Stabilization of prefusion hMPV F improves manufacturability and protective immunity across hMPV lineages
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Human metapneumovirus (hMPV) is a major cause of pediatric acute lower respiratory tract infections (ALRTIs), yet vaccine development has been hindered by the intrinsic metastability of the prefusion F glycoprotein (pre-F). Here, we used a structure-based desi... ...
