Structure-Activity Relationships and Ligand-Dependent Arrestin Bias in μ-Opioid Receptor-Mediated ERK Activation
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This study elucidated the structure-activity relationships (SAR) of three distinct opioid ligand series at the µ-opioid receptor (µ-OR) and investigated the ligand-dependent role of arrestin in downstream signaling. Radioligand binding assays across 13 compo... ...