Regulatory Signaling Pathways in Ovarian Cancer Stem Cells: Their Role in Tumor Progression and Therapeutic Strategies [0.03%]
卵巢癌干细胞中的调控信号转导通路及其在肿瘤发生发展和治疗策略中作用的研究进展
Dini Amalia,Febriani Febriani,Arfianti Arfianti
Dini Amalia
In ovarian cancer, ovarian cancer stem cells (OCSCs) not only contribute to tumor formation but also drive the progression, metastasis, and chemoresistance. The defining properties of OCSCs are sustained through the Wnt/β-catenin, Notch, a...
Genetically Engineered Probiotics: Design, Therapeutics, and Clinical Translation [0.03%]
基因工程益生菌：设计、治疗和临床转化
Mahsa Boogari,Maryam Mohebbi,Naghmeh Hadidi
Mahsa Boogari
Genetically engineered probiotics aim to address transient colonization and the intra- and inter-subject variability that limit conventional probiotics. These strains utilizes CRISPR/Cas editing, programmable gene circuits, and biosensors i...
Novel FKBP10 Mutation in Iranian Patients with Osteogenesis Imperfecta: Insights from Whole-Exome Sequencing to Molecular Dynamics [0.03%]
伊朗OI患者的新型FKBP10突变：从外显子组测序到分子动力学的见解
Moslem Hoseinbeyki,Shirin Moradifard,Fatemeh Mirkhani et al.
Moslem Hoseinbeyki et al.
Background: Osteogenesis imperfecta (OI) is a rare hereditary disorder affecting bone and connective tissue. While most cases are linked to autosomal dominant mutations in the COL1A1 and COL1A2 genes, FKBP10 variants are ...
Liquid Biopsy for EGFR Mutation Detection in NSCLC: Evaluation of Plasma ctDNA and Comparison with Plasma exoDNA [0.03%]
肺癌组织液活检EGFR突变检测：血浆ctDNA与外泌体DNA的比较研究
Parisa Mashayekhi,Mir Davood Omrani,Ali Dehghanifard et al.
Parisa Mashayekhi et al.
Background: Accurate detection of actionable EGFR mutations is essential for guiding targeted therapy in NSCLC. Liquid biopsy approaches using ctDNA and exoDNA offer noninvasive alternatives for molecular profiling. This ...
Observational Study
Iranian biomedical journal. 2025 Oct 28. DOI:10.61882/ibj.5018 2025
Genome-Scale Metabolic Modeling Identifies Synergistic Metabolites that Enhance 5-Fluorouracil Efficacy in Colon Cancer [0.03%]
基于基因组范围的代谢建模鉴定出可增强5-氟尿嘧啶对结肠癌疗效的协同代谢物
Hasan Rahimi-Tamandegani,Ayed-Amir Marashi,Ghazaleh Ghavami et al.
Hasan Rahimi-Tamandegani et al.
Background: Colon cancer remains a leading cause of cancer-related mortality, with the efficacy of standard chemotherapy agents such as 5-FU limited by resistance and toxicity. This study aimed to identify metabolites tha...
Persian Medicinal Plants as Antidiabetic Agents: Mechanisms and Evidence from Bench to Bedside [0.03%]
波斯药用植物作为抗糖尿病制剂的机制和证据：从实验到临床
Hasan Fallah Huseini,Masoud Haghighi,Saeed Kianbakht et al.
Hasan Fallah Huseini et al.
The use of medicinal plants by diabetic patients dates back to ancient times. In recent years, numerous reports have been published on the efficacy and safety of many medicinal plants in the treatment of diabetes through various mechanisms....
Reno-Protective Properties of Azolla pinnata Extract Against Gentamicin-Induced Kidney Damage Are Attributed to Its Antioxidant Effects [0.03%]
轮叶雨蛙藻提取物对抗生素庆大霉素所致肾脏损伤的肾保护作用归功于其抗氧化效应
Mohammad Ghanbari Alamoti,Farideh Jalali Mashayekhi,Naser Hosseini et al.
Mohammad Ghanbari Alamoti et al.
Background: Gentamicin (GM), a powerful aminoglycoside antibiotic, is limited in clinical use due to dose-related kidney toxicity, mainly caused by oxidative stress. Azolla pinnata, an antioxidant-rich aquatic fern, has n...
Alterations in the Expression of miR-148a-5p, TGF-β1, and TGF-βR2 in Skin Samples Exposed to Sulfur Mustard [0.03%]
芥子气暴露皮肤组织中miR-148a-5p、TGF-β1及TGF-βR2表达水平的变化
Atiyeh Tavakoli,Saeed HHeidari Keshel,Mohades Valizadeh
Atiyeh Tavakoli
Background: Sulfur mustard (SM) exposure causes chronic cutaneous injuries characterized by inflammation, fibrosis, and delayed wound healing. MiRNAs, such as miR-148a-5p, have been implicated in regulating the Transformi...
Helicobacter pylori Dihydroorotate Dehydrogenase: a Promising Target for Screening Potential Drug Candidates [0.03%]
幽门螺旋杆菌二氢乳清酸脱氢酶：筛选潜在药物候选物的良好靶点
Saba Ghaffari,Maryam Esmaeili,Fatemeh Ayoubnejad et al.
Saba Ghaffari et al.
Background: De novo pyrimidine biosynthesis is essential for the survival of all living organisms. Dihydroorotate dehydrogenase (DHODH) catalyzes the fourth step in this pathway. Inhibition of DHODH induces pyrimidine dep...
Chloroquine Enhances Mda-7- Induced Apoptosis via miR-7 and HSP70 Modulation in Glioblastoma [0.03%]
氯喹通过调节胶质母细胞瘤中的miR-7和HSP70增强MDA-7诱导的细胞凋亡作用
Seyedeh Maliheh Babazadeh,Mohammad Reza Zolfaghari,Mohsen Zargar et al.
Seyedeh Maliheh Babazadeh et al.
Background: Melanoma differentiation-associated gene-7 (Mda-7) selectively suppresses growth and induces apoptosis in various tumor cells without harming normal cells. Inhibition of autophagy has been shown to enhance the...