Mechanistic Insights into Nrf2 Activation and Oxidative Stress Responses of Per- and Polyfluoroalkyl Substances (PFAS) in Human Keratinocytes [0.03%]
人表皮细胞中 PFAS 激活 Nrf2 和氧化应激的机制研究
Samantha Serafin Sevilleno,Hye Jin Park,Min Sik Choi
Samantha Serafin Sevilleno
Per- and polyfluoroalkyl substances (PFAS) are widely used in consumer products for their hydrophobic and chemical stability, yet their dermatotoxicological effects remain underexplored. This study investigated the ability of representative...
TRPV4 Activation Promotes Hair Growth via TSLP Signaling in the Skin [0.03%]
通过皮肤中的TSLP信号促进毛发生长的TRPV4激活作用
Wook-Joo Lee,Won-Sik Shim
Wook-Joo Lee
Hair follicle cycling is regulated by complex signaling networks that coordinate stem cell activation and quiescence. Although transient receptor potential vanilloid 4 (TRPV4) is expressed in the skin and implicated in cutaneous physiology,...
Isoschaftoside Inhibits Osteoclastogenesis by Suppressing the NF-κB and MAPK Pathways [0.03%]
异株金莲花黄酮通过抑制NF-κB和MAPK途径来抑制破骨细胞的生成
Jangmi Yun,Ki Yong Lee,Byoungduck Park
Jangmi Yun
Bone remodeling is regulated by the equilibrium between bone formation and resorption. However, excessive bone resorption by osteoclasts disrupts bone homeostasis and contributes to several bone-related disorders. Hematopoietic lineage cell...
NMR-Based Metabolic Profiling of Biobank Derived Blood Samples for the Identification of Liver Disease Biomarkers [0.03%]
基于生物样本库血液样品的核磁共振代谢轮廓分析在肝病生物标志物鉴定中的应用研究
Munki Choo,Chaeyoung Lee,Sunghyouk Park et al.
Munki Choo et al.
Liver disease remains a leading cause of global cancer mortality and predominantly originates from chronic liver cirrhosis. Current surveillance strategies often suffer from suboptimal sensitivity which necessitates the discovery of robust ...
A Novel DRD2 Antagonist, SD2-2305, Exerts Anticancer Effects in Colorectal Cancer Cells through G1 Arrest and Caspase-Dependent Apoptosis [0.03%]
新型多巴胺受体DA D2拮抗剂SD2-2305通过G1期阻滞和Caspase依赖性凋亡对结直肠癌细胞发挥抗癌作用
Na Hyun Kim,Geun Young Cho,In-Tae Kim et al.
Na Hyun Kim et al.
Colorectal cancer (CRC) remains difficult to treat due to challenges in early detection and the development of therapeutic resistance. Dopamine receptor D2 (DRD2) plays a critical role in regulating cell proliferation and apoptosis in vario...
Erastin-Induced Ferroptosis Overcomes Oxaliplatin Resistance in Colorectal Cancer Cells [0.03%]
二氯苯醌诱导的铁死亡可克服奥沙利铂耐药性
Na Yeong Lee,Sang Hoon Joo,Si Yeong Seo et al.
Na Yeong Lee et al.
Chemotherapy resistance remains a significant obstacle in the treatment of colorectal cancer (CRC) patients. Here, we examined the ferroptosis susceptibility of the chemotherapy-resistant CRC cell line HCT116-OxR relative to its parental co...
Bioprocess Development of a Human Monoclonal Antibody against MERS-CoV: Analytical and Preclinical Studies [0.03%]
人单克隆抗体MCA13针对中东呼吸综合征冠状病毒的生物工艺开发：分析和临床前研究
Jongsun Lim,Hansaem Lee,Joo-Yeon Lee et al.
Jongsun Lim et al.
Middle East Respiratory Syndrome coronavirus (MERS-CoV) is a zoonotic virus first identified in 2012, responsible for severe respiratory illness and a high case fatality rate of approximately 35%. MERS-CoV is primarily transmitted from drom...
Behavioral and Biochemical Evaluation of a Curcumin-Loaded Nano-Liposomal Formulation in a Scopolamine-Induced Mouse Model of Cognitive Impairment [0.03%]
行为和生化评价：姜黄素载药脂质纳米制剂用于阿托品诱导的小鼠认知障碍模型
Hwa-Young Lee,Muhammad Kamal Hossain,Gi-Hyun Jang et al.
Hwa-Young Lee et al.
Scopolamine-induced cognitive impairment in mice models acute cholinergic dysfunction associated with early functional features of Alzheimer's disease (AD). This study evaluated the neuroprotective potential of curcumin-loaded nanoliposomes...
6-Shogaol Complements Levodopa Therapy by Modulating Brain-Gut Metabolomes in a Parkinson's Disease Model [0.03%]
姜酚通过调节帕金森病模型中的脑-肠代谢物互补左旋多巴治疗作用
Jin Hee Kim,Seungmin Lee,Yujin Choi et al.
Jin Hee Kim et al.
Levodopa remains the primary therapy for Parkinson's disease (PD); however, its benefits are largely confined to motor symptom relief, without altering disease progression. Growing evidence implicates the gut-brain axis in PD, linking gastr...
Simvastatin Protects the Dopaminergic Neurons from MPTP-Mediated Injury by Inducing BDNF via PPARα Activation [0.03%]
PPARα活化诱导BDNF产生介导辛伐他汀对MPTP致多巴胺能神经元损伤的保护作用
Ganesh Bohara,Nikesh Rimal,Shristi Khanal et al.
Ganesh Bohara et al.
Parkinson's disease (PD) is a neurodegenerative disease characterized by preferential loss of the dopaminergic neurons in the nigrostriatal pathway. The specific molecular mechanisms for the neuronal loss remain unclear, and no cure current...