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Targeting amyloid-β in Alzheimer's disease: A critical analysis of clinical trials and their implications for drug development

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Alzheimer's disease (AD), a prevalent neurodegenerative dementia, is characterized by amyloid-β (Aβ) plaques and neurofibrillary tangles, with Aβ playing a central pathogenic role. Approved AD drugs, primarily acetylcholinesterase inhibitors, only alleviat... ...