NF1 Leucine Rich Domain-Derived Extracellular Vesicles Remodel the Glioblastoma Immune Microenvironment via an ADAM17-Associated Inflammatory Program [0.03%]
通过ADAM17相关炎症程序重塑胶质母细胞瘤免疫微环境的NF1亮氨酸丰富结构域衍生的细胞外囊泡
Yuganthini Vijayanathan,Jacqueline Yt Yeo,Janice Hy Tan et al.
Yuganthini Vijayanathan et al.
Extracellular vesicles (EVs) are increasingly recognized as mediators of intercellular communication in cancer. We previously demonstrated that re-expression of the leucine-rich domain (LRD) of neurofibromin (NF1) suppresses glioblastoma (G...
Regulatory Science of Extracellular Vesicles: From ISEV Standards to Translational Implementation (Insights From Japan) [0.03%]
从ISEV标准到转化实施：日本外泌体监管科学的见解
Yusuke Yoshioka,Yu Fujita,Takahiro Ochiya
Yusuke Yoshioka
Extracellular vesicles (EVs) offer compelling opportunities for diagnostics and therapeutics, yet translation toward routine clinical use and commercial readiness remains limited. In diagnostics, EV-based assays may reach practice as labora...
Small Extracellular Vesicle-Derived Nidogen 1 Promotes HCC Carcinogenesis via Transglutaminase 3-Mediated YAP/TAZ Signalling [0.03%]
小细胞外囊泡衍生的巢蛋白1通过转谷氨酰胺酶3介导的YAP / TAZ信号促进肝癌发生发展
Cherlie Lot Sum Yeung,Le Cui,Jingyi Wang et al.
Cherlie Lot Sum Yeung et al.
Tumour-derived small extracellular vesicles (sEV) are increasingly recognized as key mediators of cancer progression and metastasis by facilitating intercellular communication. In this study, we identify nidogen 1 (NID1), a basement membran...
Stress-Induced Switch in Small Extracellular Vesicle Secretion: From Constitutive 'Torn Bag Mechanism' to Exocytosis [0.03%]
应激诱导的小细胞外囊泡分泌模式转换：从固有“破裂袋机制”到胞吐作用
Dorina Lenzinger,Lilla Lankovics,István Dudás et al.
Dorina Lenzinger et al.
The biogenesis of small extracellular vesicles (sEVs) is only partially understood. Our recent findings provide evidence that a newly described sEV secretion pathway, the amphiectosome release followed by the sEV discharge by the 'torn bag ...
Tumour-Derived Extracellular Vesicles Containing dsRNA Induce Degradation of Ribosomal Protein mRNA in Platelets [0.03%]
肿瘤来源的含dsRNA囊泡诱导血小板中核糖体蛋白mRNA降解
Gaoge Sun,Yuhuan Tao,Zihan Liu et al.
Gaoge Sun et al.
Extracellular vesicles (EVs) mediate intercellular communication within the tumour microenvironment by carrying cargoes from paracrine parent cells. EVs have attracted great research interest for their ability to carry nucleic acids into re...
Lymphatic Drainage of Cerebrospinal Fluid Using Lymph Node Seeker 64Cu-Labeled Gram-Negative Bacterial Extracellular Vesicles With Positron Emission Tomography (PET) [0.03%]
利用正电子发射断层扫描(PET)和64Cu标记的革兰氏阴性细菌细胞外囊泡检测脑脊液淋巴回流路径
Kyuwan Kim,Changjin Lee,Hayoung Shin et al.
Kyuwan Kim et al.
Cerebrospinal fluid (CSF) is drained into the systemic lymphatics via paravertebral lymph nodes. Superficial and deep cervical lymph nodes collect CSF in mice, but the exact and quantified routes are unknown. Recently, we simultaneously vis...
Iron Salts, but Not Iron Oxide Nanoparticles, Drive High-Yield Production of Iron-Engineered Extracellular Vesicles [0.03%]
铁盐而非氧化铁纳米颗粒驱动高产率的铁工程外泌体产生
Elliot Thouvenot,Aurore Van de Walle,Jean-Michel Guigner et al.
Elliot Thouvenot et al.
Efficient production of iron-engineered extracellular vesicles (EVs) is of interest for their use as delivery systems in biotherapy. In this study, we investigated the role of iron in EV biogenesis and evaluated a scalable fluidic strategy ...
Rituximab Binding Endows CD20+ Extracellular Vesicles With NK Cell-Activating Properties in B Cell Lymphoma [0.03%]
利妥昔单抗结合使CD20阳性淋巴瘤细胞的细胞外囊泡获得活化自然杀伤细胞的功能
Adrián V Otero,Paula Soledad Pérez,Belen Gaete-Ramírez et al.
Adrián V Otero et al.
Non-Hodgkin lymphoma (NHL), predominantly B cell lymphomas (B-NHL), is currently treated with chemotherapy combined with rituximab (RTX), an anti-CD20 monoclonal antibody. Despite substantial therapeutic advances, treatment resistance and d...
Rituximab Binding Endows CD20+ Extracellular Vesicles With NK Cell-Activating Properties in B Cell Lymphoma [0.03%]
利妥昔单抗结合赋予CD20⁺细胞外囊泡以激活自然杀伤细胞的特性用于B细胞淋巴瘤治疗的研究
Adrián V Otero,Paula Soledad Pérez,Belen Gaete-Ramírez et al.
Adrián V Otero et al.
Non-Hodgkin lymphoma (NHL), predominantly B cell lymphomas (B-NHL), is currently treated with chemotherapy combined with rituximab (RTX), an anti-CD20 monoclonal antibody. Despite substantial therapeutic advances, treatment resistance and d...
Shear-Activated von Willebrand Factor Captures Extracellular Vesicles to Promote Platelet Activation and Metastasis [0.03%]
剪切力激活的血管性血友病因子通过捕获细胞外囊泡促进血小板活化和转移
Yuanyuan Wang,Xiaobo Liu,Pascal Nakielski et al.
Yuanyuan Wang et al.
Plasma proteins are increasingly recognized as key regulators of extracellular vesicle (EV) behaviour in circulation. However, von Willebrand factor (vWF)-the largest multimeric glycoprotein in blood and the only blood protein activated by ...