Exploring LEPR-Linked Metabolic Diversity through Gut Microbiome-Metabolome Network Analysis in Non-Obese Adults [0.03%]
通过肠道微生物组-代谢组网络分析在非肥胖成年人群中探索LEPR相关的代谢多样性
Kyeong-Seog Kim,Joo-Youn Cho,Ye Chan Park et al.
Kyeong-Seog Kim et al.
Genetic variation in the leptin receptor (LEPR) gene has been implicated in metabolic regulation, while the gut microbiome and circulating metabolites are increasingly recognized as mediators of host metabolic phenotype. However, the system...
Celafolin A-1 Ameliorates Subretinal Fibrosis via Inhibition of Crystallin Alpha B in a Laser-Induced Choroidal Neovascularization Mouse Model [0.03%]
塞来福林A-1通过抑制激光诱导的脉络膜新生血管小鼠模型中的αB晶体蛋白改善视网膜下纤维化
Eunhye Yu,Sun Mi Gu,Haechan Kim et al.
Eunhye Yu et al.
Age-related macular degeneration (AMD) is a leading cause of blindness in people over 65 years old. Anti-vascular endothelial growth factor (VEGF) therapy is the first-line treatment for neovascular AMD (nAMD); however, fibrosis remains an ...
Crebanine Protects HUVECs from LPS-Induced Inflammation and Oxidative Stress by Suppressing NF-κB Pathway [0.03%]
克雷班宁通过抑制NF-κB途径保护内皮细胞免受脂多糖诱导的炎症和氧化应激损伤
Hao Chen,Liyuan Luo,Yunzhu Guo et al.
Hao Chen et al.
Endothelial dysfunction induced by inflammation and oxidative stress represents a critical pathological mechanism in cardiovascular and cerebrovascular diseases, including sepsis and atherosclerosis. Although crebanine has been reported to ...
Pluviatolide Attenuates Type I Hypersensitivity through Regulation of Mast Cell Activation [0.03%]
雨曲素通过调节肥大细胞活化抑制I型超敏反应
Seon Young Kim,Jeong Won Park,Juhyun Shin et al.
Seon Young Kim et al.
This study examined the inhibitory effects of pluviatolide, a lignan derived from Podophyllum hexandrum, on mast cell activation and IgE-mediated type I hypersensitivity, focusing on FcεRI-dependent and calcium-mediated pathways. Using bon...
γ-Oryzanol Ameliorates Endothelial Replicative Senescence via Downregulation of SGLT2 Expression to Attenuate NADPH-Driven Oxidative Stress [0.03%]
γ-稻谷醇通过下调SGLT2表达来缓解内皮细胞复制性衰老以减轻NADPH驱动的氧化应激
Saugat Shiwakoti,Kushal Sharma,Dal-Seong Gong et al.
Saugat Shiwakoti et al.
Replicative senescence in endothelial cells is characterized by an irreversible cell cycle arrest and impaired endothelial function, contributing to vascular aging and cardiovascular disease. Natural compounds are being actively studied for...
Exploratory Proteomic Profiling Reveals Potential Mediators of 5-FU Response under p53 Deficiency in Colon Cancer Cells [0.03%]
探索性蛋白质组学分析发现结肠癌细胞中p53缺陷状态下5-氟尿嘧啶响应的潜在介导因素
Seonyong Lee,Jiwon Lee,Ga Seul Lee et al.
Seonyong Lee et al.
Mutations in p53 have been implicated in poor prognosis and reduced sensitivity to 5-fluorouracil (5-FU) treatment in colon cancer. While p53-dependent mechanisms have been widely studies, less is known about how p53 deficiency reshapes cel...
Bioinformatic Analysis to Identify Biomarker Candidates of Complex Karyotype Soft Tissue Sarcomas with CDK4-Amplification [0.03%]
生物信息分析鉴定复杂染色体变异型CDK4扩增型软组织肉瘤生物标志物候选分子
Eun-Young Lee,Hyun Sang Cho,June Hyuk Kim et al.
Eun-Young Lee et al.
Soft tissue sarcomas (STSs), a diverse group of mesenchymal malignancies, are characterized primarily by copy-number alterations rather than a high tumor mutation burden. In this study, we sought to identify expression-based biomarkers in c...
Aβ₁₋₄₀ Enhances Platelet Sensitivity to Thrombin via NADPH Oxidase-ROS Signaling and Integrin αIIbβ₃ Engagement [0.03%]
AB₁₋₄₀通过NADPH氧化酶-ROS信号和整合素αIIbβ₃参与增强血小板对凝血酶的敏感性
Been Kim,Bo Kyung Lee,Jung-Ae Kim et al.
Been Kim et al.
Alzheimer's disease (AD) is increasingly recognized as a disorder with significant vascular involvement, with microvascular damage and thromboinflammation often preceding classical amyloid pathology by several years. Elevated levels of prot...
Role of Adenosine Receptors in Sleep Deprivation-Induced Depression-Like Behaviors [0.03%]
腺苷受体在睡眠剥夺诱导的类似抑郁行为中的作用
Nan Ju Lee,Yi-Sook Jung
Nan Ju Lee
Sleep deprivation (SD) disrupts homeostatic regulation and increases vulnerability to stress and mood disorders. This study investigated the duration-dependent effects of SD and elucidated the distinct roles of adenosine A1 receptors (A1R) ...
Clemastine Restores Myelination Protein Expression in S16 Schwann Cells by Enhancing AMPK Activation and Reducing H2O2-Induced Oxidative Stress [0.03%]
氯马斯汀通过增强AMPK活化和减少H2O2诱导的氧化应激恢复S16雪旺细胞髓鞘蛋白质表达
Chawon Yun,So Young Lee,Jun Hong Won et al.
Chawon Yun et al.
Peripheral nerve injury and oxidative stress can severely impair Schwann cell function by disrupting the expression of key myelin proteins, promoting intracellular lipid accumulation, and damaging mitochondrial integrity. These pathological...