Intranasal Delivery of Bacterial Extracellular Vesicles Enables RNA Cargo Entry Into the Brain [0.03%]
鼻内给药的细菌胞外囊泡使RNA货物进入大脑
Jae Yeong Ha,So-Mi Kim,Song-Yi Choi et al.
Jae Yeong Ha et al.
Extracellular vesicles (EVs) released by bacteria are potent mediators of host-microbe interactions. They modulate immune responses, deliver functional molecules and influence disease progression. However, whether bacterial EVs can access t...
Targeted Delivery of mRNA to the Heart via Extracellular Vesicles or Lipid Nanoparticles [0.03%]
通过细胞外囊泡或脂质纳米颗粒靶向递送mRNA至心脏
Muhammad Nawaz,Benyapa Tangruksa,Sepideh Heydarkhan-Hagvall et al.
Muhammad Nawaz et al.
Efficient and specific delivery of mRNA to target tissues is critical for maximising therapeutic benefits while minimising off-target effects and systemic toxicity. Systemic administration of mRNA using lipid nanoparticles (LNPs) or extrace...
Heparanase-Loaded CAR T Extracellular Vesicles Remodel the Colorectal Tumour Microenvironment and Boost T Cell Antitumor Immunity [0.03%]
装载有肝素酶的CAR-T源外泌体重塑肿瘤微环境并促进T细胞抗肿瘤免疫能力
Songshan Zhu,Jun Yin,Weiqiang Yang et al.
Songshan Zhu et al.
Chimeric antigen receptor (CAR) T cell therapy has shown promise in solid tumours, but its efficacy is limited by dense extracellular matrix (ECM) that blocks T cell entry. We engineered mesothelin-targeted CAR T cells to express heparanase...
Tumour-Derived Extracellular Vesicles Induce Diffuse Large B-Cell Lymphoma Progression Through Macrophage-Mediated MDSC Accumulation [0.03%]
肿瘤来源的细胞外囊泡通过巨噬细胞介导的MDSC积聚诱导弥漫性大B细胞淋巴瘤进展
Mengke Liu,YingYu Dong,Qixiao Guan et al.
Mengke Liu et al.
Elevated peripheral myeloid-derived suppressor cells (MDSCs) predicted suppressed anti-tumour immunity and poor prognosis in diffuse large B-cell lymphoma (DLBCL) patients. Here we demonstrated that tumour-derived extracellular vesicles (EV...
RNAs Associated With Bacterial Outer Membrane Vesicles: Structural Insights Into Surface Composition [0.03%]
细菌外膜囊泡相关RNA：表面组成结构洞察
Kevin Mosca,Florian Turbant,Wafa Achouak et al.
Kevin Mosca et al.
Gram-negative bacteria release outer membrane vesicles (OMVs) that deliver various molecules, including virulence factors, allowing them to interact with their host. Recent evidence suggests that OMVs may serve as carriers for RNAs, in part...
Engineered Pericyte-Targeted Extracellular Vesicles Protect Against Hypoperfusion-Induced Cognitive Impairment and Vascular Demyelination [0.03%]
工程化血管周细胞靶向细胞外囊泡可防止低灌注引起的认知障碍和脱髓鞘病变
Weiwei Shen,Weishi Liu,Min Guo et al.
Weiwei Shen et al.
Pericyte dysfunction is an early hallmark of vascular cognitive impairment (VCI), yet targeted therapies remain limited. Here, we develop a bio-orthogonal approach to engineer extracellular vesicles (EVs) functionalized with cyclic NGR (cNG...
Tumour-Derived Extracellular Vesicles Reprogramme Tumour-Associated Macrophages Into Immunosuppressive Phenotype via NOD1 Signalling in Clear Cell Renal Cell Carcinoma [0.03%]
透明细胞肾细胞癌来源的肿瘤微环境中，NOD1信号介导的外泌体极化肿瘤相关巨噬细胞向免疫抑制表型转换的作用及机制研究
Xiu-Wu Pan,Mu-Chen Li,Tian-Yue Yang et al.
Xiu-Wu Pan et al.
Clear cell renal cell carcinoma (ccRCC)-derived extracellular vesicles (EVs) play a pivotal role in myeloid cell differentiation toward immunosuppressive phenotypes, yet the underlying mechanisms remain poorly understood. Through integrated...
Surface N-Glycosylation Dictates MSC-EV Uptake and CCR2-Driven Monocyte Recruitment to Inflamed Endothelium Under Shear Flow [0.03%]
细胞表面N-连接聚糖决定间充质干细胞外泌体摄取及单核细胞募集参与血管内皮炎症反应
Marta Clos-Sansalvador,Marta Monguió-Tortajada,Sergio G Garcia et al.
Marta Clos-Sansalvador et al.
Mesenchymal stromal cell-derived extracellular vesicles (MSC-EV) hold promising potential for immunomodulation and tissue regeneration, especially for treating ischemia-reperfusion injury (IRI). However, their therapeutic use is hindered by...
Cell Membrane Vesicles Encapsulating Il24 mRNA With Enriched CD6 Display Exhibit Enhanced Targeted Antitumor Efficacy [0.03%]
包裹IL24 mRNA并富集CD6展示的细胞膜囊泡具有增强的靶向抗肿瘤功效
Dandan Wang,Ruofan Gao,Duo Liu et al.
Dandan Wang et al.
mRNA-based therapeutics offer significant potential for cancer treatment owing to their ability to induce transient, non-integrating expression of therapeutic proteins. However, effective and tumour-specific delivery remains a major barrier...
Correction to "Glycoengineered extracellular vesicles released from antibacterial hydrogel facilitate diabetic wound healing by promoting angiogenesis" [0.03%]
题为“抗菌水凝胶释放的糖工程化细胞外囊泡通过促进血管生成加速糖尿病伤口愈合”的更正通知
Published Erratum
Journal of extracellular vesicles. 2026 Jun;15(6):e70314. DOI:10.1002/jev2.70314 2026