Hemostasis-Sparing Antiplatelet Therapy: Current Concepts and Emerging Targets in Arterial Thrombosis [0.03%]
兼顾止血的抗血小板治疗：动脉血栓形成的当前概念和新兴靶点
Ji Won Park,Eun Bee Oh,Tong-Shin Chang
Ji Won Park
Arterial thrombosis remains a leading cause of cardiovascular morbidity and mortality despite widespread use of dual antiplatelet therapy (DAPT) with aspirin and P2Y12 inhibitors. Although these agents reduce ischemic events, their efficacy...
Preclinical Pharmacological and Toxicological Evaluation of SB5794, a Novel Aryl Hydrocarbon Receptor Modulator on the Kynurenine-AhR Axis [0.03%]
新型芳香烃受体调节剂SB5794在犬尿酸-芳香烃受体轴的药理学和毒理学的临床前评估研究
Daewon Cha,Soo-Jung Choi,Hyunwoo Park et al.
Daewon Cha et al.
Conventional aryl hydrocarbon receptor (AhR) antagonists, which play a critical role in modulating tumor immune evasion, have shown limited clinical translation due to poor solubility, restricted systemic exposure, and dose-limiting toxicit...
Adaptive Immunity and Alzheimer's Disease: Dual Roles in Neurodegeneration and Neuroprotection with Therapeutic Implications [0.03%]
适应性免疫与阿尔茨海默病：在神经退行性和神经保护中的双重作用及其治疗意义
You Min Ahn,Min-Kyoo Shin
You Min Ahn
Alzheimer's disease (AD) is a progressive neurodegenerative disorder defined by amyloid-β (Aβ) plaques, tau hyperphosphorylation, and neuroinflammation. Although earlier work emphasized brain-resident glia (microglia and astrocytes), rece...
Recent Advances in Therapeutic Approaches for Knee Osteoarthritis: a Narrative Review [0.03%]
膝关节骨关节炎治疗进展的综述性研究
Md Solayman Hossain,Hyun Jae Lee,Rajib Hossain et al.
Md Solayman Hossain et al.
Knee osteoarthritis (KOA) is a progressive and chronic musculoskeletal condition that continues to be the leading cause of disability worldwide. Conventional treatment approaches for the management of KOA largely focus on symptom alleviatio...
Advancing Cancer Immunotherapy: Chimeric Antigen Receptor (CAR)-T Cell Engineering through Novel Screening Methods [0.03%]
通过新型筛选方法推进癌症免疫治疗：嵌合抗原受体(CAR) T细胞工程技术
Junyoung Ha,Jihye Seong
Junyoung Ha
Cancer immunotherapy represents a paradigm-shifting achievement in oncology. Particularly, chimeric antigen receptor (CAR)-T cell therapy utilizing genetically engineered T cells has produced remarkable clinical responses in hematological m...
Targeting Ferroptosis to Overcome Drug Resistance in Cancer: Molecular Mechanisms and Therapeutic Prospects [0.03%]
靶向铁死亡以克服癌症的药物抵抗：分子机制和治疗前景
Sang Hoon Joo,Yong-Yeon Cho,Jung-Hyun Shim
Sang Hoon Joo
Drug resistance in cancer cells remains a major obstacle limiting the clinical efficacy of current anticancer therapies. The induction of ferroptosis, an iron-dependent, regulated form of cell death, may offer an alternative therapeutic str...
Targeting the Primordial Chaperone to Overcome Acquired Drug Resistance in Cancer: TG2-Mediated Autophagy [0.03%]
靶向初始分子伴侣克服癌症获得性药物耐药性：TG2介导的自噬
Soo-Youl Kim
Soo-Youl Kim
The transglutaminase family is roughly 250 million years old. Horseshoe crabs have been described as a 'living fossil' and have remained virtually unchanged since first appearing around the Triassic period. The horseshoe crab, a living foss...
Navigating the New Therapeutic Landscape: Innovative Strategies for Overcoming Resistance and Degeneration [0.03%]
应对耐药和退变的创新策略——治疗新格局下的思考
Hyun-Jeong Ko,Chang Hoon Lee
Hyun-Jeong Ko
Recent technological advancements and environmental shifts have reshaped the therapeutic landscape of human diseases, driving a transition from merely understanding pathogenesis to developing precise and targeted therapeutic solutions. Whil...
Gene Editing of Pluripotent Stem Cell-Derived Hepatic Cells for Liver Disease Modeling and Therapeutic Development [0.03%]
基因编辑多能干细胞来源的肝细胞用于肝脏疾病建模和治疗开发
Donghyun Lim,Hyung-Ryong Kim
Donghyun Lim
The growing demand for physiologically relevant human liver models has driven significant progress in generating hepatic cells and organoids derived from pluripotent stem cells. These regenerative cell sources serve as powerful platforms fo...
Targeting YAP-TEAD Interaction with Honokiol to Inhibit Melanoma Progression and Metastasis [0.03%]
利用Honokiol靶向YAP-TEAD相互作用抑制黑色素瘤进展和转移
Chaelin Lee,Hien Thi Thu Do,Xiang Fei et al.
Chaelin Lee et al.
The Hippo-YAP/TEAD pathway plays a central role in melanoma progression by regulating tumor cell proliferation, survival, and migration. Using a NanoLuc Binary Technology (NanoBiT) protein-protein interaction assay, we screened honokiol-bas...