Sedative-Hypnotic and Receptor Binding Studies of Fermented Marine Organisms [0.03%]
海洋发酵产物的镇静及受体作用研究
Hye-Young Joung,Young Mi Kang,Bae-Jin Lee et al.
Hye-Young Joung et al.
This study was performed to investigate the sedative-hypnotic activity of γ-aminobutyric acid (GABA)-enriched fermented marine organisms (FMO), including sea tangle (FST) and oyster (FO) by Lactobacillus brevis BJ20 (L. brevis BJ20). FST a...
Anti-Oxidative Effect of Myrtenal in Prevention and Treatment of Colon Cancer Induced by 1, 2-Dimethyl Hydrazine (DMH) in Experimental Animals [0.03%]
单茋类化合物抗肿瘤活性研究及其作用机制探讨
Booupathy Lokeshkumar,Venkatachalam Sathishkumar,Natarajan Nandakumar et al.
Booupathy Lokeshkumar et al.
Colon cancer is considered as the precarious forms of cancer in many developed countries, with few to no symptoms; the tumor is often diagnosed in the later stages of cancer. Monoterpenes are a major part of plant essential oils found large...
Antiviral Activity of Chrysin Derivatives against Coxsackievirus B3 in vitro and in vivo [0.03%]
chrysin衍生物体内外抗柯萨奇病毒B3活性研究
Jae-Hyoung Song,Bo-Eun Kwon,Hongjun Jang et al.
Jae-Hyoung Song et al.
Chrysin is a 5,7-dihydroxyflavone and was recently shown to potently inhibit enterovirus 71 (EV71) by suppressing viral 3C protease (3C(pro)) activity. In the current study, we investigated whether chrysin also shows antiviral activity agai...
Gastroprotective Activities of Sennoside A and Sennoside B via the Up-Regulation of Prostaglandin E2 and the Inhibition of H(+)/K(+)-ATPase [0.03%]
大黄酚A和B通过促进前列腺素E2的合成和抑制H(+)/K(+)-ATP酶发挥胃保护作用
In Young Hwang,Choon Sik Jeong
In Young Hwang
Sennoside A (erythro) and sennoside B (threo) are dianthrone glycosides and diastereomers. We investigated their abilities to prevent the gastric lesions associated with diseases, such as, gastritis and gastric ulcer. To elucidate their gas...
A Dunnione Compound MB12662 Improves Cisplatin-Induced Tissue Injury and Emesis [0.03%]
杜宁烷类化合物MB12662改善顺铂所致组织损伤和呕吐反应
Dongsun Park,In Geun Jo,Ja Young Jang et al.
Dongsun Park et al.
The present study was aimed to investigate the effects of MB12662, a synthetic dunnione compound, on cisplatin-induced vomiting reflexes and intestinal, renal, immune system, and hematopoietic toxicities in ferrets and mice, respectively. M...
Chondroprotective Effects of Wogonin in Experimental Models of Osteoarthritis in vitro and in vivo [0.03%]
一种黄酮类化合物姜黄素对软骨保护作用及机制研究
Jin Sung Park,Hyun Jae Lee,Dong Yeong Lee et al.
Jin Sung Park et al.
We evaluated the chondroprotective effects of wogonin by investigating its effects on the gene expression and production of matrix metalloproteinase-3 (MMP-3) in primary cultured rabbit articular chondrocytes, as well as on production of MM...
A New Histone Deacetylase Inhibitor, MHY219, Inhibits the Migration of Human Prostate Cancer Cells via HDAC1 [0.03%]
新型组蛋白去乙酰化酶抑制剂MHY219通过HDAC1抑制人前列腺癌细胞迁移
Umasankar De,Soma Kundu,Nabanita Patra et al.
Umasankar De et al.
Histone deacetylase (HDAC) inhibitors are considered novel agents for cancer chemotherapy. We previously investigated MHY219, a new HDAC inhibitor, and its potent anticancer activity in human prostate cancer cells. In the present study, we ...
Acetylshikonin Inhibits Human Pancreatic PANC-1 Cancer Cell Proliferation by Suppressing the NF-κB Activity [0.03%]
阿魏酸抑制人胰腺PANC-1癌细胞增殖通过抑制NF-κB活性
Seok-Cheol Cho,Bu Young Choi
Seok-Cheol Cho
Acetylshikonin, a natural naphthoquinone derivative compound, has been used for treatment of inflammation and cancer. In the present study, we have investigated whether acetylshikonin could regulate the NF-κB signaling pathway, thereby lea...
Imperatorin Suppresses Degranulation and Eicosanoid Generation in Activated Bone Marrow-Derived Mast Cells [0.03%]
帝后草提取物通过抑制小鼠骨髓源性肥大细胞去颗粒化和白三烯生成发挥抗哮喘作用
Kyu-Tae Jeong,Eujin Lee,Na-Young Park et al.
Kyu-Tae Jeong et al.
Imperatorin has been known to exert many biological functions including anti-inflammatory activity. In this study, we investigated the inhibitory effects of imperatorin on the production of inflammatory mediators in mouse bone marrow-derive...
Fisetin Suppresses Macrophage-Mediated Inflammatory Responses by Blockade of Src and Syk [0.03%]
山奈酚通过阻断Src和Syk抑制巨噬细胞介导的炎症反应
Jun Ho Kim,Mi-Yeon Kim,Jong-Hoon Kim et al.
Jun Ho Kim et al.
Flavonoids, such as fisetin (3,7,3',4'-tetrahydroxyflavone), are plant secondary metabolites. It has been reported that fisetin is able to perform numerous pharmacological roles including anti-inflammatory, anti-microbial, and anti-cancer a...