Identification and characterization of anti-chikungunya virus compounds using a biosafe toolkit [0.03%]
利用生物安全工具包鉴定和表征抗奇克унья病毒化合物
Yang Gao,Guojie Wang,Hanhua Zhang et al.
Yang Gao et al.
Chikungunya virus (CHIKV) is a re-emerging mosquito-borne alphavirus for which no specific antiviral therapy is currently available. During the large outbreak in Foshan, Guangdong Province, China, in July 2025, CHIKV rapidly spread to neigh...
Pre-existing hemagglutinin-specific antibody levels are associated with B-cell repertoire maturation and antibody breadth after influenza vaccination [0.03%]
血凝素特异性抗体水平与流感疫苗接种后的B细胞成熟及广度的相关性研究
Wei Wang,Yan Sun,Qing Liu et al.
Wei Wang et al.
Repeated influenza exposures generate complex antibody landscapes, yet how pre-existing antibodies are associated with subsequent vaccine responses remains unclear. We longitudinally tracked 21 adults stratified by pre-vaccination neutraliz...
Ferritin nanoparticle-based vaccine enhances mucosal immunity by promoting antigen uptake and activation of alveolar macrophages [0.03%]
基于铁蛋白纳米颗粒的疫苗通过促进抗原摄取和气道巨噬细胞活化增强黏膜免疫响应
Xiantao Zhang,Yingtong Lin,Jie Liu et al.
Xiantao Zhang et al.
SARS-CoV-2 3CLpro inhibits the replication of influenza viruses through the cleavage of NP and PA [0.03%]
SARS-CoV-2 3CLpro通过切割NP和PA抑制流感病毒复制
Liubing Du,Xiaoyu Cai,Ziliang Peng et al.
Liubing Du et al.
The co-circulation of multiple viruses can lead to distinct pathological outcomes, yet how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection influences other viral infections remains poorly understood, despite its docum...
Stabilization of prefusion hMPV F improves manufacturability and protective immunity across hMPV lineages [0.03%]
稳定化的hMPV融合前F蛋白免疫原改善了不同遗传谱系人偏肺病毒（hMPV）的保护性免疫并提高其可制造性
Changbin Qu,Jingjing Zou,Dongyu Niu et al.
Changbin Qu et al.
Human metapneumovirus (hMPV) is a major cause of pediatric acute lower respiratory tract infections (ALRTIs), yet vaccine development has been hindered by the intrinsic metastability of the prefusion F glycoprotein (pre-F). Here, we used a ...
A Modular APEX Biosensor Enables Sensitive and Visualized Monitoring of Viral Protease Activity [0.03%]
模块化APEX生物传感器能够敏感且直观地监测病毒蛋白酶活性
Biao Li,Bao Dong,Yuehong Chen et al.
Biao Li et al.
Viral proteases are key targets for the development of broad-spectrum antiviral drugs development. However, screening platform capable of accurately assessing inhibitor activity within physiologically relevant cellular environments remain u...
Genetic heterogeneity and pathogenic potential of historical Crimean-Congo hemorrhagic fever virus isolates in China [0.03%]
中国历史上的克里米亚-刚果出血热病毒分离株的遗传异质性和致病潜力
Abulimiti Moming,Yuan Bai,Qiong Zhu et al.
Abulimiti Moming et al.
The Crimean-Congo hemorrhagic fever virus (CCHFV) poses a significant public health threat. In China, CCHFV has been circulating for decades, yet the genomic diversity and pathogenic potential of the circulating strains remain poorly charac...
A replication-defective tick-borne encephalitis virus generated by NS1 trans-complementation confers robust protective efficacy [0.03%]
通过NS1跨互补作用产生的复制缺陷型蜱传脑炎病毒具有很好的保护效果
Ji Zhang,Qiu-Yan Zhang,Zhe-Rui Zhang et al.
Ji Zhang et al.
Tick-borne encephalitis virus (TBEV) poses a severe threat to public health, causing neurological disorders with high morbidity and mortality in endemic regions. Therefore, developing safe and effective strategies for TBEV vaccines has long...
Jie Zou,Yuxin Lin,Chunyan Wu et al.
Jie Zou et al.
Mammalian embryonic stem cells (ESCs), despite lacking functional interferon (IFN) signaling, are remarkably resistant to viral infection. However, the mechanistic basis of their antiviral defenses remains incompletely characterized. In thi...
Host OTUB2 and viral plpro stabilize NSP8 to promote SARS-CoV-2 replication [0.03%]
宿主OTUB2和病毒PLPRO通过稳定NSP8促进SARS-CoV-2复制
Wenying Gao,Hongfei Wang,Jingguo Xin et al.
Wenying Gao et al.
The ubiquitin-proteasome system (UPS) plays a central role in antiviral defense but is also frequently hijacked by viruses to facilitate their replication. Here, we demonstrate that the host deubiquitinase OTUB2 stabilizes the viral replica...