Phylogenomics and structural modelling feature accelerated evolution of Oropouche virus: 1955 to 2024 [0.03%]
1955年至2024年.Oropuche病毒的系统基因组学和结构建模特征显示其加速进化
Yibo Ding,Jiajing Li,Xin Wang et al.
Yibo Ding et al.
A large multi-country outbreak of Oropouche virus (OROV), a segmented negative-sense RNA virus, is emerging in Latin America. By analyzing publicly available whole-genome sequences spanning 1955 to 2024, this study reveals accelerated spati...
Synthetic genomics-based generation of the tick-borne encephalitis virus Siberian subtype prototype strain and E51K-attenuated variant for vaccine development and antiviral screening [0.03%]
基于合成基因组学的春黄病毒西伯利亚亚型原型株及其E51K弱毒疫苗候选株的构建与分析
Tolganay Kulatay,Elena Sedova,Alexander Shevtsov et al.
Tolganay Kulatay et al.
Tick-borne encephalitis virus (TBEV) is a re-emerging pathogen in Kazakhstan, where the increasing risk of its spread underscores the need for improved healthcare preparedness, including the development of local vaccines. However, the absen...
HBV and host metabolic crosstalk: reprogramming pathways for viral replication and pathogenesis [0.03%]
乙型肝炎病毒与宿主代谢相互作用：重编病毒复制和发病机制的途径
YanYing Yan,Zhiqiang Wei,Min Zheng et al.
YanYing Yan et al.
Hepatitis B virus (HBV) establishes chronic infection through strategic manipulation of host metabolic networks, driving a spectrum of hepatic pathologies ranging from hepatitis to cirrhosis and hepatocellular carcinoma. Mechanistically, HB...
The pathogenic role and genomic characteristics of Epstein-Barr virus in Vitreoretinal Lymphoma [0.03%]
Epstein-Barr病毒在玻璃体视网膜淋巴瘤中的致病作用及其基因组特征
Xiaoqing Liu,Guangjie Jiang,Chianru Tan et al.
Xiaoqing Liu et al.
Epstein-Barr virus (EBV) infection is a well-known for its association with lymphoproliferative disorders and various lymphomas, causing significant global morbidity and mortality. EBV-positive vitreoretinal lymphoma (VRL) is exceedingly ra...
First identification of Tusavirus in calf intestinal tissue suggests interspecies transmission and genomic variation [0.03%]
牛肠组织中Tusavirus的首次鉴定表明了跨物种传播和基因组变异
Yang Song,Weiwei Gai,Jiaxin Sun et al.
Yang Song et al.
Epidemiological, Phylogenetic, and Pathogenicity Analysis of H4 Subtype Avian Influenza Viruses in China, 2011-2022 [0.03%]
中国H4亚型禽流感病毒的流行病学、谱系和致病性分析（2011-2022年）
Qiuyan Mao,Junfeng Zhu,Shuo Liu et al.
Qiuyan Mao et al.
The H4 subtype of avian influenza virus (AIV) is prevalent worldwide, but often receives little attention due to its low pathogenicity in poultry. Consequently, it remains largely unclear whether H4 AIVs pose a potential threat to the poult...
Long-term surveillance of avian avulavirus in wild birds in China from 2003-2020 [0.03%]
中国2003-2020年野鸟中低致病性禽流感病毒的长期监测
Qing An,Yi Li,Xinru Lv et al.
Qing An et al.
Avian avulavirus (AAVV) is a significant pathogen affecting avian species, but research on its prevalence in wild birds in China has been relatively limited. In this study, active surveillance for AAVV was conducted in wild birds in China f...
Genetic analysis of human adenovirus type 108 circulating in China during 2014-2024 [0.03%]
2014-2024年在中国流行的腺病毒108型的基因分析
Jinjin Wang,Ling Jing,Yali Duan et al.
Jinjin Wang et al.
Human adenovirus type 108 (HAdV-108) has been detected in multiple countries, including China, and is associated with severe acute respiratory infection (ARI) in children, with reported fatalities. However, studies on HAdV-108 remain limite...
Antisera and antivirals targeting the conserved domains in SARS-CoV-2 S2 subunit are effective against ACE2-using MERSr-CoVs with spillover potential [0.03%]
靶向SARS-CoV-2 S2亚基保守结构域的抗血清和抗病毒药物可有效应对具有溢出风险的使用ACE2受体的MERSr-CoV毒株
Lujia Sun,Bianying Feng,Zezhong Liu et al.
Lujia Sun et al.
A Safe and Broad-spectrum SARS-CoV-2 mRNA Vaccine with a New Delivery System for In-situ Expression [0.03%]
一种新型递送系统的广谱安全的SARS-CoV-2 mRNA疫苗用于原位表达
Weiyi Yu,Xianying Chen,Qiubing Chen et al.
Weiyi Yu et al.
Since the outbreak of SARS-CoV-2 in late 2019, the cumulative number of confirmed cases worldwide has surpassed 778 million, and the number of deaths has exceeded 7 million, posing a significant threat to human life and health while inflict...