Genetic heterogeneity and pathogenic potential of historical Crimean-Congo hemorrhagic fever virus isolates in China [0.03%]
中国历史上的克里米亚-刚果出血热病毒分离株的遗传异质性和致病潜力
Abulimiti Moming,Yuan Bai,Qiong Zhu et al.
Abulimiti Moming et al.
The Crimean-Congo hemorrhagic fever virus (CCHFV) poses a significant public health threat. In China, CCHFV has been circulating for decades, yet the genomic diversity and pathogenic potential of the circulating strains remain poorly charac...
A replication-defective tick-borne encephalitis virus generated by NS1 trans-complementation confers robust protective efficacy [0.03%]
通过NS1跨互补作用产生的复制缺陷型蜱传脑炎病毒具有很好的保护效果
Ji Zhang,Qiu-Yan Zhang,Zhe-Rui Zhang et al.
Ji Zhang et al.
Tick-borne encephalitis virus (TBEV) poses a severe threat to public health, causing neurological disorders with high morbidity and mortality in endemic regions. Therefore, developing safe and effective strategies for TBEV vaccines has long...
Jie Zou,Yuxin Lin,Chunyan Wu et al.
Jie Zou et al.
Mammalian embryonic stem cells (ESCs), despite lacking functional interferon (IFN) signaling, are remarkably resistant to viral infection. However, the mechanistic basis of their antiviral defenses remains incompletely characterized. In thi...
Host OTUB2 and viral plpro stabilize NSP8 to promote SARS-CoV-2 replication [0.03%]
宿主OTUB2和病毒PLPRO通过稳定NSP8促进SARS-CoV-2复制
Wenying Gao,Hongfei Wang,Jingguo Xin et al.
Wenying Gao et al.
The ubiquitin-proteasome system (UPS) plays a central role in antiviral defense but is also frequently hijacked by viruses to facilitate their replication. Here, we demonstrate that the host deubiquitinase OTUB2 stabilizes the viral replica...
MMF inhibits poxvirus infection by disrupting IMPDH2 interaction with USP5 and inducing its Rod-and-Ring assemblies [0.03%]
MMF通过干扰IMPDH2与USP5的相互作用并促使其Rod-and-Ring聚合体的形成来抑制痘病毒入侵
Qian Sun,Kesen Liu,Wandi Cao et al.
Qian Sun et al.
Monkeypox virus (MPXV), a pathogenic orthopoxvirus, has caused major outbreaks and emerged as a global public health threat. Although antivirals approved for smallpox are used therapeutically against monkeypox, their clinical utility is lim...
ZNF598 enhances FAT10-mediated non-covalent stabilization of Tat to promote HIV-1 transcription and replication [0.03%]
锌指抗病毒蛋白ZNF598通过增强FAT10介导的Tat非共价稳定促进HIV-1转录和复制
Hongyun Shi,Panpan Quan,Chaohui Tang et al.
Hongyun Shi et al.
Human immunodeficiency virus type 1 (HIV-1) Tat is essential for efficient viral transcription and replication, and its stability is tightly controlled by host factors. In our previous study, we showed that ZNF598 stabilizes Tat and promote...
Pygenic Acid A, a Small-Molecule PD-1/SHP-2 Inhibitor, Enhances Efficacy of Therapeutic Melanoma Vaccines and Prophylactic Influenza Vaccines [0.03%]
一种小分子PD-1/SHP-2抑制剂吡咯替尼A能够增强治疗性黑色素瘤疫苗和预防性流感疫苗的功效
Yan Yan,Yitong Li,Wenyi Mei et al.
Yan Yan et al.
Overcoming immunosuppressive tumor microenvironments remains a critical challenge in advanced vaccine development. Here, we evaluated Pygenic acid A (PA), an intracellular small-molecule inhibitor targeting the PD-1/SHP-2 axis, as a novel v...
Lin Xu,Edward C Holmes,Weifeng Shi
Lin Xu
Whole-genome evolutionary dynamics of human parainfluenza virus type 3 in Shanghai, China, 2016-2024 [0.03%]
2016-2024年中国上海市人副流感病毒3型全基因组进化动态
Yuqing Zhou,Xiao Wang,Lu Zhang et al.
Yuqing Zhou et al.
Effectiveness of lignans against severe fever with thrombocytopenia syndrome virus infection [0.03%]
木脂素对严重发热伴血小板减少综合征病毒感染的有效性研究
Jun Huang,Jinpeng Lv,Xiaojie Zheng et al.
Jun Huang et al.
Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne bunyavirus that causes a life-threatening infectious disease with high mortality. Currently, there are no approved vaccines or specific therapeutic drugs fo...