Heparanase-Loaded CAR T Extracellular Vesicles Remodel the Colorectal Tumour Microenvironment and Boost T Cell Antitumor Immunity
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Chimeric antigen receptor (CAR) T cell therapy has shown promise in solid tumours, but its efficacy is limited by dense extracellular matrix (ECM) that blocks T cell entry. We engineered mesothelin-targeted CAR T cells to express heparanase (HPSE) fused to the... ...
