CD73 blockade alleviates collagen-induced arthritis by inhibiting synovial fibroblast activity [0.03%]
CD73阻断通过抑制滑膜纤维母细胞活性缓解胶原诱导的关节炎
Xia-Nan Wu,Rui-Cheng Li,Ruo-Xuan Hei et al.
Xia-Nan Wu et al.
Objectives: Rheumatoid arthritis (RA) is a chronic autoimmune disease with progressive cartilage erosion and joint destruction. CD73 plays a critical role in regulating inflammatory responses. This study aims to investiga...
Huy Dinh Vu,Huynh Thi Ngoc Ni,Tran Thi Thanh Thuy et al.
Huy Dinh Vu et al.
Kurarinone (KRN) is a major prenylated flavanone isolated from Sophora flavescens, widely recognized for its diverse pharmacological activities and growing therapeutic relevance. This review provides a comprehensive and updated overview of ...
Mitigation of sepsis-associated acute kidney injury by thymoquinone via targeting pyroptosis and attenuation of inflammation in C57BL/6 mice [0.03%]
通过靶向吡咯烷和减缓炎症来缓解C57BL/6小鼠脓毒症相关急性肾损伤的细胞质型二氢杨梅素的作用机制研究 thymoquinone
Niloofar Izadi,Mahdieh Taheri,Mehrdad Roghani
Niloofar Izadi
Objectives: Acute kidney injury (AKI) is a severe, life-threatening complication of sepsis that often leads to renal failure. Thymoquinone, the main bioactive component of Nigella sativa, exhibits potent antioxidant and a...
Quercetin improves ESAT-6-induced pleural mesothelial cell fibrosis by activating the Nrf2/HO-1 pathway [0.03%]
槲皮素通过激活Nrf2/HO-1信号途径改善ESAT-6诱导的胸膜间皮细胞纤维化效应
Lina Chen,Zhou Yu,Zhuo Zhou et al.
Lina Chen et al.
Objectives: This study investigated the mechanism by which quercetin suppresses oxidative stress and improves fibrosis in human pleural mesothelial cells (HPMCs) induced by the Mycobacterium tuberculosis-specific antigen ...
Rosa damascena in exercise-induced neuroinflammation and recovery: A narrative review bridging traditional medicine and translational sports science [0.03%]
玫瑰香茅在运动诱导的神经炎症和恢复中的作用：一篇连接传统医学与转化体育科学的叙述性评论文章
Babak Hooshmand-Moghadam,Abbas Ali Gaeini
Babak Hooshmand-Moghadam
Rosa damascena (Damask rose) has long been esteemed in traditional medicine for its neurocalming, anti-inflammatory, and antioxidant properties. Recent scientific interest highlights its potential to address exercise-induced physiological a...
Transforming PRP into a shelf-stable therapy: Lyophilization preserves angiogenic and regenerative properties [0.03%]
将PRP转化为可长期保存的疗法：冻干法能够保持其促血管生成和再生的特性
Amin Solouki,Tahereh Manoochehrabadi,Mohammad Hossein Mohammadi et al.
Amin Solouki et al.
Objectives: Platelet-rich plasma (PRP) is widely used in regenerative medicine due to its high concentration of bioactive growth factors; however, its short shelf life limits its clinical applicability. Lyophilization has...
Digital immune twins and ai-integrated multi-omic biomarkers: Redefining personalized immunotherapy in non-small cell lung cancer [0.03%]
数字免疫孪生和AI集成多组学生物标志物：重新定义非小细胞肺癌的个性化免疫治疗
Qamar Abuhassan,Hamzeh Jamal Al-Ameer,Zoltan Balogh et al.
Qamar Abuhassan et al.
Non-small cell lung cancer (NSCLC) remains one of the leading causes of global cancer mortality despite advances in immunotherapy. While immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis have transformed clinical outcomes fo...
Combining sorafenib and Lactobacillus rhamnosus GG reduces liver fibrosis and hepatic encephalopathy following bile duct ligation in rats [0.03%]
鼠乳梨形杆菌GG联合索拉非尼减少胆管结扎大鼠肝纤维化和肝性脑病
Tina Rahjoo,Ghorbangol Ashabi,Soheila Adeli et al.
Tina Rahjoo et al.
Objectives: Liver fibrosis can progress to hepatic encephalopathy (HE). While sorafenib is a drug employed to treat liver fibrosis, its use is linked to drug resistance and adverse effects. We examined the potential benef...
Inhibition of the PKC-TRPV1-SP axis by propolis ameliorates chronic inflammatory pain in mice [0.03%]
通过茋胶抑制PKC-TRPV1-SP轴可缓解小鼠慢性炎症痛
Jiayi Yu,Siyuan Yin,Hui Chen et al.
Jiayi Yu et al.
Objectives: Chronic inflammatory pain significantly affects patient quality of life; however, existing treatment methods have limitations. Propolis is rich in various bioactive ingredients, such as flavonoids and phenolic...
Eugenol attenuates paclitaxel-induced cardiotoxicity by modulating autophagy-related markers in rats [0.03%]
丁香酚通过调节大鼠自噬相关标志物减轻紫杉醇诱导的心脏毒性
Halime Tozak Yildiz,Sadık Küçükgünay,Oya Korkmaz et al.
Halime Tozak Yildiz et al.
Objectives: Paclitaxel (PTX) is a commonly used chemotherapeutic agent that causes cardiotoxicity characterized by oxidative stress, inflammation, and mitochondrial dysfunction, which disrupts autophagy and apoptosis in c...