Hye-Kyung Choi,Eun-Kyung Won,Se-Young Choung
Hye-Kyung Choi
Statins, HMG-CoA reductase inhibitors, are known to cause serious muscle injuries (e.g. myopathy, myositis and rhabdomyolysis), and these adverse effects can be rescued by co-administration of coenzyme Q10 (CoQ10) with statins. The goal of ...
Blockade of P-Glycoprotein Decreased the Disposition of Phenformin and Increased Plasma Lactate Level [0.03%]
P-糖蛋白抑制减弱苯甲福明的药代动力学并增加血浆乳酸水平
Min-Koo Choi,Im-Sook Song
Min-Koo Choi
This study aimed to investigate the in vivo relevance of P-glycoprotein (P-gp) in the pharmacokinetics and adverse effect of phenformin. To investigate the involvement of P-gp in the transport of phenformin, a bi-directional transport of ph...
Bo Kyung Park,Edson Luck T Gonzales,Sung Min Yang et al.
Bo Kyung Park et al.
Triclosan is an antimicrobial or sanitizing agent used in personal care and household products such as toothpaste, soaps, mouthwashes and kitchen utensils. There are increasing evidence of the potentially harmful effects of triclosan in man...
Effects of Bisphosphonates on Glucose Transport in a Conditionally Immortalized Rat Retinal Capillary Endothelial Cell Line (TR-iBRB Cells) [0.03%]
双膦酸盐对条件永生化大鼠视网膜内皮细胞葡萄糖转运的影响(TR-iBRB细胞)
Na-Young Lee,Hyun-Joo Park,Young-Sook Kang
Na-Young Lee
The objective of the present study was to elucidate the effect of bisphosphonates, anti-osteoporosis agents, on glucose uptake in retinal capillary endothelial cells under normal and high glucose conditions. The change of glucose uptake by ...
Anti-Melanogenic Potentials of Nanoparticles from Calli of Resveratrol-Enriched Rice against UVB-Induced Hyperpigmentation in Guinea Pig Skin [0.03%]
富白藜芦醇水稻愈伤组织纳米颗粒的抗黑素生成潜力及其对紫外线诱导的皮肤色素沉着作用研究
Taek Hwan Lee,Ji Hee Kang,Jae Ok Seo et al.
Taek Hwan Lee et al.
We already reported that genetically engineered resveratrol-enriched rice (RR) showed to down-regulate skin melanogenesis. To be developed to increase the bioactivity of RR using calli from plants, RR was adopted for mass production using p...
Rosmarinic Acid Attenuates Cell Damage against UVB Radiation-Induced Oxidative Stress via Enhancing Antioxidant Effects in Human HaCaT Cells [0.03%]
岩梗酸通过增强抗氧化作用缓解UVB辐射诱导的人HaCaT细胞氧化应激损伤
Pattage Madushan Dilhara Jayatissa Fernando,Mei Jing Piao,Kyoung Ah Kang et al.
Pattage Madushan Dilhara Jayatissa Fernando et al.
This study was designed to investigate the cytoprotective effect of rosmarinic acid (RA) on ultraviolet B (UVB)-induced oxidative stress in HaCaT keratinocytes. RA exerted a significant cytoprotective effect by scavenging intracellular ROS ...
Inhibition of Lung Inflammation by Acanthopanax divaricatus var. Albeofructus and Its Constituents [0.03%]
Acanthopanax divaricatus var. Albeofructus及其成分抑制肺部炎症作用的研究
Ju Hee Lee,Ya Nan Sun,Young Ho Kim et al.
Ju Hee Lee et al.
In order to find potential therapeutic agents on lung inflammatory conditions, the extracts of Acanthopanax divaricatus var. albeofructus were prepared and its constituents were isolated. They include lignans such as (+)-syringaresinol (1),...
Amygdalin Regulates Apoptosis and Adhesion in Hs578T Triple-Negative Breast Cancer Cells [0.03%]
苦杏仁苷通过调节凋亡和粘附对三阴性乳腺癌细胞系Hs578T的抑制作用
Hye Min Lee,Aree Moon
Hye Min Lee
Amygdalin, D-mandelonitrile-β-D-glucoside-6-β-glucoside, belongs to aromatic cyanogenic glycoside group derived from rosaceous plant seed. Mounting evidence has supported the anti-cancer effects of amygdalin. However, whether amygdalin in...
Endothelium-Independent Effect of Fisetin on the Agonist-Induced Regulation of Vascular Contractility [0.03%]
fisetin对激动剂诱导的血管收缩调节的影响并非由内皮介导
Hyun Dong Je,Uy Dong Sohn,Hyen-Oh La
Hyun Dong Je
Fisetin, a natural flavonoid found in a variety of vegetables and fruits, has been shown to possess many biological functions. The present study was undertaken to investigate the influence of fisetin on vascular smooth muscle contractility ...
Aloe-Emodin Protects RIN-5F (Pancreatic β-cell) Cell from Glucotoxicity via Regulation of Pro-Inflammatory Cytokine and Downregulation of Bax and Caspase 3 [0.03%]
Aloerfin通过调节促炎细胞因子和下调Bax和Caspase 3来保护RIN-5F（胰岛β细胞）免受高糖毒性的影响
Ali A Alshatwi,P Subash-Babu
Ali A Alshatwi
To determine the protective effect of aloe-emodin (AE) from high glucose induced toxicity in RIN-5F (pancreatic β-cell) cell and restoration of its function was analyzed. RIN-5F cells have been cultured in high glucose (25 mM glucose) cond...