Cannabidiol attenuates lung ischemia-reperfusion injury by modulating RIPK1/RIPK3-mediated necroptosis and HIF-1α/VEGF signaling [0.03%]
大麻二酚通过调节RIPK1 / RIPK3介导的坏死性凋亡和HIF-1α / VEGF信号来减轻肺缺血再灌注损伤
Hasan Ekrem Camas,Mehtap Savran,Serap Yildirim et al.
Hasan Ekrem Camas et al.
Objectives: Lung ischemia-reperfusion (IR) injury is a critical clinical condition characterized by oxidative stress, inflammation, and necroptosis, often leading to severe complications. Cannabidiol (CBD), a non-psychoac...
Protective effects and mechanism of chrysophanol against age-related osteoporosis in rats [0.03%]
大黄素对衰老模型小鼠的骨保护作用及机制研究
Qing Lu,Chenxi Zhang,Lixia Ma et al.
Qing Lu et al.
Objectives: This study aimed to investigate the protective effect and underlying mechanism of chrysophanol (CPH) on senile osteoporosis (OP) in rats. Mate...
HIPK2 protects neurons from oxidative stress and modulates central nervous system responses following traumatic brain injury [0.03%]
HIPK2保护神经元免受氧化应激并在脑创伤后调节中枢神经系统反应
Qiangbin Zhu,Fan Wang,Bojun Zhang et al.
Qiangbin Zhu et al.
Objectives: Traumatic brain injury (TBI) induces oxidative stress, contributing to secondary neuronal damage. This study aimed to elucidate the role of the stress-responsive kinase HIPK2 in regulating endogenous antioxida...
Recent advances in the detection and treatment of hydatid cysts by nanomaterial-based carriers [0.03%]
基于纳米材料的载药体系在棘球蚴病检测与治疗领域的新进展
Nozhat Zebardast,Farid Ajori,Rahim Nosrati
Nozhat Zebardast
Cystic echinococcosis (CE) is a neglected parasitic disease. Although several therapeutic approaches are available for CE, including PAIR (Puncture, Aspiration, Injection, Re-aspiration), surgery, chemotherapy with anthelmintic drugs, and w...
Repurposing an antimicrobial arginine-rich decapeptide as a novel anticancer agent: Evidence from in vitro and in vivo breast cancer models [0.03%]
一种抗菌精氨癸肽作为抗肿瘤药物治疗乳腺癌的研究
Reyhane Chamani,Maryam Mohammadi
Reyhane Chamani
Objectives: Arginine-rich peptides have attracted interest because of their ability to interact with negatively charged cancer cell membranes. The present study aimed to evaluate the anticancer properties of a novel antim...
Targeting amyloid-β in Alzheimer's disease: A critical analysis of clinical trials and their implications for drug development [0.03%]
阿尔茨海默病抗淀粉样蛋白治疗临床试验的批判性分析及其对药物研发的影响
Mengyu Han,Zhonghua Li,Tiancheng Sun et al.
Mengyu Han et al.
Alzheimer's disease (AD), a prevalent neurodegenerative dementia, is characterized by amyloid-β (Aβ) plaques and neurofibrillary tangles, with Aβ playing a central pathogenic role. Approved AD drugs, primarily acetylcholinesterase inhibi...
Ultrasound medicine in the era of precision theranostics: Mechanisms, molecular strategies, and clinical translation [0.03%]
精准诊疗时代的超声医学：机制、分子策略与临床转化
Lei Wang,Zhiyu Luo,Dan Liu
Lei Wang
Ultrasound (US) has evolved from a solely diagnostic tool into a multifaceted theranostics platform, proficient in both high-resolution imaging and tailored therapeutic intervention. Progress in acoustic physics, microbubble and nanobubble ...
Characterization of exosomes from hypoxia-activated human amniotic membrane mesenchymal stem cells [0.03%]
低氧诱导的人胎盘间充质干细胞外泌体的表征研究
Hadiseh Kholgh,Fatemeh Eshghabadi,Hanieh Jafary et al.
Hadiseh Kholgh et al.
Objectives: Hypoxia is a physical stimulus that enhances stem cell activities to produce more cellular derivatives, particularly exosomes. Enhancing the quantity and quality of exosomes can improve their therapeutic prope...
Impact of TGF-β and ERK1/2 inhibition on preimplantation embryo development and quality [0.03%]
TGF-β和ERK1/2抑制对胚胎体外发育和质量的影响
Faezeh Mohammadi Ghazani,Fatemeh Shirvanizadeh,Seyedeh-Nafiseh Hassani et al.
Faezeh Mohammadi Ghazani et al.
Objectives: Preimplantation embryo culture is a critical phase in assisted reproductive technologies. The use of small molecules to modulate signaling pathways has emerged as a strategy to improve embryo viability. SB4315...
Trans sodium crocetinate protects against hepatotoxicity induced by bisphenol A in rats [0.03%]
trans-钠盐番红素对抗双酚A致肝毒性作用
Majid Keshavarzi,Bibi Marjan Razavi,Hossein Hosseinzadeh
Majid Keshavarzi
Objectives: Bisphenol A (BPA) is a monomer used in producing a wide range of materials and products, and it is recognized as an endocrine disruptor. Exposure to BPA can cause toxicity in multiple organs, especially the li...