Helicobacter pylori Dihydroorotate Dehydrogenase: a Promising Target for Screening Potential Drug Candidates
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Background: De novo pyrimidine biosynthesis is essential for the survival of all living organisms. Dihydroorotate dehydrogenase (DHODH) catalyzes the fourth step in this pathway. Inhibition of DHODH induces pyrimidine depletion a... ...
