FDFT1 Acts as a Negative Regulator of Autophagy by Modulating AMPK-ULK1 Signaling in Hepatocellular Carcinoma Cells [0.03%]
FDFT1通过调节AMPK-ULK1信号在肝癌细胞中作为自噬负调控因子的作用
Thi Ha Nguyen,Yongook Lee,Minh Tuan Nguyen et al.
Thi Ha Nguyen et al.
Autophagy is a conserved catabolic process that degrades proteins and damaged organelles to maintain cellular homeostasis, and its role in cancer depends on stage and context. Farnesyl-diphosphate farnesyltransferase 1 (FDFT1) is an essenti...
RBM15-Mediated m6A Modification Regulates Proliferation and Migration of Pancreatic Cancer Cells via the lncRNA LINC01320/miR-1287-5p/FBXO11 Axis [0.03%]
RBM15介导的m6A修饰通过长非编码RNA LINC01320/miR-1287-5p/FBXO11轴调节胰腺癌细胞增殖和迁移
Xin Deng,Baosheng Wang
Xin Deng
Pancreatic cancer (PC) is life-threatening with unfavorable outcomes. RBM15, an m6A methylation modulator, is a potential biomarker for cancers. This study delved into the mechanism of RBM15-mediated m6A modification in PC. RBM15, LINC01320...
Zoledronic Acid Inhibits the Growth of ER-Positive Breast Cancer Cells by Inducing Ferroptosis [0.03%]
唑来膦酸通过诱导铁死亡抑制ER阳性乳腺癌细胞的生长
Shaofei Yuan,Dejin Shi,Yiyin Xu et al.
Shaofei Yuan et al.
Zoledronic acid (ZA), a nitrogen-containing bisphosphonate with established clinical utility in osteoporosis management, exhibits emerging antitumor potential in estrogen receptor-positive breast cancer. However, the molecular mechanisms un...
Pseudoephedrine Improves Chronic Obstructive Pulmonary Disease by Regulating Airway Senescence and Mitochondrial Function through PI3K/AKT/mTOR Axis [0.03%]
伪麻黄碱通过PI3K/AKT/mTOR轴调节气道衰老和线粒体功能改善慢性阻塞性肺疾病
Lijuan Wu,Fenqiao Chen,He Zhang et al.
Lijuan Wu et al.
Ephedra can improve chronic obstructive pulmonary disease (COPD). Pseudoephedrine (PSE) is a main active ingredients of ephedra. It has anti-inflammatory pharmacological properties. Its effect on COPD and its possible mechanism have not bee...
Proarrhythmic Risk Assessment of Sildenafil under High-Dose Misuse Conditions Using the Comprehensive In Vitro Proarrhythmia Assay (CiPA) [0.03%]
CIpa框架中全面评估西地那非在大剂量误用情况下引起心律失常的风险
Hanbi Kim,Tae Woong Na,Inkyo Jung et al.
Hanbi Kim et al.
The comprehensive in vitro proarrhythmia assay (CiPA) initiative, led by the U.S. Food and Drug Administration (FDA), provides a framework for predicting drug-induced arrhythmia risk. To support domestic CiPA implementation, we evaluated th...
The RIPK3 Inhibitor GSK872 Attenuates Inflammation and Necroptosis via Modulation of the JNK Signaling Pathway in LPS-Stimulated Microglia [0.03%]
GSK872通过调节LPS刺激的小胶质细胞中JNK信号通路来抑制RIPK3并减弱炎症和坏死性凋亡
Jin-Sun Park,Do-Yeon Kim,Seong-Eun Kim et al.
Jin-Sun Park et al.
Microglia are the resident immune cells of the brain; they respond rapidly to inflammatory stimuli and contribute to the progression of neurodegenerative diseases. Receptor-interacting protein kinase 3 (RIPK3) is known to mediate pro-inflam...
Structure-Activity Relationships and Ligand-Dependent Arrestin Bias in μ-Opioid Receptor-Mediated ERK Activation [0.03%]
μ-阿片受体介导的ERK激活作用机制及其配体依赖性偏向性研究
Lei Huang,Mengling Wang,Dooti Kundu et al.
Lei Huang et al.
This study elucidated the structure-activity relationships (SAR) of three distinct opioid ligand series at the µ-opioid receptor (µ-OR) and investigated the ligand-dependent role of arrestin in downstream signaling. Radioligand binding as...
Stress Accelerates Depressive-Like Behaviors through Increase of Notch2 Expression in N141I Mutation Presenilin-2 Transgenic Mice [0.03%]
应激通过增加N141I突变型早老素-2转基因小鼠Notch2表达促进抑郁样行为发生
Seung Sik Yoo,Sun Mi Gu,Kyung Tak Nam et al.
Seung Sik Yoo et al.
Alzheimer's disease (AD) is characterized by progressive cognitive deterioration and significant depression. However, the mechanisms linking depression to AD pathology remain unclear. Here, we investigated whether Notch2 signaling mediates ...
Phytotherapeutic Potential of Medicinal Plants for Atopic Dermatitis: Centella asiatica, Clinacanthus nutans, Senna alata, and Coccinia grandis [0.03%]
治疗特应性皮炎的药用植物的药用潜力：积雪草、Clinacanthus营养、Senna alata和Coccinia大果子宝藤
Thitiluck Swangsri,Naowarat Saralamba
Thitiluck Swangsri
Atopic dermatitis (AD) is a chronic inflammatory skin disorder with significant global health implications, particularly in low-resource settings. In many Asian countries, traditional herbal medicine remains an integral part of healthcare a...
Current and Emerging Therapies Targeting the IL-23/IL-17 Axis in Psoriasis [0.03%]
针对银屑病中白细胞介素23和白细胞介素17轴的当前及新兴疗法
Sang-Jun Han,Go-Yeon Jung,Gyeong-Cheon Lee et al.
Sang-Jun Han et al.
Over the past two decades, experimental and clinical evidence has established the interleukin-23 (IL-23)/interleukin-17 (IL-17) axis as a key mediator of psoriatic inflammation. IL-23, primarily derived from activated dendritic cells, suppo...