortiz-Hernandez
The discovery and initial characterization 20 years ago of antinuclear autoantibodies (ANAs) presenting a dense fine speckled (DFS) nuclear pattern with strong staining of mitotic chromosomes, detected by indirect immunofluorescence assay i...
The perspective on standardisation and harmonisation: the viewpoint of the EASI president [0.03%]
标准制定与协调的视角:EASI会长观点
Jan Damoiseaux
Jan Damoiseaux
Standardisation of immuno-assays for autoantibodies is a major challenge. Although multiple organisations participate in the generation of internationally accepted standards, adequate standardisation of assays has not yet been achieved. Har...
Association of HLA-B27 and Behcet's disease: a systematic review and meta-analysis [0.03%]
HLA-B27与贝赫切特病关联的系统评价和Meta分析
Alireza Khabbazi,Leila Vahedi,Morteza Ghojazadeh et al.
Alireza Khabbazi et al.
Background: To calculate the genetic impact of the "HLA-B27" allele on the risk of Behcet's disease (BD) progression using a systematic review and meta-analysis on case control papers. ...
Protective effect of TSLP and IL-33 cytokines in ulcerative colitis [0.03%]
TSLP和IL-33细胞因子在溃疡性结肠炎中的保护作用
Sahar Tahaghoghi-Hajghorbani,Abolghasem Ajami,Saeedeh Ghorbanalipoor et al.
Sahar Tahaghoghi-Hajghorbani et al.
Purpose: Inflammatory bowel disease (IBD) primarily includes ulcerative colitis (UC) and Crohn's disease (CD). Thymic stromal lymphopoietin (TSLP) is a cytokine produced by intestinal epithelial cells (IECs) with immunomo...